SNL6_ORYSJ
ID SNL6_ORYSJ Reviewed; 379 AA.
AC Q0JKZ0; Q5VNM1; Q5VNM2;
DT 07-SEP-2016, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2006, sequence version 1.
DT 03-AUG-2022, entry version 95.
DE RecName: Full=Cinnamoyl-CoA reductase-like SNL6 {ECO:0000305};
DE EC=1.2.-.- {ECO:0000305};
DE AltName: Full=Protein SUPPRESSOR OF NH1-MEDIATED LESION 6 {ECO:0000303|PubMed:20862311};
GN Name=SNL6 {ECO:0000303|PubMed:20862311};
GN OrderedLocusNames=Os01g0639200 {ECO:0000312|EMBL:BAF05588.1},
GN LOC_Os01g45200 {ECO:0000305};
GN ORFNames=P0004A09.22 {ECO:0000312|EMBL:BAD68587.1},
GN P0004A09.23 {ECO:0000312|EMBL:BAD68588.1},
GN P0696E01.43 {ECO:0000312|EMBL:BAD68953.1},
GN P0696E01.44 {ECO:0000312|EMBL:BAD68954.1};
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=12447438; DOI=10.1038/nature01184;
RA Sasaki T., Matsumoto T., Yamamoto K., Sakata K., Baba T., Katayose Y.,
RA Wu J., Niimura Y., Cheng Z., Nagamura Y., Antonio B.A., Kanamori H.,
RA Hosokawa S., Masukawa M., Arikawa K., Chiden Y., Hayashi M., Okamoto M.,
RA Ando T., Aoki H., Arita K., Hamada M., Harada C., Hijishita S., Honda M.,
RA Ichikawa Y., Idonuma A., Iijima M., Ikeda M., Ikeno M., Ito S., Ito T.,
RA Ito Y., Ito Y., Iwabuchi A., Kamiya K., Karasawa W., Katagiri S.,
RA Kikuta A., Kobayashi N., Kono I., Machita K., Maehara T., Mizuno H.,
RA Mizubayashi T., Mukai Y., Nagasaki H., Nakashima M., Nakama Y.,
RA Nakamichi Y., Nakamura M., Namiki N., Negishi M., Ohta I., Ono N., Saji S.,
RA Sakai K., Shibata M., Shimokawa T., Shomura A., Song J., Takazaki Y.,
RA Terasawa K., Tsuji K., Waki K., Yamagata H., Yamane H., Yoshiki S.,
RA Yoshihara R., Yukawa K., Zhong H., Iwama H., Endo T., Ito H., Hahn J.H.,
RA Kim H.-I., Eun M.-Y., Yano M., Jiang J., Gojobori T.;
RT "The genome sequence and structure of rice chromosome 1.";
RL Nature 420:312-316(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=18089549; DOI=10.1093/nar/gkm978;
RG The rice annotation project (RAP);
RT "The rice annotation project database (RAP-DB): 2008 update.";
RL Nucleic Acids Res. 36:D1028-D1033(2008).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [5]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=20862311; DOI=10.1371/journal.pgen.1001123;
RA Bart R.S., Chern M., Vega-Sanchez M.E., Canlas P., Ronald P.C.;
RT "Rice Snl6, a cinnamoyl-CoA reductase-like gene family member, is required
RT for NH1-mediated immunity to Xanthomonas oryzae pv. oryzae.";
RL PLoS Genet. 6:E1001123-E1001123(2010).
CC -!- FUNCTION: Involved in defense response. Required for NPR1/NH1-mediated
CC resistance to the bacterial blight pathogen Xanthomomas oryzae pv.
CC oryzae (Xoo). Required for pathogenesis-related (PR) genes expression.
CC May be involved in lignin biosynthesis. {ECO:0000269|PubMed:20862311}.
CC -!- DISRUPTION PHENOTYPE: No visible phenotype under normal growth
CC conditions, but mutant plants have reduced lignin content and increased
CC sugar extractability. Mutant plants show enhanced susceptibility to the
CC bacterial blight pathogen Xanthomomas oryzae pv. oryzae (Xoo).
CC {ECO:0000269|PubMed:20862311}.
