SNG_DROME
ID SNG_DROME Reviewed; 241 AA.
AC Q7JYV2;
DT 15-FEB-2017, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2006, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Synaptogyrin {ECO:0000303|PubMed:23238721};
GN Name=Syngr {ECO:0000312|FlyBase:FBgn0033876};
GN Synonyms=gyr {ECO:0000303|PubMed:23238721};
GN ORFNames=CG10808 {ECO:0000312|FlyBase:FBgn0033876};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227 {ECO:0000312|Proteomes:UP000000803};
RN [1] {ECO:0000312|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000312|Proteomes:UP000000803};
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2] {ECO:0000312|Proteomes:UP000000803}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley {ECO:0000312|Proteomes:UP000000803};
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3] {ECO:0000312|EMBL:AAL49375.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley {ECO:0000312|EMBL:AAL49375.1};
RC TISSUE=Head {ECO:0000312|EMBL:AAL49375.1};
RA Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J., Champe M.,
RA Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E., George R.,
RA Gonzalez M., Guarin H., Kronmiller B., Li P., Liao G., Miranda A.,
RA Mungall C.J., Nunoo J., Pacleb J., Paragas V., Park S., Patel S.,
RA Phouanenavong S., Wan K., Yu C., Lewis S.E., Rubin G.M., Celniker S.;
RL Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000305}
RP FUNCTION, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE, AND DISRUPTION
RP PHENOTYPE.
RX PubMed=23238721; DOI=10.1523/jneurosci.2668-12.2012;
RA Stevens R.J., Akbergenova Y., Jorquera R.A., Littleton J.T.;
RT "Abnormal synaptic vesicle biogenesis in Drosophila synaptogyrin mutants.";
RL J. Neurosci. 32:18054-18067(2012).
CC -!- FUNCTION: Required for the correct formation of synaptic vesicles at
CC nerve terminals and has a role in the regulation of the synaptic
CC vesicle exo-endocytic cycle. {ECO:0000269|PubMed:23238721}.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane
CC {ECO:0000269|PubMed:23238721}; Multi-pass membrane protein
CC {ECO:0000255}. Cytoplasmic vesicle, secretory vesicle membrane
CC {ECO:0000269|PubMed:23238721}; Multi-pass membrane protein
CC {ECO:0000255}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle
CC membrane {ECO:0000269|PubMed:23238721}; Multi-pass membrane protein
CC {ECO:0000255}. Note=In larvae expressed in the synaptic neuropil of the
CC central nervous system. {ECO:0000269|PubMed:23238721}.
CC -!- DEVELOPMENTAL STAGE: Expressed throughout the larval brain, ventral
CC nerve cord (VNC) and neuromuscular junction (NMJ) (at protein level).
CC {ECO:0000269|PubMed:23238721}.
CC -!- DISRUPTION PHENOTYPE: No obvious phenotype. Viable and fertile with
CC normal basic motor functions. However in type 1b boutons at the larval
CC neuromuscular junction of some mutants (30-40%), there is an increase
CC in the number of synaptic vesicles with a large diameter and a decrease
CC in vesicle density under resting conditions. Resolution of synaptic
CC vesicles from endocytic cisternae following an intense stimulation is
CC delayed, and consequently boutons display an increased number of
CC cisternae. Mutant larvae also show an increase in the amplitude of
CC spontaneous miniature excitatory junctional currents (mEJCs), but
CC normal evoked excitatory junction currents (EJCs). No effect on
CC synaptic growth, the number of synaptic vesicle release sites and
CC vesicle budding. {ECO:0000269|PubMed:23238721}.
CC -!- SIMILARITY: Belongs to the synaptogyrin family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE013599; AAF58329.1; -; Genomic_DNA.
DR EMBL; AY071753; AAL49375.1; -; mRNA.
DR RefSeq; NP_610908.1; NM_137064.3.
DR AlphaFoldDB; Q7JYV2; -.
DR IntAct; Q7JYV2; 5.
DR STRING; 7227.FBpp0086771; -.
DR PaxDb; Q7JYV2; -.
DR PRIDE; Q7JYV2; -.
DR DNASU; 36533; -.
DR EnsemblMetazoa; FBtr0087645; FBpp0086771; FBgn0033876.
DR GeneID; 36533; -.
DR KEGG; dme:Dmel_CG10808; -.
DR UCSC; CG10808-RA; d. melanogaster.
DR CTD; 36533; -.
DR FlyBase; FBgn0033876; Syngr.
DR VEuPathDB; VectorBase:FBgn0033876; -.
DR eggNOG; KOG4016; Eukaryota.
DR GeneTree; ENSGT00950000182935; -.
DR HOGENOM; CLU_079186_0_0_1; -.
DR InParanoid; Q7JYV2; -.
DR OMA; WSQWSSA; -.
DR OrthoDB; 1549362at2759; -.
DR PhylomeDB; Q7JYV2; -.
DR Reactome; R-DME-6798695; Neutrophil degranulation.
DR BioGRID-ORCS; 36533; 0 hits in 3 CRISPR screens.
DR ChiTaRS; Syngr; fly.
DR GenomeRNAi; 36533; -.
DR PRO; PR:Q7JYV2; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0033876; Expressed in head capsule and 8 other tissues.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031594; C:neuromuscular junction; IBA:GO_Central.
DR GO; GO:0030672; C:synaptic vesicle membrane; IBA:GO_Central.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR GO; GO:0098693; P:regulation of synaptic vesicle cycle; IDA:SynGO.
DR GO; GO:0016079; P:synaptic vesicle exocytosis; ISS:FlyBase.
DR GO; GO:0048489; P:synaptic vesicle transport; IMP:FlyBase.
DR InterPro; IPR008253; Marvel.
DR InterPro; IPR016579; Synaptogyrin.
DR PANTHER; PTHR10838; PTHR10838; 1.
DR Pfam; PF01284; MARVEL; 1.
DR PIRSF; PIRSF011282; Synaptogyrin; 1.
DR PROSITE; PS51225; MARVEL; 1.
PE 1: Evidence at protein level;
KW Cytoplasmic vesicle; Endocytosis; Membrane; Reference proteome; Synapse;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..241
FT /note="Synaptogyrin"
FT /id="PRO_0000438875"
FT TRANSMEM 34..54
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 81..101
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 115..135
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 155..175
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 30..179
FT /note="MARVEL"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00581"
FT REGION 216..241
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 241 AA; 26610 MW; CFDBA1D44450E86A CRC64;
MDMLNQILSI NNGGAYGGGK AGGAFDPLTF AMKPQVVIRA LCWLFSVVVF GCISSEGWTE
KDGKEYCLYN GDGMACKYGN MVGVFGFLAS MGFMGGEFLF ERMSSVKSRK RYVMADMGFS
ALWTFMYFVA FLYLWSQWSS SAPPPLGIGA GSMKTAIWFC LFSIVSWALC ALMAYKRFLI
GAGDEFTSAF ETDPANVVHQ QAYGYSMDND NDQYSASPFG QPQQGGMEQQ QSGMEYQQPT
Y
