ID   SNG3_BOVIN              Reviewed;         229 AA.
AC   A2VE58;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-MAR-2007, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Synaptogyrin-3 {ECO:0000305};
GN   Name=SYNGR3 {ECO:0000250|UniProtKB:O43761};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal pons;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play a role in regulated exocytosis. May indirectly
CC       regulate the activity of the plasma membrane dopamine transporter
CC       SLC6A3 and thereby regulate dopamine transport back from the synaptic
CC       cleft into the presynaptic terminal. {ECO:0000250|UniProtKB:Q8R191}.
CC   -!- SUBUNIT: Interacts (via N-terminus) with SLC6A3 (via N-terminus). May
CC       interact with VMAT2. {ECO:0000250|UniProtKB:Q8R191}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic
CC       vesicle membrane {ECO:0000250|UniProtKB:Q8R191}; Multi-pass membrane
CC       protein {ECO:0000255}. Synapse {ECO:0000250|UniProtKB:Q8R191}.
CC       Note=Found at the neuromuscular synapses.
CC       {ECO:0000250|UniProtKB:Q8R191}.
CC   -!- SIMILARITY: Belongs to the synaptogyrin family. {ECO:0000305}.
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DR   EMBL; BC133586; AAI33587.1; -; mRNA.
DR   RefSeq; NP_001075933.1; NM_001082464.1.
DR   AlphaFoldDB; A2VE58; -.
DR   STRING; 9913.ENSBTAP00000011211; -.
DR   PaxDb; A2VE58; -.
DR   Ensembl; ENSBTAT00000011211; ENSBTAP00000011211; ENSBTAG00000008504.
DR   GeneID; 618415; -.
DR   KEGG; bta:618415; -.
DR   CTD; 9143; -.
DR   VEuPathDB; HostDB:ENSBTAG00000008504; -.
DR   VGNC; VGNC:35525; SYNGR3.
DR   eggNOG; KOG4016; Eukaryota.
DR   GeneTree; ENSGT00950000182935; -.
DR   HOGENOM; CLU_079186_0_1_1; -.
DR   InParanoid; A2VE58; -.
DR   OMA; ACRFGVV; -.
DR   OrthoDB; 1549362at2759; -.
DR   TreeFam; TF320995; -.
DR   Proteomes; UP000009136; Chromosome 25.
DR   Bgee; ENSBTAG00000008504; Expressed in Ammon's horn and 86 other tissues.
DR   ExpressionAtlas; A2VE58; baseline.
DR   GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031594; C:neuromuscular junction; IBA:GO_Central.
DR   GO; GO:0008021; C:synaptic vesicle; ISS:UniProtKB.
DR   GO; GO:0030672; C:synaptic vesicle membrane; IBA:GO_Central.
DR   GO; GO:0047485; F:protein N-terminus binding; IEA:Ensembl.
DR   GO; GO:0042169; F:SH2 domain binding; IEA:Ensembl.
DR   GO; GO:0032411; P:positive regulation of transporter activity; ISS:UniProtKB.
DR   GO; GO:0045055; P:regulated exocytosis; ISS:UniProtKB.
DR   InterPro; IPR008253; Marvel.
DR   InterPro; IPR016579; Synaptogyrin.
DR   PANTHER; PTHR10838; PTHR10838; 1.
DR   Pfam; PF01284; MARVEL; 1.
DR   PIRSF; PIRSF011282; Synaptogyrin; 1.
DR   PROSITE; PS51225; MARVEL; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Cytoplasmic vesicle; Membrane; Reference proteome; Synapse;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..229
FT                   /note="Synaptogyrin-3"
FT                   /id="PRO_0000343948"
FT   TRANSMEM        30..50
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        70..90
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        105..125
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        148..168
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          20..172
FT                   /note="MARVEL"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00581"
FT   MOD_RES         1
FT                   /note="N-acetylmethionine"
FT                   /evidence="ECO:0000250|UniProtKB:O43761"
SQ   SEQUENCE   229 AA;  24499 MW;  3642ACC34A7D4F6D CRC64;
     MEGGSFGAGR AGAALDPVSF ARRPQTLLRV ASWVFSIAVF GPIVNEGYVN ADSGPELRCV
     FNGNAGACRF GVALGLGAFL ACSCFLLLDV RFQQISSVRD RRRAVLLDLG FSGLWSFLWF
     VGFCFLTNQW QRTAPGPGTA QAGDAARAVI TFSFFSILSW VALTVKALQR FRLGTDMSLF
     ATEQLGAGAG QTYPGYPVGS GVEGTDTYQS PPFTETLDTS PKGYQVPAY