SNL5_ARATH
ID SNL5_ARATH Reviewed; 1162 AA.
AC Q9XIE1; F4IEM9;
DT 18-MAY-2010, integrated into UniProtKB/Swiss-Prot.
DT 16-NOV-2011, sequence version 3.
DT 25-MAY-2022, entry version 114.
DE RecName: Full=Paired amphipathic helix protein Sin3-like 5;
GN Name=SNL5; OrderedLocusNames=At1g59890; ORFNames=F23H11.20;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=19962994; DOI=10.1016/j.jmb.2009.11.065;
RA Bowen A.J., Gonzalez D., Mullins J.G., Bhatt A.M., Martinez A.,
RA Conlan R.S.;
RT "PAH-domain-specific interactions of the Arabidopsis transcription
RT coregulator SIN3-LIKE1 (SNL1) with telomere-binding protein 1 and ALWAYS
RT EARLY2 Myb-DNA binding factors.";
RL J. Mol. Biol. 395:937-949(2010).
CC -!- FUNCTION: Acts as a transcriptional repressor. Plays roles in
CC regulating gene expression and genome stability (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00810}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=1;
CC Comment=A number of isoforms are produced. According to EST
CC sequences.;
CC Name=1;
CC IsoId=Q9XIE1-1; Sequence=Displayed;
CC -!- SEQUENCE CAUTION:
CC Sequence=AAD39330.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC007258; AAD39330.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE33634.1; -; Genomic_DNA.
DR PIR; A96623; A96623.
DR RefSeq; NP_176197.3; NM_104681.6. [Q9XIE1-1]
DR AlphaFoldDB; Q9XIE1; -.
DR SMR; Q9XIE1; -.
DR BioGRID; 27508; 1.
DR STRING; 3702.AT1G59890.2; -.
DR iPTMnet; Q9XIE1; -.
DR MetOSite; Q9XIE1; -.
DR PaxDb; Q9XIE1; -.
DR PRIDE; Q9XIE1; -.
DR ProteomicsDB; 228451; -. [Q9XIE1-1]
DR EnsemblPlants; AT1G59890.1; AT1G59890.1; AT1G59890. [Q9XIE1-1]
DR GeneID; 842283; -.
DR Gramene; AT1G59890.1; AT1G59890.1; AT1G59890. [Q9XIE1-1]
DR KEGG; ath:AT1G59890; -.
DR Araport; AT1G59890; -.
DR eggNOG; KOG4204; Eukaryota.
DR InParanoid; Q9XIE1; -.
DR OMA; QWPPGED; -.
DR PRO; PR:Q9XIE1; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9XIE1; baseline and differential.
DR Genevisible; Q9XIE1; AT.
DR GO; GO:0000785; C:chromatin; IBA:GO_Central.
DR GO; GO:0000118; C:histone deacetylase complex; IBA:GO_Central.
DR GO; GO:0003714; F:transcription corepressor activity; IBA:GO_Central.
DR GO; GO:0016575; P:histone deacetylation; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 1.20.1160.11; -; 2.
DR InterPro; IPR013194; HDAC_interact_dom.
DR InterPro; IPR003822; PAH.
DR InterPro; IPR036600; PAH_sf.
DR InterPro; IPR039774; Sin3-like.
DR InterPro; IPR031693; Sin3_C.
DR PANTHER; PTHR12346; PTHR12346; 1.
DR Pfam; PF02671; PAH; 2.
DR Pfam; PF08295; Sin3_corepress; 1.
DR Pfam; PF16879; Sin3a_C; 1.
DR SMART; SM00761; HDAC_interact; 1.
DR SUPFAM; SSF47762; SSF47762; 2.
DR PROSITE; PS51477; PAH; 2.
PE 3: Inferred from homology;
KW Alternative splicing; Nucleus; Phosphoprotein; Reference proteome; Repeat;
KW Repressor; Transcription; Transcription regulation.
FT CHAIN 1..1162
FT /note="Paired amphipathic helix protein Sin3-like 5"
FT /id="PRO_0000394043"
FT DOMAIN 28..109
FT /note="PAH 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00810"
FT DOMAIN 123..193
FT /note="PAH 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00810"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 702..727
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 743..779
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 803..830
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1121..1143
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 18..37
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 705..722
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 817
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9LFQ3"
SQ SEQUENCE 1162 AA; 132600 MW; EA533C61C8236C70 CRC64;
MKRVREEVYV EPQMRGPTVS SRGETNGRPS TISGGGTTGG LTTVDALTYL KAVKDMFQDN
KEKYETFLGV MKDFKAQRVD TNGVIARVKD LFKGYDDLLL GFNTFLPKGY KITLQPEDEK
PKKPVDFQVA IEFVNRIKAR FGGDDRAYKK FLDILNMYRK ETKSINEVYQ EVTLLFQDHE
DLLGEFVHFL PDFRGSVSVN DPLFQRNTIP RDRNSTFPGM HPKHFEKKIK RSRHDEYTEL
SDQREDGDEN LVAYSAESLA NQGQWPGYPK VEDTEGIQIY ESNGGHERDP DIGSQKNLLS
TNHMAKAINE LDLTDCAQCT PSYRRLPDDY PIQIPSYRNS LGEKVLNDHW VSVTSGSEDY
SFKHMRKNQY EESLFRCEDD RFELDMLLES VSAAIKRVES LLEKINNNTI SIETPICIRE
HLSELNLRCI ERLYGDYGLD VMDFLKKNSH IALPVILTRL KQKQEEWARC RADFRKVWAE
VYAKNHHKSL DHRSFYFKQQ DSKNLSTKGL VAEIKDISER KHKEDLLRAI AVGTKPSFTP
DVEFIYTDTK VHTDLYKLIK YYCEEICATE QSDKVMKLWV TFLEPMFGVP SRSETIETMK
DVAKIEDNQE HHDASEAVKE NTCDGSMASN LKPLTPPKMP NKENPMIQGS SFAQDLPVNT
GESIQQDKLH DVAAITNEDS QPSKLVSTRN DLIMEGVENR SRVSDVSMGG HKVEREEGEL
SPTESCEQEN FEVYKENGLE PVQKLPDNEI SNTDREPKEG ACGTEAVTRS NALPEDDDNK
ITQKLSEGDE NASKFIVSAS KFGGQVSSDE EHKGAESENE AGGMVNSNEG EDGSFFTFSE
RYLQPVKPLA KHVPGTLQAS ECDTRNDSRV FYGNDSLYVL FRLHQMLYER IQSAKIHSER
KWKAPDSTST DSYTRFMEAL YNLLDGSSDN TKFEDECRAI IGAQSYVLFT LDKLVQKFVK
HLHAVAADET DTKLLQLYAY ENYRKPGRFF DIVYHENARA LLHDQNIYRI EYSSAQTRLG
IQLMNSWNDQ PEVTAVTVEP GFANYLQNDF LSFVSDEEKP GLFLKRNKAK LSGPGEESLG
MSRALEGLNI INEVECKIAC SSFKVKYEPH TADLLYRRKQ KKATLNPTGP ENVKTSDSSE
LSRKKRISRF HMSLNRRLVA LP
