ID   SNG2L_HUMAN             Reviewed;         223 AA.
AC   A8MWL6;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   04-DEC-2007, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Putative synaptogyrin-2 like protein;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16572171; DOI=10.1038/nature04601;
RA   Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA   Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA   FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA   Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA   Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA   DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J.,
RA   Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E.,
RA   Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B.,
RA   Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R.,
RA   O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B.,
RA   Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S.,
RA   Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.;
RT   "Analysis of the DNA sequence and duplication history of human chromosome
RT   15.";
RL   Nature 440:671-675(2006).
RN   [2]
RP   IDENTIFICATION.
RX   PubMed=9760194; DOI=10.1007/s004390050795;
RA   Kedra D., Pan H.-Q., Seroussi E., Fransson I., Guilbaud C., Collins J.E.,
RA   Dunham I., Blennow E., Roe B.A., Piehl F., Dumanski J.P.;
RT   "Characterization of the human synaptogyrin gene family.";
RL   Hum. Genet. 103:131-141(1998).
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the synaptogyrin family. {ECO:0000305}.
CC   -!- CAUTION: Could be the product of a pseudogene. According to
CC       PubMed:9760194, it is a processed pseudogene. {ECO:0000305}.
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DR   EMBL; AC111152; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; A8MWL6; -.
DR   iPTMnet; A8MWL6; -.
DR   PhosphoSitePlus; A8MWL6; -.
DR   BioMuta; -; -.
DR   jPOST; A8MWL6; -.
DR   MassIVE; A8MWL6; -.
DR   PeptideAtlas; A8MWL6; -.
DR   PRIDE; A8MWL6; -.
DR   neXtProt; NX_A8MWL6; -.
DR   PhylomeDB; A8MWL6; -.
DR   Pharos; A8MWL6; Tdark.
DR   Proteomes; UP000005640; Unplaced.
DR   RNAct; A8MWL6; protein.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031594; C:neuromuscular junction; IBA:GO_Central.
DR   GO; GO:0030672; C:synaptic vesicle membrane; IBA:GO_Central.
DR   InterPro; IPR008253; Marvel.
DR   InterPro; IPR016579; Synaptogyrin.
DR   PANTHER; PTHR10838; PTHR10838; 1.
DR   Pfam; PF01284; MARVEL; 1.
DR   PIRSF; PIRSF011282; Synaptogyrin; 1.
DR   PROSITE; PS51225; MARVEL; 1.
PE   5: Uncertain;
KW   Acetylation; Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..223
FT                   /note="Putative synaptogyrin-2 like protein"
FT                   /id="PRO_0000343945"
FT   TRANSMEM        26..46
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        71..91
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        104..124
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        146..166
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          20..170
FT                   /note="MARVEL"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00581"
FT   REGION          197..223
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        197..216
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         1
FT                   /note="N-acetylmethionine"
FT                   /evidence="ECO:0000250|UniProtKB:O43760"
FT   MOD_RES         3
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:O43760"
SQ   SEQUENCE   223 AA;  24647 MW;  760B5285325DC5EA CRC64;
     MESGAYGVAE AGGSFDLRPF LTQPQVVARA LCLVFALIVF SCIYGEGYSN THKSKQMYCV
     FNHNEDACRY GSAIGVLAFL ASAFLVVDAY FPQISNATDR KYLVIGDLLF SALWTFLWFV
     GFCFLTNQWA VTDPEDVLVG ADSARAAITF SFFSIFSWGV LASLTYQRYK AGVDDFIQNY
     VDPSPDPNTA YASYPGASVD NYQQPPFTQN AETTEGYQPP PVY