ID   SNF7_KLULA              Reviewed;         232 AA.
AC   Q6CJL0;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=Vacuolar-sorting protein SNF7;
DE   AltName: Full=Vacuolar protein-sorting-associated protein 32;
GN   Name=SNF7; Synonyms=VPS32; OrderedLocusNames=KLLA0F17820g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Required for the sorting and concentration of proteins
CC       resulting in the entry of these proteins into the invaginating vesicles
CC       of the multivesicular body (MVB). Also required for the proteolytic
CC       cleavage of the transcription factor RIM101 in response to alkaline
CC       ambient pH (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: A component of the endosomal sorting required for transport
CC       complex III (ESCRT-III). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Endosome membrane
CC       {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SNF7 family. {ECO:0000305}.
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DR   EMBL; CR382126; CAG98587.1; -; Genomic_DNA.
DR   RefSeq; XP_455879.1; XM_455879.1.
DR   AlphaFoldDB; Q6CJL0; -.
DR   SMR; Q6CJL0; -.
DR   STRING; 28985.XP_455879.1; -.
DR   EnsemblFungi; CAG98587; CAG98587; KLLA0_F17820g.
DR   GeneID; 2895598; -.
DR   KEGG; kla:KLLA0_F17820g; -.
DR   eggNOG; KOG1656; Eukaryota.
DR   HOGENOM; CLU_071097_1_0_1; -.
DR   InParanoid; Q6CJL0; -.
DR   OMA; WSWFGGA; -.
DR   Proteomes; UP000000598; Chromosome F.
DR   GO; GO:0000815; C:ESCRT III complex; IEA:EnsemblFungi.
DR   GO; GO:0005886; C:plasma membrane; IEA:EnsemblFungi.
DR   GO; GO:0042802; F:identical protein binding; IEA:EnsemblFungi.
DR   GO; GO:1904669; P:ATP export; IEA:EnsemblFungi.
DR   GO; GO:0071454; P:cellular response to anoxia; IEA:EnsemblFungi.
DR   GO; GO:1904902; P:ESCRT III complex assembly; IEA:EnsemblFungi.
DR   GO; GO:0070676; P:intralumenal vesicle formation; IEA:EnsemblFungi.
DR   GO; GO:0043328; P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; IEA:EnsemblFungi.
DR   GO; GO:0061709; P:reticulophagy; IEA:EnsemblFungi.
DR   InterPro; IPR005024; Snf7_fam.
DR   PANTHER; PTHR22761; PTHR22761; 1.
DR   Pfam; PF03357; Snf7; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Endosome; Membrane; Reference proteome.
FT   CHAIN           1..232
FT                   /note="Vacuolar-sorting protein SNF7"
FT                   /id="PRO_0000211441"
FT   REGION          178..232
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        207..222
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   232 AA;  26644 MW;  4CB458E5D010E429 CRC64;
     MWGYFFGTSK QQKELPKKAI VDLREHIQLL NKKQAHLQTQ IDQQQQLAKK SLQSGNKNNA
     KTYLKKKKLY ESQLDKLQSQ IDSLDQQLYS IENANLNLET LKAMKQGASA MKNIHKGLDL
     DKVDDTMDEI REQVELNQEI SEAISKPLIL QDELDEDELD QELELLESEN LQKEHIAPVP
     QQQIQQPSID LPSVPDVKLS TPELNSAQAD EEDEEEDEDE RALRELQAEM GL