SNF7_CRYNJ
ID SNF7_CRYNJ Reviewed; 220 AA.
AC P0CR54; Q55V53; Q5KL29;
DT 28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 25-MAY-2022, entry version 45.
DE RecName: Full=Vacuolar-sorting protein SNF7;
DE AltName: Full=Vacuolar protein-sorting-associated protein 32;
GN Name=SNF7; Synonyms=VPS32; OrderedLocusNames=CNC00960;
OS Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS MYA-565) (Filobasidiella neoformans).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=214684;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JEC21 / ATCC MYA-565;
RX PubMed=15653466; DOI=10.1126/science.1103773;
RA Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT neoformans.";
RL Science 307:1321-1324(2005).
CC -!- FUNCTION: Required for the sorting and concentration of proteins
CC resulting in the entry of these proteins into the invaginating vesicles
CC of the multivesicular body (MVB). Also required for the proteolytic
CC cleavage of the transcription factor RIM101 in response to alkaline
CC ambient pH (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: A component of the endosomal sorting required for transport
CC complex III (ESCRT-III). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Endosome membrane
CC {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SNF7 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE017343; AAW42105.1; -; Genomic_DNA.
DR RefSeq; XP_569412.1; XM_569412.1.
DR AlphaFoldDB; P0CR54; -.
DR SMR; P0CR54; -.
DR STRING; 5207.AAW42105; -.
DR PaxDb; P0CR54; -.
DR EnsemblFungi; AAW42105; AAW42105; CNC00960.
DR GeneID; 3256554; -.
DR KEGG; cne:CNC00960; -.
DR VEuPathDB; FungiDB:CNC00960; -.
DR eggNOG; KOG1656; Eukaryota.
DR HOGENOM; CLU_071097_1_1_1; -.
DR InParanoid; P0CR54; -.
DR OMA; WSWFGGA; -.
DR OrthoDB; 1490465at2759; -.
DR Proteomes; UP000002149; Chromosome 3.
DR GO; GO:0009898; C:cytoplasmic side of plasma membrane; IBA:GO_Central.
DR GO; GO:0000815; C:ESCRT III complex; IBA:GO_Central.
DR GO; GO:0005771; C:multivesicular body; IBA:GO_Central.
DR GO; GO:0042802; F:identical protein binding; IEA:EnsemblFungi.
DR GO; GO:1904669; P:ATP export; IEA:EnsemblFungi.
DR GO; GO:0071454; P:cellular response to anoxia; IEA:EnsemblFungi.
DR GO; GO:1904902; P:ESCRT III complex assembly; IEA:EnsemblFungi.
DR GO; GO:0070676; P:intralumenal vesicle formation; IEA:EnsemblFungi.
DR GO; GO:0032511; P:late endosome to vacuole transport via multivesicular body sorting pathway; IBA:GO_Central.
DR GO; GO:0043328; P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; IEA:EnsemblFungi.
DR GO; GO:0061709; P:reticulophagy; IEA:EnsemblFungi.
DR GO; GO:0006900; P:vesicle budding from membrane; IBA:GO_Central.
DR InterPro; IPR005024; Snf7_fam.
DR PANTHER; PTHR22761; PTHR22761; 1.
DR Pfam; PF03357; Snf7; 1.
PE 3: Inferred from homology;
KW Coiled coil; Cytoplasm; Endosome; Membrane; Reference proteome.
FT CHAIN 1..220
FT /note="Vacuolar-sorting protein SNF7"
FT /id="PRO_0000211439"
FT REGION 175..210
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 15..86
FT /evidence="ECO:0000255"
FT COILED 153..220
FT /evidence="ECO:0000255"
SQ SEQUENCE 220 AA; 24334 MW; FBDC6DF0091C31BE CRC64;
MSGWMSYFTG RKDTRESARD AIVGLRQQLL MLEKKEEFLQ KKIEEEMKKA KANATGNKRL
AMAALRQKKA HENELDRIAG TRLTLETQVN AIESANLNAE TMVAMKKGAD ALKGIHSNLT
AEGVDATMDK IREQMDLTND ISDAISNPVG MGIVLDEDDL KEELEALEQE QLDDRLAGAD
RVPSHLPASP VGQTTGRAAV EEDEDDEEAQ LRKLQAELAM
