SNMP1_DROME
ID SNMP1_DROME Reviewed; 551 AA.
AC Q9VDD3; A5JS49; A5JS50; A5YWL9;
DT 03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 2.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Sensory neuron membrane protein 1 {ECO:0000303|PubMed:17943085, ECO:0000303|PubMed:18653762, ECO:0000303|PubMed:19364529, ECO:0000312|EMBL:AAF55863.2};
DE Short=SNMP1Dmel {ECO:0000303|PubMed:19364529};
GN Name=Snmp1 {ECO:0000303|PubMed:19364529}; ORFNames=CG7000;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1] {ECO:0000312|EMBL:AAF55863.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2] {ECO:0000305, ECO:0000312|EMBL:AAF55863.2}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3] {ECO:0000312|EMBL:ABC86348.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley;
RA Stapleton M., Carlson J., Chavez C., Frise E., George R., Pacleb J.,
RA Park S., Wan K., Yu C., Celniker S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000305, ECO:0000312|EMBL:ABQ96635.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] OF 190-367.
RC STRAIN=W1118 {ECO:0000312|EMBL:ABQ96635.1};
RC TISSUE=Head {ECO:0000312|EMBL:ABQ96635.1},
RC Limb {ECO:0000312|EMBL:ABQ42604.1}, and Wing {ECO:0000312|EMBL:ABQ42605.1};
RX PubMed=19364529; DOI=10.1016/j.ibmb.2009.03.007;
RA Vogt R.G., Miller N.E., Litvack R., Fandino R.A., Sparks J., Staples J.,
RA Friedman R., Dickens J.C.;
RT "The insect SNMP gene family.";
RL Insect Biochem. Mol. Biol. 39:448-456(2009).
RN [5] {ECO:0000305}
RP FUNCTION, TISSUE SPECIFICITY, AND DISRUPTION PHENOTYPE.
RX PubMed=17943085; DOI=10.1038/nature06328;
RA Benton R., Vannice K.S., Vosshall L.B.;
RT "An essential role for a CD36-related receptor in pheromone detection in
RT Drosophila.";
RL Nature 450:289-293(2007).
RN [6] {ECO:0000305}
RP FUNCTION.
RX PubMed=18653762; DOI=10.1073/pnas.0803309105;
RA Jin X., Ha T.S., Smith D.P.;
RT "SNMP is a signaling component required for pheromone sensitivity in
RT Drosophila.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10996-11001(2008).
RN [7]
RP DEVELOPMENTAL STAGE.
RX PubMed=21948708; DOI=10.1387/ijdb.103254lh;
RA Herboso L., Talamillo A., Perez C., Barrio R.;
RT "Expression of the Scavenger Receptor Class B type I (SR-BI) family in
RT Drosophila melanogaster.";
RL Int. J. Dev. Biol. 55:603-611(2011).
CC -!- FUNCTION: Plays an olfactory role that is not restricted to pheromone
CC sensitivity. Has a role in detection and signal transduction of the
CC fatty-acid-derived male pheromone 11-cis vaccenyl acetate (cVA). Not
CC required for sensitivity to general odorants. Acts in concert with
CC Or67d and lush to capture cVA molecules on the surface of Or67d
CC expressing olfactory dendrites and facilitate their transfer to the
CC odorant-receptor Orco complex. Essential for the electrophysiological
CC responses of these olfactory sensory neurons (OSNs) to cVA. Not
CC required for the development of trichoid OSNs and support cells.
CC {ECO:0000269|PubMed:17943085, ECO:0000269|PubMed:18653762}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:O02351};
CC Multi-pass membrane protein {ECO:0000250|UniProtKB:O02351}.
CC -!- TISSUE SPECIFICITY: Selectively expressed in antenna. Expressed in
CC lateral-distal population of OSNs that coexpress Orco, in non-neuronal
CC support cells that surround these OSNs, in support cells elsewhere in
CC the antenna and chemosensory organs on the proboscis. Expressed in
CC trichoid sensory cilia (at protein level).
CC {ECO:0000269|PubMed:17943085}.
CC -!- DEVELOPMENTAL STAGE: In L3 instar larvae, expression increases with
CC development. Expressed in the ring gland. Ubiquitously expressed in the
CC testis whereas in the ovary expression appears to be restricted to one
CC pole. Weak expression in the Garland cells, salivary glands and the
CC central nervous system. {ECO:0000269|PubMed:21948708}.
CC -!- DISRUPTION PHENOTYPE: Mutants are viable and fertile with no gross
CC morphological or locomotor defects. {ECO:0000269|PubMed:17943085}.
CC -!- SIMILARITY: Belongs to the CD36 family. {ECO:0000305}.
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DR EMBL; AE014297; AAF55863.2; -; Genomic_DNA.
DR EMBL; BT024286; ABC86348.1; -; mRNA.
DR EMBL; EF560170; ABQ42604.1; -; mRNA.
DR EMBL; EF560171; ABQ42605.1; -; mRNA.
DR EMBL; EF596938; ABQ96635.1; -; Genomic_DNA.
DR RefSeq; NP_001262803.1; NM_001275874.1.
