SNMP1_AEDAE
ID SNMP1_AEDAE Reviewed; 540 AA.
AC Q17A88; A9LME1;
DT 03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT 18-SEP-2013, sequence version 2.
DT 25-MAY-2022, entry version 76.
DE RecName: Full=Sensory neuron membrane protein 1 {ECO:0000303|PubMed:19364529, ECO:0000312|EMBL:ACK99697.1};
DE Short=SNMP1Aaeg {ECO:0000303|PubMed:19364529};
DE AltName: Full=Scavenger receptor class B;
GN Name=snmp1 {ECO:0000303|PubMed:19364529, ECO:0000312|EMBL:ABX10906.1};
GN Synonyms=SCRB1; ORFNames=AAEL005374;
OS Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Aedini; Aedes; Stegomyia.
OX NCBI_TaxID=7159;
RN [1] {ECO:0000312|EMBL:ACK99697.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 2).
RX PubMed=19364529; DOI=10.1016/j.ibmb.2009.03.007;
RA Vogt R.G., Miller N.E., Litvack R., Fandino R.A., Sparks J., Staples J.,
RA Friedman R., Dickens J.C.;
RT "The insect SNMP gene family.";
RL Insect Biochem. Mol. Biol. 39:448-456(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LVPib12;
RX PubMed=17510324; DOI=10.1126/science.1138878;
RA Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F.,
RA Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.,
RA Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L.,
RA Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J.,
RA Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E.,
RA El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I.,
RA Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H.,
RA Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S.,
RA Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P.,
RA Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R.,
RA Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B.,
RA Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T.,
RA Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.;
RT "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL Science 316:1718-1723(2007).
CC -!- FUNCTION: Plays an olfactory role that is not restricted to pheromone
CC sensitivity. {ECO:0000250|UniProtKB:Q9VDD3}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:O02351};
CC Multi-pass membrane protein {ECO:0000250|UniProtKB:O02351}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q17A88-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q17A88-2; Sequence=VSP_047714;
CC -!- SIMILARITY: Belongs to the CD36 family. {ECO:0000305}.
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DR EMBL; EU246941; ABX10906.1; -; mRNA.
DR EMBL; FJ387158; ACK99697.1; -; Genomic_DNA.
DR EMBL; CH477338; EAT43165.2; -; Genomic_DNA.
DR RefSeq; XP_001650804.2; XM_001650754.2.
DR AlphaFoldDB; Q17A88; -.
DR SMR; Q17A88; -.
DR STRING; 7159.AAEL005374-PA; -.
DR VEuPathDB; VectorBase:AAEL005374; -.
DR eggNOG; KOG3776; Eukaryota.
DR HOGENOM; CLU_019853_1_2_1; -.
DR InParanoid; Q17A88; -.
DR OMA; KFMISKQ; -.
DR OrthoDB; 1106566at2759; -.
DR PhylomeDB; Q17A88; -.
DR Proteomes; UP000008820; Unassembled WGS sequence.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
DR GO; GO:0007608; P:sensory perception of smell; IEA:UniProtKB-KW.
DR InterPro; IPR002159; CD36_fam.
DR PANTHER; PTHR11923; PTHR11923; 1.
DR Pfam; PF01130; CD36; 1.
DR PRINTS; PR01609; CD36FAMILY.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell membrane; Disulfide bond; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..540
FT /note="Sensory neuron membrane protein 1"
FT /id="PRO_0000408230"
FT TOPO_DOM 1..105
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 106..126
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 127..436
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 437..457
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 458..540
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 193
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 206
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 418
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 245..310
FT /evidence="ECO:0000250"
FT DISULFID 274..330
FT /evidence="ECO:0000250"
FT DISULFID 312..319
FT /evidence="ECO:0000250"
FT VAR_SEQ 1..17
FT /note="MRTDDPVIGNDGDAPRY -> MLIKNR (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:19364529"
FT /id="VSP_047714"
FT CONFLICT 61
FT /note="R -> H (in Ref. 1; ABX10906)"
FT /evidence="ECO:0000305"
FT CONFLICT 103
FT /note="S -> T (in Ref. 1; ABX10906)"
FT /evidence="ECO:0000305"
FT CONFLICT 172
FT /note="H -> Q (in Ref. 1; ABX10906)"
FT /evidence="ECO:0000305"
FT CONFLICT 465
FT /note="M -> T (in Ref. 1; ABX10906)"
FT /evidence="ECO:0000305"
FT CONFLICT 482
FT /note="K -> N (in Ref. 1; ABX10906)"
FT /evidence="ECO:0000305"
FT CONFLICT 502
FT /note="A -> T (in Ref. 1; ABX10906)"
FT /evidence="ECO:0000305"
FT CONFLICT 527
FT /note="K -> R (in Ref. 1; ABX10906)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 540 AA; 60273 MW; 1A1174189E55CEF7 CRC64;
MRTDDPVIGN DGDAPRYKNL MLKPGTQMRG MFEKIPFPLD FKLYLFHVTN PDVVMKGGKP
RVREIGPYFF EEWKEKYDTV DNEEDDTLTF TLKNTWIFRP DLSKPLTGDE MITIPHPLIL
GALLMVQRDR EAMMPLVSKG MDIIMNPLTT GFLTTRVMDL LFDGILIDCS SHEFSAKALC
SGLESEGAVM PFNETHFKFS MFGLKNGTDA GRWVVYRGVK NIMDLGRVVS FNDETEMDIY
DGDECNRYIG TDSTIFPPFL TTKDKLWAWS PEICRSIGAE YGGKSKYAGL PMSFFKLDFG
DARNEPEHHC FCRDPPDICP PKGTIDLAPC LGAPIIGSKP HFYDSDPKLL AAVDGLTPNE
KDHDVYIHFQ LLSGTPVSAA KRLMFSMEIE PIRDHAVLGN LPTVILPLFW AEEGASLNKT
WTNQLKYTLF LGLRFNTAVK WLTIIIGTIG TIVGGFMHYK RTTKMVNVTP VQSVNGSSAK
GKGAGMTVVG HQPDSKGGSV TAPVIPSAKD LLQNSRNLPT VIEGLDKPQK VTVTEMQERY