CC -!- SIMILARITY: Belongs to the 3-beta-HSD family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAD68587.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=BAD68588.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=BAD68953.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=BAD68954.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AP003607; BAD68587.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AP003607; BAD68588.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AP004367; BAD68953.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AP004367; BAD68954.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AP008207; BAF05588.1; -; Genomic_DNA.
DR EMBL; AP014957; BAS73357.1; -; Genomic_DNA.
DR RefSeq; XP_015621328.1; XM_015765842.1.
DR AlphaFoldDB; Q0JKZ0; -.
DR SMR; Q0JKZ0; -.
DR STRING; 4530.OS01T0639200-00; -.
DR PaxDb; Q0JKZ0; -.
DR PRIDE; Q0JKZ0; -.
DR EnsemblPlants; Os01t0639200-01; Os01t0639200-01; Os01g0639200.
DR GeneID; 4326581; -.
DR Gramene; Os01t0639200-01; Os01t0639200-01; Os01g0639200.
DR KEGG; osa:4326581; -.
DR eggNOG; KOG1502; Eukaryota.
DR HOGENOM; CLU_007383_9_1_1; -.
DR InParanoid; Q0JKZ0; -.
DR OMA; FELCRQK; -.
DR OrthoDB; 992332at2759; -.
DR Proteomes; UP000000763; Chromosome 1.
DR Proteomes; UP000059680; Chromosome 1.
DR GO; GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IBA:GO_Central.
DR GO; GO:0042742; P:defense response to bacterium; IMP:UniProtKB.
DR GO; GO:0009809; P:lignin biosynthetic process; IMP:UniProtKB.
DR GO; GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
DR InterPro; IPR002225; 3Beta_OHSteriod_DH/Estase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR Pfam; PF01073; 3Beta_HSD; 1.
DR SUPFAM; SSF51735; SSF51735; 1.
PE 3: Inferred from homology;
KW Lignin biosynthesis; NADP; Oxidoreductase; Plant defense;
KW Reference proteome.
FT CHAIN 1..379
FT /note="Cinnamoyl-CoA reductase-like SNL6"
FT /id="PRO_0000437026"
FT ACT_SITE 226
FT /note="Proton donor"
FT /evidence="ECO:0000250|UniProtKB:Q12068"
FT BINDING 66..72
FT /ligand="NADP(+)"
FT /ligand_id="ChEBI:CHEBI:58349"
FT /evidence="ECO:0000250|UniProtKB:P51110"
FT BINDING 98
FT /ligand="NADP(+)"
FT /ligand_id="ChEBI:CHEBI:58349"
FT /evidence="ECO:0000250|UniProtKB:P51110"
FT BINDING 119..120
FT /ligand="NADP(+)"
FT /ligand_id="ChEBI:CHEBI:58349"
FT /evidence="ECO:0000250|UniProtKB:P51110"
FT BINDING 139..141
FT /ligand="NADP(+)"
FT /ligand_id="ChEBI:CHEBI:58349"
FT /evidence="ECO:0000250|UniProtKB:P51110"
FT BINDING 226
FT /ligand="NADP(+)"
FT /ligand_id="ChEBI:CHEBI:58349"
FT /evidence="ECO:0000250|UniProtKB:P51110"
FT BINDING 249..252
FT /ligand="NADP(+)"
FT /ligand_id="ChEBI:CHEBI:58349"
FT /evidence="ECO:0000250|UniProtKB:P51110"
SQ SEQUENCE 379 AA; 41261 MW; 45773233C6A3AA4D CRC64;
MGVLRSTQSM QAEVEEMRAA LLHGHGGGAA AAAAAGWRPS AGDADVKRTA GGDGGAAGPR
TVCVTGGISF VGFAVVDRLL RHGYTVRLAL ETQEDLDKLR EMEMFGEDGR DGVWTVMANV
TDPESLHRAF DGCAGVFHTS AFVDPGGMSG YTKHMASLEA KAAEQVIEAC VRTESVRKCV
FTSSLLACVW RQNYPHDRRF PTIIDENCWS DESFCRDNKL WFALGKTAAE KTAWRAARGR
DLKLVTVCPA LVTGPGFRRR NSTASIAYLK GARAMLADGL LATASVETVA EAHVRVYEAM
GDNTAGGRYI CYDHVVKRPE EFAELERQLG IPRRAAAAAA AQDSGDRPAR FDLCRQKLAR
LMSTRRRCTY DDYYSVAFD
