ID   SNG1_CAEEL              Reviewed;         247 AA.
AC   O76735; Q22340;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   03-AUG-2022, entry version 119.
DE   RecName: Full=Synaptogyrin homolog 1;
GN   Name=sng-1; ORFNames=T08A9.3;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   STRAIN=Bristol N2;
RX   PubMed=10476681; DOI=10.1016/s0165-0270(99)00031-x;
RA   Nonet M.L.;
RT   "Visualization of synaptic specializations in live C. elegans with synaptic
RT   vesicle protein-GFP fusions.";
RL   J. Neurosci. Methods 89:33-40(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- TISSUE SPECIFICITY: Expressed in a wide variety of neurons and is
CC       expressed weakly in the non-neuronal distal tip cells. A punctate
CC       pattern was observed in the ventral and dorsal nerve cords and the
CC       nerve ring. Weak expression is seen in neuronal cell bodies and
CC       commissures. {ECO:0000269|PubMed:10476681}.
CC   -!- SIMILARITY: Belongs to the synaptogyrin family. {ECO:0000305}.
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DR   EMBL; AF079373; AAC27798.1; -; mRNA.
DR   EMBL; FO080414; CCD63516.1; -; Genomic_DNA.
DR   PIR; F89567; F89567.
DR   PIR; T43324; T43324.
DR   RefSeq; NP_509239.1; NM_076838.4.
DR   AlphaFoldDB; O76735; -.
DR   STRING; 6239.T08A9.3; -.
DR   EPD; O76735; -.
DR   PaxDb; O76735; -.
DR   PeptideAtlas; O76735; -.
DR   EnsemblMetazoa; T08A9.3.1; T08A9.3.1; WBGene00004912.
DR   GeneID; 180995; -.
DR   KEGG; cel:CELE_T08A9.3; -.
DR   UCSC; T08A9.3; c. elegans.
DR   CTD; 180995; -.
DR   WormBase; T08A9.3; CE21167; WBGene00004912; sng-1.
DR   eggNOG; KOG4016; Eukaryota.
DR   GeneTree; ENSGT00950000182935; -.
DR   HOGENOM; CLU_1001978_0_0_1; -.
DR   InParanoid; O76735; -.
DR   OMA; WSQWSSA; -.
DR   OrthoDB; 1385502at2759; -.
DR   PhylomeDB; O76735; -.
DR   Reactome; R-CEL-6798695; Neutrophil degranulation.
DR   PRO; PR:O76735; -.
DR   Proteomes; UP000001940; Chromosome X.
DR   Bgee; WBGene00004912; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR   GO; GO:0031410; C:cytoplasmic vesicle; IDA:WormBase.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031594; C:neuromuscular junction; IBA:GO_Central.
DR   GO; GO:0008021; C:synaptic vesicle; IDA:WormBase.
DR   GO; GO:0030672; C:synaptic vesicle membrane; IBA:GO_Central.
DR   GO; GO:0017157; P:regulation of exocytosis; TAS:WormBase.
DR   GO; GO:0048489; P:synaptic vesicle transport; TAS:WormBase.
DR   InterPro; IPR008253; Marvel.
DR   InterPro; IPR016579; Synaptogyrin.
DR   PANTHER; PTHR10838; PTHR10838; 1.
DR   Pfam; PF01284; MARVEL; 1.
DR   PIRSF; PIRSF011282; Synaptogyrin; 1.
DR   PROSITE; PS51225; MARVEL; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..247
FT                   /note="Synaptogyrin homolog 1"
FT                   /id="PRO_0000184000"
FT   TRANSMEM        25..45
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        69..89
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        105..125
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        151..171
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          21..175
FT                   /note="MARVEL"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00581"
FT   REGION          206..247
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        217..247
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   247 AA;  26792 MW;  F199D0EEDEF1EEA0 CRC64;
     MENVRAYGAG LAGANFDKNT FFKKPTVLFR CAALLFGLIL WYSVSKGGWH KPSDAIHPVC
     LYGRSSSTCS FATAVGFFAV CGAIVLIVLD AKMDQISSVP TRRRAVLADL VVSAIFTAIF
     LIGFFTFWSK LSAFEVDEDD ENPIKTNNAK FGILSALLSF LAWGGAAFFA WRRYEEGNQA
     THEPNYDEHF GQVSTDVQDG YGYGGDSTGI GHVGAPPPQS SYQSGAAPQT MQQPPSNPYT
     QSEGYGY