ID   SNF7_DEBHA              Reviewed;         226 AA.
AC   Q6BSH2;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 2.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Vacuolar-sorting protein SNF7;
DE   AltName: Full=Vacuolar protein-sorting-associated protein 32;
GN   Name=SNF7; Synonyms=VPS32; OrderedLocusNames=DEHA2D08844g;
OS   Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS   / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX   NCBI_TaxID=284592;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Required for the sorting and concentration of proteins
CC       resulting in the entry of these proteins into the invaginating vesicles
CC       of the multivesicular body (MVB). Also required for the proteolytic
CC       cleavage of the transcription factor RIM101 in response to alkaline
CC       ambient pH (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: A component of the endosomal sorting required for transport
CC       complex III (ESCRT-III). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Endosome membrane
CC       {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SNF7 family. {ECO:0000305}.
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DR   EMBL; CR382136; CAG86999.2; -; Genomic_DNA.
DR   RefSeq; XP_458848.2; XM_458848.1.
DR   AlphaFoldDB; Q6BSH2; -.
DR   SMR; Q6BSH2; -.
DR   STRING; 4959.XP_458848.2; -.
DR   EnsemblFungi; CAG86999; CAG86999; DEHA2D08844g.
DR   GeneID; 2901254; -.
DR   KEGG; dha:DEHA2D08844g; -.
DR   VEuPathDB; FungiDB:DEHA2D08844g; -.
DR   eggNOG; KOG1656; Eukaryota.
DR   HOGENOM; CLU_071097_1_0_1; -.
DR   InParanoid; Q6BSH2; -.
DR   OMA; WSWFGGA; -.
DR   OrthoDB; 1490465at2759; -.
DR   Proteomes; UP000000599; Chromosome D.
DR   GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0045324; P:late endosome to vacuole transport; IEA:UniProt.
DR   InterPro; IPR005024; Snf7_fam.
DR   PANTHER; PTHR22761; PTHR22761; 1.
DR   Pfam; PF03357; Snf7; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Cytoplasm; Endosome; Membrane; Reference proteome.
FT   CHAIN           1..226
FT                   /note="Vacuolar-sorting protein SNF7"
FT                   /id="PRO_0000211440"
FT   REGION          164..226
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          18..177
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   226 AA;  25675 MW;  432CDF2047ABDCB1 CRC64;
     MWNYLFGGNK QQKKEYPKKA IVELREHIQM LNKKRSHLES QIADQDALAR KYITTNKALA
     KNALKRKKGY EANLMKIENQ IDSLETQLTS IEGANLNLET MKAMKQGAQA MKQIHGEYDV
     DKVENTMDDI REQVELADEI SEAISRPVGT EFVDEDELDE ELAMLQEEEK EHKQQTPAQK
     APVAKVSAPE EEMPDFPTVN KNKPAASTED DEDEEALKAL QAEMGL