ID   SNF7_NEUCR              Reviewed;         228 AA.
AC   Q871Y8; Q1K6T8;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   25-MAY-2022, entry version 94.
DE   RecName: Full=Vacuolar-sorting protein snf7;
DE   AltName: Full=Vacuolar protein-sorting-associated protein 32;
GN   Name=vsp-3; Synonyms=snf7, vps32; ORFNames=B9K17.010, NCU01282;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12655011; DOI=10.1093/nar/gkg293;
RA   Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D.,
RA   Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.;
RT   "What's in the genome of a filamentous fungus? Analysis of the Neurospora
RT   genome sequence.";
RL   Nucleic Acids Res. 31:1944-1954(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- FUNCTION: Required for the sorting and concentration of proteins
CC       resulting in the entry of these proteins into the invaginating vesicles
CC       of the multivesicular body (MVB). Also required for the proteolytic
CC       cleavage of the transcription factor pacc-1 in response to alkaline
CC       ambient pH (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: A component of the endosomal sorting required for transport
CC       complex III (ESCRT-III). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Endosome membrane
CC       {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SNF7 family. {ECO:0000305}.
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DR   EMBL; BX294016; CAD70846.1; -; Genomic_DNA.
DR   EMBL; CM002240; EAA31583.1; -; Genomic_DNA.
DR   RefSeq; XP_960819.1; XM_955726.2.
DR   AlphaFoldDB; Q871Y8; -.
DR   SMR; Q871Y8; -.
DR   STRING; 5141.EFNCRP00000004016; -.
DR   EnsemblFungi; EAA31583; EAA31583; NCU01282.
DR   GeneID; 3876971; -.
DR   KEGG; ncr:NCU01282; -.
DR   VEuPathDB; FungiDB:NCU01282; -.
DR   HOGENOM; CLU_071097_1_0_1; -.
DR   InParanoid; Q871Y8; -.
DR   OMA; WSWFGGA; -.
DR   Proteomes; UP000001805; Chromosome 2, Linkage Group V.
DR   GO; GO:0009898; C:cytoplasmic side of plasma membrane; IBA:GO_Central.
DR   GO; GO:0000815; C:ESCRT III complex; IBA:GO_Central.
DR   GO; GO:0005771; C:multivesicular body; IBA:GO_Central.
DR   GO; GO:0042802; F:identical protein binding; IEA:EnsemblFungi.
DR   GO; GO:1904669; P:ATP export; IEA:EnsemblFungi.
DR   GO; GO:0071454; P:cellular response to anoxia; IEA:EnsemblFungi.
DR   GO; GO:1904902; P:ESCRT III complex assembly; IEA:EnsemblFungi.
DR   GO; GO:0070676; P:intralumenal vesicle formation; IEA:EnsemblFungi.
DR   GO; GO:0032511; P:late endosome to vacuole transport via multivesicular body sorting pathway; IBA:GO_Central.
DR   GO; GO:0043328; P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; IEA:EnsemblFungi.
DR   GO; GO:0061709; P:reticulophagy; IEA:EnsemblFungi.
DR   GO; GO:0006900; P:vesicle budding from membrane; IBA:GO_Central.
DR   InterPro; IPR005024; Snf7_fam.
DR   PANTHER; PTHR22761; PTHR22761; 1.
DR   Pfam; PF03357; Snf7; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Cytoplasm; Endosome; Membrane; Reference proteome.
FT   CHAIN           1..228
FT                   /note="Vacuolar-sorting protein snf7"
FT                   /id="PRO_0000211443"
FT   COILED          25..94
FT                   /evidence="ECO:0000255"
FT   COILED          125..226
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   228 AA;  24975 MW;  977A9FFDCA221A32 CRC64;
     MSGIWGWFGG GSAAQKRKDS PKNAILGLRT QLDMLQKRER HLQNQIDEQD AIARKNVSTN
     KTAAKQALRR KKVAESTLET TLGQITTLEQ QINAIESANI NRETLAAMQA AREAMGKIHG
     KLTPEKVDEE MAKLQEANDL SNEIATAITS ANIGQPIDEG ELEDELEKLQ QEEVDSKLHE
     TGGSIPVHDK ISLPAAGTGA LKGKEKAKAV VEDDEEEELR KLQAEMAM