ID   SNF8_XENTR              Reviewed;         257 AA.
AC   Q5RJU0;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Vacuolar-sorting protein SNF8;
DE   AltName: Full=ESCRT-II complex subunit VPS22;
GN   Name=snf8;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the endosomal sorting complex required for
CC       transport II (ESCRT-II), which is required for multivesicular body
CC       (MVB) formation and sorting of endosomal cargo proteins into MVBs. The
CC       MVB pathway mediates delivery of transmembrane proteins into the lumen
CC       of the lysosome for degradation. The ESCRT-II complex is probably
CC       involved in the recruitment of the ESCRT-III complex (By similarity).
CC       {ECO:0000250|UniProtKB:Q96H20}.
CC   -!- SUBUNIT: Component of the endosomal sorting complex required for
CC       transport II (ESCRT-II), composed of snf8, vps36 and vps25.
CC       {ECO:0000250|UniProtKB:Q96H20}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SNF8 family. {ECO:0000305}.
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DR   EMBL; BC086504; AAH86504.1; -; mRNA.
DR   RefSeq; NP_001011185.1; NM_001011185.2.
DR   AlphaFoldDB; Q5RJU0; -.
DR   SMR; Q5RJU0; -.
DR   DNASU; 496607; -.
DR   Ensembl; ENSXETT00000093747; ENSXETP00000078729; ENSXETG00000022819.
DR   GeneID; 496607; -.
DR   KEGG; xtr:496607; -.
DR   CTD; 11267; -.
DR   Xenbase; XB-GENE-961618; snf8.
DR   InParanoid; Q5RJU0; -.
DR   OrthoDB; 869548at2759; -.
DR   Proteomes; UP000008143; Chromosome 10.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000022819; Expressed in egg cell and 13 other tissues.
DR   GO; GO:0000814; C:ESCRT II complex; IBA:GO_Central.
DR   GO; GO:0043328; P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; IBA:GO_Central.
DR   Gene3D; 1.10.10.10; -; 2.
DR   InterPro; IPR016689; ESCRT-2_cplx_Snf8.
DR   InterPro; IPR040608; Snf8/Vps36.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR12806; PTHR12806; 1.
DR   Pfam; PF04157; EAP30; 1.
DR   PIRSF; PIRSF017215; ESCRT2_Vps22; 1.
DR   SUPFAM; SSF46785; SSF46785; 2.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Protein transport; Reference proteome; Transport.
FT   CHAIN           1..257
FT                   /note="Vacuolar-sorting protein SNF8"
FT                   /id="PRO_0000215213"
FT   COILED          28..50
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   257 AA;  28607 MW;  58B3EA48BAB61919 CRC64;
     MHRRGVGAGA IAKKKLAEAK YKERGTVLAE DQLLQMSKQL EMFKTNLEEF ASKHKQEIRK
     NPQFRVQFQD MCATIGVDPL ASGKGFWSEM LGVGDFYYEL GVQIIEVCLA LKHHNGGLIT
     LAELHQHVLK GRGKLAQDVS QDDIIRAIKK LKVLGNGFGI IPVGGSYLVQ SVPAELNMDH
     TVVLQLAEKK GFVTVNEIKS SLNWETERAK HVLEHLLKEG LAWIDSQAQG EAQYWLPALF
     TALYAQQINM DENGGPS