SNL4_ARATH
ID SNL4_ARATH Reviewed; 1326 AA.
AC O04539; F4I3W8;
DT 18-MAY-2010, integrated into UniProtKB/Swiss-Prot.
DT 25-JAN-2012, sequence version 3.
DT 25-MAY-2022, entry version 124.
DE RecName: Full=Paired amphipathic helix protein Sin3-like 4;
GN Name=SNL4; OrderedLocusNames=At1g70060; ORFNames=F20P5.21;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=19962994; DOI=10.1016/j.jmb.2009.11.065;
RA Bowen A.J., Gonzalez D., Mullins J.G., Bhatt A.M., Martinez A.,
RA Conlan R.S.;
RT "PAH-domain-specific interactions of the Arabidopsis transcription
RT coregulator SIN3-LIKE1 (SNL1) with telomere-binding protein 1 and ALWAYS
RT EARLY2 Myb-DNA binding factors.";
RL J. Mol. Biol. 395:937-949(2010).
CC -!- FUNCTION: Acts as a transcriptional repressor. Plays roles in
CC regulating gene expression and genome stability (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00810}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAB61107.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC002062; AAB61107.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE35012.1; -; Genomic_DNA.
DR EMBL; CP002684; ANM60804.1; -; Genomic_DNA.
DR PIR; C96723; C96723.
DR RefSeq; NP_001323064.1; NM_001334433.1.
DR RefSeq; NP_177163.3; NM_105674.6.
DR AlphaFoldDB; O04539; -.
DR SMR; O04539; -.
DR IntAct; O04539; 1.
DR STRING; 3702.AT1G70060.1; -.
DR iPTMnet; O04539; -.
DR PaxDb; O04539; -.
DR PRIDE; O04539; -.
DR ProteomicsDB; 232645; -.
DR EnsemblPlants; AT1G70060.1; AT1G70060.1; AT1G70060.
DR EnsemblPlants; AT1G70060.2; AT1G70060.2; AT1G70060.
DR GeneID; 843342; -.
DR Gramene; AT1G70060.1; AT1G70060.1; AT1G70060.
DR Gramene; AT1G70060.2; AT1G70060.2; AT1G70060.
DR KEGG; ath:AT1G70060; -.
DR Araport; AT1G70060; -.
DR TAIR; locus:2020563; AT1G70060.
DR eggNOG; KOG4204; Eukaryota.
DR HOGENOM; CLU_007140_1_0_1; -.
DR InParanoid; O04539; -.
DR OMA; HNAVKPL; -.
DR OrthoDB; 253485at2759; -.
DR PRO; PR:O04539; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; O04539; baseline and differential.
DR Genevisible; O04539; AT.
DR GO; GO:0000785; C:chromatin; IBA:GO_Central.
DR GO; GO:0000118; C:histone deacetylase complex; IBA:GO_Central.
DR GO; GO:0003714; F:transcription corepressor activity; IBA:GO_Central.
DR GO; GO:0016575; P:histone deacetylation; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 1.20.1160.11; -; 3.
DR InterPro; IPR013194; HDAC_interact_dom.
DR InterPro; IPR003822; PAH.
DR InterPro; IPR036600; PAH_sf.
DR InterPro; IPR039774; Sin3-like.
DR InterPro; IPR031693; Sin3_C.
DR PANTHER; PTHR12346; PTHR12346; 2.
DR Pfam; PF02671; PAH; 3.
DR Pfam; PF08295; Sin3_corepress; 1.
DR Pfam; PF16879; Sin3a_C; 1.
DR SMART; SM00761; HDAC_interact; 1.
DR SUPFAM; SSF47762; SSF47762; 3.
DR PROSITE; PS51477; PAH; 3.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; Repeat; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..1326
FT /note="Paired amphipathic helix protein Sin3-like 4"
FT /id="PRO_0000394042"
FT DOMAIN 8..78
FT /note="PAH 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00810"
FT DOMAIN 95..165
FT /note="PAH 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00810"
FT DOMAIN 292..367
FT /note="PAH 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00810"
FT REGION 272..299
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 715..812
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 844..864
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 927..1000
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 720..742
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 743..775
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 782..801
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 844..858
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 938..959
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 963..986
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1326 AA; 150792 MW; CA8075C42191D29F CRC64;
MVGGSSAQKL TTNDALAYLK AVKDKFQDKR DKYDEFLEVM KDFKAQRVDT TGVILRVKEL
FKGNRELILG FNTFLPKGFE ITLRPEDDQP AAPKKPVEFE EAISFVNKIK TRFQGDDRVY
KSFLDILNMY RKENKSITEV YHEVAILFRD HHDLLGEFTH FLPDTSATAS TNDSVKVPVR
DRGIKSLPTM RQIDLDKKDR IITSHPNRAL KTENMDVDHE RSLLKDSKEE VRRIDKKNDF
MDDRDRKDYR GLDHDSHKEH FFNSKKKLIR KDDDSAEMSD QAREGDKFSG AIPSSSTYDE
KGHSQELAFV DRVKAKLDTA DNQEFLRCLN LYSKEIISQP ELQSLVSDLI GVYPDLMDAF
KVFLAQCDKN DGLLSGIVSK KSLWSEGKCP QPTKSLDKDT DREREKIERY RERDREKERL
EKVAASQKWA KPISELDLSN CEQCTPSYRR LPKNYPIPIA SQKMEIGSQV LNDHWVSVTS
GSEDYSFKHM RKNQYEESLF KCEDDRFELD MLLESVISAT NRVEELLAKI NSNELKTDTP
ICIEDHLTAL NLRCIERLYS DHGLDVLDLL KKNAYLALPV ILTRLKQKQE EWARCRTEFN
KVWADIYTKN YHRSLDHRSF YFKQQDSKNL STKALLAEIK EISEKKRGED DALLALAAGN
RRTISSNMSF DYPDPDLHED LYQLIKYSCG EMCSTEQLDK VMKVWTEFLE PIFGVPSRPQ
GAEDREDAVK STNHDREDQE DAVSPQNGAS IANSMRSNGP RKVNESNQVR QASELDKDVT
SSKTSDALLS CDNTQNDKMP KNLTTPDERA ETKQAVSIER AHNSNALPLD GLLPQRNGKI
SSLSVAGLSN SNPKPALTSG TEELKPNYVN GPRVEIGDNP VIPNGTVAEW FAGEAKVERE
EGELSPTGDF EEDNYAVHGE NDMEALSKSK ENDATADDAS APRSSDGSGN TSHNGDVSGT
DSGDGEDCYR EDDIDHNKVE SEGEAEEGMS DGHDDTEGDM PVLSISVKNL LHVKPLAKYV
PPALYDKDND DSRKNSQVFY GNDSFYVLFR LHQILYDRIL SAKINSSSPD RKWKTSNPTN
PADSYARIMD ALYNLLDGTS DNSKFEDDCR AIIGTQSYVL FTLDKLIYKL IKHLQAVAAD
EMDNKLQQLY AYEKSRKPEK FLDAVYYENA LVLLPDEDIY RIECEQSTPS KLSIQLLDYG
HDKPDVTSIS MDPTFAAYLH NVFLSYQPNA KENPRIYLKR NKRKNGGDDE LCTTDEVKII
NGLECKITCS SSKVSYVLDT EDVLHRAKRR KLLNQSGLPL AHDSVCSGSL IRQRRTQRYQ
KLLTGQ
