SNL6_ARATH
ID SNL6_ARATH Reviewed; 1173 AA.
AC Q9XIK6; F4I4C3;
DT 18-MAY-2010, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 2.
DT 25-MAY-2022, entry version 108.
DE RecName: Full=Paired amphipathic helix protein Sin3-like 6;
GN Name=SNL6; OrderedLocusNames=At1g10450; ORFNames=T10O24.5;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=19962994; DOI=10.1016/j.jmb.2009.11.065;
RA Bowen A.J., Gonzalez D., Mullins J.G., Bhatt A.M., Martinez A.,
RA Conlan R.S.;
RT "PAH-domain-specific interactions of the Arabidopsis transcription
RT coregulator SIN3-LIKE1 (SNL1) with telomere-binding protein 1 and ALWAYS
RT EARLY2 Myb-DNA binding factors.";
RL J. Mol. Biol. 395:937-949(2010).
CC -!- FUNCTION: Acts as a transcriptional repressor. Plays roles in
CC regulating gene expression and genome stability (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00810}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAD39565.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=AEE28580.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AC007067; AAD39565.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE28580.1; ALT_INIT; Genomic_DNA.
DR EMBL; CP002684; ANM59404.1; -; Genomic_DNA.
DR PIR; C86238; C86238.
DR RefSeq; NP_001321764.1; NM_001331906.1.
DR RefSeq; NP_001321765.1; NM_001331907.1.
DR RefSeq; NP_172515.2; NM_100919.5.
DR AlphaFoldDB; Q9XIK6; -.
DR SMR; Q9XIK6; -.
DR IntAct; Q9XIK6; 1.
DR STRING; 3702.AT1G10450.1; -.
DR iPTMnet; Q9XIK6; -.
DR PaxDb; Q9XIK6; -.
DR PRIDE; Q9XIK6; -.
DR ProteomicsDB; 234533; -.
DR EnsemblPlants; AT1G10450.3; AT1G10450.3; AT1G10450.
DR GeneID; 837584; -.
DR Gramene; AT1G10450.3; AT1G10450.3; AT1G10450.
DR KEGG; ath:AT1G10450; -.
DR Araport; AT1G10450; -.
DR eggNOG; KOG4204; Eukaryota.
DR HOGENOM; CLU_007140_1_0_1; -.
DR InParanoid; Q9XIK6; -.
DR OrthoDB; 253485at2759; -.
DR PhylomeDB; Q9XIK6; -.
DR PRO; PR:Q9XIK6; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9XIK6; baseline and differential.
DR Genevisible; Q9XIK6; AT.
DR GO; GO:0000785; C:chromatin; IBA:GO_Central.
DR GO; GO:0000118; C:histone deacetylase complex; IBA:GO_Central.
DR GO; GO:0003714; F:transcription corepressor activity; IBA:GO_Central.
DR GO; GO:0016575; P:histone deacetylation; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 1.20.1160.11; -; 2.
DR InterPro; IPR013194; HDAC_interact_dom.
DR InterPro; IPR003822; PAH.
DR InterPro; IPR036600; PAH_sf.
DR InterPro; IPR039774; Sin3-like.
DR InterPro; IPR031693; Sin3_C.
DR PANTHER; PTHR12346; PTHR12346; 1.
DR Pfam; PF02671; PAH; 2.
DR Pfam; PF08295; Sin3_corepress; 1.
DR Pfam; PF16879; Sin3a_C; 1.
DR SMART; SM00761; HDAC_interact; 1.
DR SUPFAM; SSF47762; SSF47762; 2.
DR PROSITE; PS51477; PAH; 2.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; Repeat; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..1173
FT /note="Paired amphipathic helix protein Sin3-like 6"
FT /id="PRO_0000394044"
FT DOMAIN 79..148
FT /note="PAH 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00810"
FT DOMAIN 162..232
FT /note="PAH 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00810"
FT REGION 40..75
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 236..337
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 655..697
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 740..813
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 46..74
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 251..283
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 300..317
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 318..337
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 671..689
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 750..774
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 775..810
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1173 AA; 134417 MW; 0F4DC113B65134BC CRC64;
MRDLLLGTTI PSYFSWLGLF PRFLVWFGFL KASFFCSSRN QSAGESGRRL KMKRAREDVH
TDTQKRKPEV SSRGETNKLP RTIDALTYLK AVKDIFHDNK EKYESFLELM KEFKAQTIDT
NGVIERIKVL FKGYRDLLLG FNTFLPKGYK ITLLPEEEKP KIRVDFKDAI GFVTKIKTRF
GDDEHAYKRF LDILNLYRKE KKSISEVYEE VTMLFKGHED LLMEFVNFLP NCPESAPSTK
NAVPRHKGTA TTAMHSDKKR KQRCKLEDYS GHSDQREDGD ENLVTCSADS PVGEGQPGYF
RDYENREDTE TDTADRTEKS AASGSQDIGN HKSTTKYVGT PINELDLSEC TQCTPSYRLL
PKDYAVEIPS YRNTLGKKTL NDHLVSVTSG SEDYSFSHMR KNQYEESLFR CEDDRYEMDM
LLGSVSSAIK QVEILLEKMN NNTISVDSTI CIEKHLSAMN LRCIERLYGD NGLDVMDLLK
KNMHSALPVI LTRLKQKQEE WARCHSDFQK VWAEVYAKNH HKSLDHRSFY FKQQDSKNLS
TKCLVAEVKD ISEKKHQEDL LQAIAVRVMP LFTPDLEFNY CDTQIHEDLY LLIKYYCEEI
CATEQSDKVM KLWITFLEPI FGILSRSQDN LALEDVSKLK NNRELQDACL AVKETASGSN
RKHPISPKRL SKDNTKMQGS SSREDVSANI KVKTAQPDKL QDDAAMTNEV IQSSKFVSPK
NDQIMEDEGN HMVNAASVEK HELEEGELSP TASREQSNFE VNGQNAFKPL QKVTDNVRSN
KDKQSCDKKG AKNKTRAEDD KQENCHKLSE NNKTASEMLV SGTKVSCHEE NNRVMNCNGR
GSVAGEMANG NQGEDGSFAF SERFLQTVKP VAKHLSWPLQ ASETCSQNDS QVFYGNDSYY
VLFRLHQMLY ERIQTAKKHS EKKWKAADNT TPDSYPRFMD ALYNLLDGSI DNTKFEDECR
AIFGAQSYVL FTLDKLVQKF VKHLHSVASD ETDTKLLQLH AYENYRKPGK FFDLVYHENA
CALLHEANIY RIRYSSEGTR LSIQLMNSGN NQLEVMGVAM EPAFADYLQN KCLKSVNDEE
NHGLFLNRNK KKFTSLDESR GMPVAMERLN IINEMECRMA CSSSKVKYVA NTSDLLYRSK
QGKPNSRVSE ILKQRRISRF HIMLNCRLCA LPL