DR RefSeq; NP_650953.1; NM_142696.3.
DR AlphaFoldDB; Q9VDD3; -.
DR SMR; Q9VDD3; -.
DR BioGRID; 67484; 5.
DR IntAct; Q9VDD3; 1.
DR STRING; 7227.FBpp0306056; -.
DR TCDB; 9.B.39.1.6; the long chain fatty acid translocase (lcfat) family.
DR GlyGen; Q9VDD3; 4 sites.
DR PaxDb; Q9VDD3; -.
DR PRIDE; Q9VDD3; -.
DR DNASU; 42514; -.
DR EnsemblMetazoa; FBtr0084027; FBpp0083430; FBgn0260004.
DR EnsemblMetazoa; FBtr0333928; FBpp0306056; FBgn0260004.
DR GeneID; 42514; -.
DR KEGG; dme:Dmel_CG7000; -.
DR UCSC; CG7000-RA; d. melanogaster.
DR CTD; 42514; -.
DR FlyBase; FBgn0260004; Snmp1.
DR VEuPathDB; VectorBase:FBgn0260004; -.
DR eggNOG; KOG3776; Eukaryota.
DR GeneTree; ENSGT00940000153372; -.
DR HOGENOM; CLU_019853_1_2_1; -.
DR InParanoid; Q9VDD3; -.
DR OMA; KFMISKQ; -.
DR OrthoDB; 1106566at2759; -.
DR PhylomeDB; Q9VDD3; -.
DR BioGRID-ORCS; 42514; 0 hits in 3 CRISPR screens.
DR ChiTaRS; Snmp1; fly.
DR GenomeRNAi; 42514; -.
DR PRO; PR:Q9VDD3; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0260004; Expressed in second segment of antenna (Drosophila) and 22 other tissues.
DR ExpressionAtlas; Q9VDD3; baseline and differential.
DR Genevisible; Q9VDD3; DM.
DR GO; GO:0005929; C:cilium; IDA:FlyBase.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0030425; C:dendrite; IDA:FlyBase.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0043025; C:neuronal cell body; IDA:FlyBase.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005044; F:scavenger receptor activity; IBA:GO_Central.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IMP:FlyBase.
DR GO; GO:0071444; P:cellular response to pheromone; IMP:FlyBase.
DR GO; GO:0050911; P:detection of chemical stimulus involved in sensory perception of smell; IMP:FlyBase.
DR GO; GO:0055088; P:lipid homeostasis; IMP:FlyBase.
DR GO; GO:0035073; P:pupariation; IMP:FlyBase.
DR GO; GO:0019236; P:response to pheromone; IMP:FlyBase.
DR InterPro; IPR005428; CD36/SCARB1/SNMP1.
DR InterPro; IPR002159; CD36_fam.
DR PANTHER; PTHR11923; PTHR11923; 1.
DR Pfam; PF01130; CD36; 1.
DR PRINTS; PR01610; CD36ANTIGEN.
DR PRINTS; PR01609; CD36FAMILY.
PE 1: Evidence at protein level;
KW Cell membrane; Disulfide bond; Glycoprotein; Membrane; Olfaction; Receptor;
KW Reference proteome; Sensory transduction; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..551
FT /note="Sensory neuron membrane protein 1"
FT /id="PRO_0000408239"
FT TOPO_DOM 1..7
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 8..28
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 29..459
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 460..480
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 481..551
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 503..551
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 509..540
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 66
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 213
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 226
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 440
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 265..330
FT /evidence="ECO:0000250|UniProtKB:P26201"
FT DISULFID 294..352
FT /evidence="ECO:0000250|UniProtKB:P26201"
FT DISULFID 332..341
FT /evidence="ECO:0000250|UniProtKB:P26201"
SQ SEQUENCE 551 AA; 62117 MW; EB58ECD3B5A7158C CRC64;
MQVPRVKLLM GSGAMFVFAI IYGWVIFPKI LKFMISKQVT LKPGSDVREL WSNTPFPLHF
YIYVFNVTNP DEVSEGAKPR LQEVGPFVFD EWKDKYDLED DVVEDTVSFT MRNTFIFNPK
ESLPLTGEEE IILPHPIMLP GGISVQREKA AMMELVSKGL SIVFPDAKAF LKAKFMDLFF
RGINVDCSSE EFSAKALCTV FYTGEIKQAK QVNQTHFLFS FMGQANHSDS GRFTVCRGVK
NNKKLGKVVK FADEPEQDIW PDGECNTFVG TDSTVFAPGL KKEDGLWAFT PDLCRSLGAY
YQHKSSYHGM PSMRYTLDLG DIRADEKLHC FCEDPEDLDT CPPKGTMNLA ACVGGPLMAS
MPHFYLGDPK LVADVDGLNP NEKDHAVYID FELMSGTPFQ AAKRLQFNLD MEPVEGIEPM
KNLPKLILPM FWVEEGVQLN KTYTNLVKYT LFLGLKINSV LRWSLITFSL VGLMFSAYLF
YHKSDSLDIN SILKDNNKVD DVASTKEPLP SANPKQSSTV HPVQLPNTLI PGTNPATNPA
THHKMEHRER Y
