ID   SNF7_YARLI              Reviewed;         215 AA.
AC   Q6CBS3;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 90.
DE   RecName: Full=Vacuolar-sorting protein SNF7;
DE   AltName: Full=Vacuolar protein-sorting-associated protein 32;
GN   Name=SNF7; Synonyms=VPS32; OrderedLocusNames=YALI0C16027g;
OS   Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 122 / E 150;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Required for the sorting and concentration of proteins
CC       resulting in the entry of these proteins into the invaginating vesicles
CC       of the multivesicular body (MVB). Also required for the proteolytic
CC       cleavage of the transcription factor RIM101 in response to alkaline
CC       ambient pH (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: A component of the endosomal sorting required for transport
CC       complex III (ESCRT-III). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Endosome membrane
CC       {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SNF7 family. {ECO:0000305}.
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DR   EMBL; CR382129; CAG82202.1; -; Genomic_DNA.
DR   RefSeq; XP_501889.1; XM_501889.1.
DR   AlphaFoldDB; Q6CBS3; -.
DR   SMR; Q6CBS3; -.
DR   STRING; 4952.CAG82202; -.
DR   EnsemblFungi; CAG82202; CAG82202; YALI0_C16027g.
DR   GeneID; 2909244; -.
DR   KEGG; yli:YALI0C16027g; -.
DR   VEuPathDB; FungiDB:YALI0_C16027g; -.
DR   HOGENOM; CLU_071097_1_0_1; -.
DR   InParanoid; Q6CBS3; -.
DR   OMA; WSWFGGA; -.
DR   Proteomes; UP000001300; Chromosome C.
DR   GO; GO:0009898; C:cytoplasmic side of plasma membrane; IBA:GO_Central.
DR   GO; GO:0000815; C:ESCRT III complex; IBA:GO_Central.
DR   GO; GO:0005771; C:multivesicular body; IBA:GO_Central.
DR   GO; GO:0042802; F:identical protein binding; IEA:EnsemblFungi.
DR   GO; GO:1904669; P:ATP export; IEA:EnsemblFungi.
DR   GO; GO:0071454; P:cellular response to anoxia; IEA:EnsemblFungi.
DR   GO; GO:1904902; P:ESCRT III complex assembly; IEA:EnsemblFungi.
DR   GO; GO:0070676; P:intralumenal vesicle formation; IEA:EnsemblFungi.
DR   GO; GO:0032511; P:late endosome to vacuole transport via multivesicular body sorting pathway; IBA:GO_Central.
DR   GO; GO:0043328; P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; IEA:EnsemblFungi.
DR   GO; GO:0061709; P:reticulophagy; IEA:EnsemblFungi.
DR   GO; GO:0006900; P:vesicle budding from membrane; IBA:GO_Central.
DR   InterPro; IPR005024; Snf7_fam.
DR   PANTHER; PTHR22761; PTHR22761; 1.
DR   Pfam; PF03357; Snf7; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Cytoplasm; Endosome; Membrane; Reference proteome.
FT   CHAIN           1..215
FT                   /note="Vacuolar-sorting protein SNF7"
FT                   /id="PRO_0000211445"
FT   REGION          182..215
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          14..85
FT                   /evidence="ECO:0000255"
FT   COILED          149..173
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   215 AA;  24334 MW;  9060989EC01AD834 CRC64;
     MWGFFGGAKK QDPKDTIISL RQQIIVLNKK NDNLIVQIQE QENLARKHVT TNKLMAKNAL
     KKKKNLEKQQ ETVQGSIDSL QTSINTLETA NLNLETMKAM QEGAKAMKQI HGNMNIDKVD
     KIMDETRDQV ALSEEVSEAI SRPYANAYDD EELEDELEAL EQETLEGELT NAGHVKQDGV
     QVTPHDLPAA PNQVPAEEED DEEEELRRLQ REMAL