SNMP1_ANOGA
ID SNMP1_ANOGA Reviewed; 545 AA.
AC Q7QC49; Q7QC47;
DT 03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT 18-APR-2012, sequence version 3.
DT 25-MAY-2022, entry version 82.
DE RecName: Full=Sensory neuron membrane protein 1 {ECO:0000303|PubMed:18342246};
DE AltName: Full=Scavenger receptor class B;
GN Name=snmp1; Synonyms=SCRB1; ORFNames=AGAP002451;
OS Anopheles gambiae (African malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7165;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PEST;
RX PubMed=12364791; DOI=10.1126/science.1076181;
RA Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z.,
RA Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W.,
RA Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C.,
RA Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K.,
RA Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V.,
RA Dana A., Delcher A., Dew I., Evans C.A., Flanigan M.,
RA Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R.,
RA Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J.,
RA Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I.,
RA Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A.,
RA McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D.,
RA O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H.,
RA Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J.,
RA Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B.,
RA Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M.,
RA Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J.,
RA Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M.,
RA Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C.,
RA Collins F.H., Hoffman S.L.;
RT "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL Science 298:129-149(2002).
RN [2] {ECO:0000305}
RP TISSUE SPECIFICITY.
RX PubMed=17943085; DOI=10.1038/nature06328;
RA Benton R., Vannice K.S., Vosshall L.B.;
RT "An essential role for a CD36-related receptor in pheromone detection in
RT Drosophila.";
RL Nature 450:289-293(2007).
RN [3] {ECO:0000305}
RP IDENTIFICATION.
RX PubMed=18342246; DOI=10.1016/j.ibmb.2007.11.003;
RA Nichols Z., Vogt R.G.;
RT "The SNMP/CD36 gene family in Diptera, Hymenoptera and Coleoptera:
RT Drosophila melanogaster, D. pseudoobscura, Anopheles gambiae, Aedes
RT aegypti, Apis mellifera, and Tribolium castaneum.";
RL Insect Biochem. Mol. Biol. 38:398-415(2008).
CC -!- FUNCTION: Plays an olfactory role that is not restricted to pheromone
CC sensitivity. {ECO:0000250|UniProtKB:Q9VDD3}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:O02351};
CC Multi-pass membrane protein {ECO:0000250|UniProtKB:O02351}.
CC -!- TISSUE SPECIFICITY: Selectively expressed in antenna.
CC {ECO:0000269|PubMed:17943085}.
CC -!- SIMILARITY: Belongs to the CD36 family. {ECO:0000305}.
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DR EMBL; AAAB01008859; EAA07986.4; -; Genomic_DNA.
DR RefSeq; XP_312496.4; XM_312496.4.
DR AlphaFoldDB; Q7QC49; -.
DR SMR; Q7QC49; -.
DR STRING; 7165.AGAP002451-PA; -.
DR PaxDb; Q7QC49; -.
DR GeneID; 1273513; -.
DR KEGG; aga:AgaP_AGAP002451; -.
DR CTD; 1273513; -.
DR VEuPathDB; VectorBase:AGAP002451; -.
DR eggNOG; KOG3776; Eukaryota.
DR HOGENOM; CLU_019853_1_2_1; -.
DR InParanoid; Q7QC49; -.
DR OMA; KFMISKQ; -.
DR OrthoDB; 1106566at2759; -.
DR PhylomeDB; Q7QC49; -.
DR Proteomes; UP000007062; Chromosome 2R.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005044; F:scavenger receptor activity; IBA:GO_Central.
DR GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
DR GO; GO:0007608; P:sensory perception of smell; IEA:UniProtKB-KW.
DR InterPro; IPR002159; CD36_fam.
DR PANTHER; PTHR11923; PTHR11923; 1.
DR Pfam; PF01130; CD36; 1.
DR PRINTS; PR01609; CD36FAMILY.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; Glycoprotein; Membrane; Olfaction; Receptor;
KW Reference proteome; Sensory transduction; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..545
FT /note="Sensory neuron membrane protein 1"
FT /id="PRO_0000408231"
FT TOPO_DOM 1..10
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 11..31
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 32..464
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 465..485
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 486..545
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 69
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 214
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 227
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 444
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 462
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 266..331
FT /evidence="ECO:0000250|UniProtKB:P26201"
FT DISULFID 295..351
FT /evidence="ECO:0000250|UniProtKB:P26201"
FT DISULFID 333..340
FT /evidence="ECO:0000250|UniProtKB:P26201"
SQ SEQUENCE 545 AA; 61611 MW; D95B1687E48CD7C9 CRC64;
MELKERNFKK IGLICVAVLL CGMVFSYGIF PSILRFMIKQ NVLLKPGTQI RDMFEKIPFP
LDFKLHIFNV TNPDEIMRGG KPRVNDIGPL YFEEWKEKYD TVDNVEEDTL TFTLRNTWIF
RPDLSALTGE EIVTIPHPLI MGVLLMVQRD REAMMPLVKK GVNILFDPLE SAFLKVRIMD
LLFDGIYVDC SSQDFAAKAL CSGMDSEGAV MPHNETHYKF SFFGMRNHTE AGRWVVYRGV
KNIRDLGRVV SYNEETEMDI WDGDECNQYI GTDSTIFPPF LTAQDRLWAW SPEICRSLGA
HYVHKSKYAG LPMSYFELDF GDLKNEPHNH CFCRDAPDDC PPKGTMDLSP CLGGPIIGSK
PHFYGADPKL VEAVDGLAPN KAAHDVYIHF ELASICWFTG SPVSAAKRLQ FSMELGPIRD
HELFGQLPDV ILPMFWAEEG ASLNKTWTNQ LKYQLFLGLK FNATVKWLTI IIGTVGAVGS
AYMYFRKETK TTDVAPVDVS TPDTNPSSAK DGVVNVSLGR NLPPVIDGLD KPPKLRATEL
QQERY
