ID   SNG4_HUMAN              Reviewed;         234 AA.
AC   O95473; Q3KP58;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   13-NOV-2007, sequence version 2.
DT   03-AUG-2022, entry version 132.
DE   RecName: Full=Synaptogyrin-4;
GN   Name=SYNGR4;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Kedra D., Dumanski J.P.;
RT   "Cloning of a novel member of synaptogyrin gene family.";
RL   Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the synaptogyrin family. {ECO:0000305}.
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DR   EMBL; AJ011733; CAA09754.1; -; mRNA.
DR   EMBL; CH471177; EAW52339.1; -; Genomic_DNA.
DR   EMBL; BC106891; AAI06892.1; -; mRNA.
DR   CCDS; CCDS12717.1; -.
DR   RefSeq; NP_036583.2; NM_012451.3.
DR   RefSeq; XP_005258750.1; XM_005258693.2.
DR   RefSeq; XP_005258751.1; XM_005258694.2.
DR   AlphaFoldDB; O95473; -.
DR   BioGRID; 117090; 3.
DR   STRING; 9606.ENSP00000344041; -.
DR   iPTMnet; O95473; -.
DR   PhosphoSitePlus; O95473; -.
DR   BioMuta; SYNGR4; -.
DR   MassIVE; O95473; -.
DR   PaxDb; O95473; -.
DR   PeptideAtlas; O95473; -.
DR   PRIDE; O95473; -.
DR   ProteomicsDB; 50905; -.
DR   Antibodypedia; 31700; 144 antibodies from 31 providers.
DR   DNASU; 23546; -.
DR   Ensembl; ENST00000344846.7; ENSP00000344041.1; ENSG00000105467.9.
DR   GeneID; 23546; -.
DR   KEGG; hsa:23546; -.
DR   MANE-Select; ENST00000344846.7; ENSP00000344041.1; NM_012451.4; NP_036583.2.
DR   UCSC; uc002piz.4; human.
DR   CTD; 23546; -.
DR   GeneCards; SYNGR4; -.
DR   HGNC; HGNC:11502; SYNGR4.
DR   HPA; ENSG00000105467; Tissue enriched (testis).
DR   MIM; 608373; gene.
DR   neXtProt; NX_O95473; -.
DR   OpenTargets; ENSG00000105467; -.
DR   PharmGKB; PA36284; -.
DR   VEuPathDB; HostDB:ENSG00000105467; -.
DR   eggNOG; KOG4016; Eukaryota.
DR   GeneTree; ENSGT00950000182935; -.
DR   HOGENOM; CLU_1209470_0_0_1; -.
DR   InParanoid; O95473; -.
DR   OMA; SPQLHCV; -.
DR   OrthoDB; 1549362at2759; -.
DR   PhylomeDB; O95473; -.
DR   TreeFam; TF320995; -.
DR   PathwayCommons; O95473; -.
DR   BioGRID-ORCS; 23546; 13 hits in 1064 CRISPR screens.
DR   ChiTaRS; SYNGR4; human.
DR   GenomeRNAi; 23546; -.
DR   Pharos; O95473; Tdark.
DR   PRO; PR:O95473; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   RNAct; O95473; protein.
DR   Bgee; ENSG00000105467; Expressed in right testis and 89 other tissues.
DR   ExpressionAtlas; O95473; baseline and differential.
DR   Genevisible; O95473; HS.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031594; C:neuromuscular junction; IBA:GO_Central.
DR   GO; GO:0030672; C:synaptic vesicle membrane; IBA:GO_Central.
DR   InterPro; IPR008253; Marvel.
DR   InterPro; IPR016579; Synaptogyrin.
DR   PANTHER; PTHR10838; PTHR10838; 1.
DR   Pfam; PF01284; MARVEL; 1.
DR   PIRSF; PIRSF011282; Synaptogyrin; 1.
DR   PROSITE; PS51225; MARVEL; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..234
FT                   /note="Synaptogyrin-4"
FT                   /id="PRO_0000183998"
FT   TRANSMEM        25..45
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        66..86
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        104..124
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        145..165
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          18..169
FT                   /note="MARVEL"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00581"
FT   VARIANT         27
FT                   /note="R -> W (in dbSNP:rs919804)"
FT                   /id="VAR_052245"
FT   CONFLICT        38
FT                   /note="F -> I (in Ref. 1; CAA09754)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   234 AA;  25820 MW;  1CE517E82E2ABDE0 CRC64;
     MHIPKSLQEL ANSEAVQFLR RPKTITRVFE GVFSLIVFSS LLTDGYQNKM ESPQLHCILN
     SNSVACSFAV GAGFLAFLSC LAFLVLDTQE TRIAGTRFKT AFQLLDFILA VLWAVVWFMG
     FCFLANQWQH SPPKEFLLGS SSAQAAIAFT FFSILVWIFQ AYLAFQDLRN DAPVPYKRFL
     DEGGMVLTTL PLPSANSPVN MPTTGPNSLS YASSALSPCL TAPKSPRLAM MPDN