ID   SNMP1_MANSE             Reviewed;         523 AA.
AC   Q9GPH7;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   25-MAY-2022, entry version 39.
DE   RecName: Full=Sensory neuron membrane protein 1 {ECO:0000312|EMBL:AAG49366.1};
DE            Short=SNMP1-Msex {ECO:0000303|PubMed:11536197};
OS   Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Bombycoidea;
OC   Sphingidae; Sphinginae; Sphingini; Manduca.
OX   NCBI_TaxID=7130;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:AAG49366.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RC   TISSUE=Antenna {ECO:0000312|EMBL:AAG49366.1};
RX   PubMed=11536197; DOI=10.1002/neu.1065;
RA   Rogers M.E., Krieger J., Vogt R.G.;
RT   "Antennal SNMPs (sensory neuron membrane proteins) of Lepidoptera define a
RT   unique family of invertebrate CD36-like proteins.";
RL   J. Neurobiol. 49:47-61(2001).
CC   -!- FUNCTION: Plays an olfactory role that is not restricted to pheromone
CC       sensitivity. {ECO:0000250|UniProtKB:O02351}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:O02351};
CC       Multi-pass membrane protein {ECO:0000250|UniProtKB:O02351}.
CC   -!- TISSUE SPECIFICITY: Localizes to both male and female antennae but not
CC       the leg, wing, gut, head, or thoracic ganglia. Detected throughout the
CC       sensory epithelium, associating with both sex-pheromone sensilla and
CC       plant-volatile sensilla. Differentially expressed both among different
CC       sensilla and different neurons within a given sensillum. Expression
CC       coincides with that of several other olfactory-specific proteins that
CC       are involved in odor detection. {ECO:0000269|PubMed:11536197}.
CC   -!- DEVELOPMENTAL STAGE: Detected at very low levels 48 hours before adult
CC       emergence. Levels dramatically increase around 24 hours prior to
CC       emergence and are subsequently maintained at a similar level in both
CC       newly emerged animals as well as in animals 24 hours postemergence.
CC       {ECO:0000269|PubMed:11536197}.
CC   -!- SIMILARITY: Belongs to the CD36 family. {ECO:0000305}.
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DR   EMBL; AF323589; AAG49366.1; -; mRNA.
DR   AlphaFoldDB; Q9GPH7; -.
DR   SMR; Q9GPH7; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
DR   GO; GO:0007608; P:sensory perception of smell; IEA:UniProtKB-KW.
DR   InterPro; IPR002159; CD36_fam.
DR   PANTHER; PTHR11923; PTHR11923; 1.
DR   Pfam; PF01130; CD36; 1.
DR   PRINTS; PR01609; CD36FAMILY.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; Glycoprotein; Membrane; Olfaction; Receptor;
KW   Sensory transduction; Transmembrane; Transmembrane helix.
FT   CHAIN           1..523
FT                   /note="Sensory neuron membrane protein 1"
FT                   /id="PRO_0000408252"
FT   TOPO_DOM        1..10
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        11..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        32..458
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        459..479
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        480..523
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          499..523
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        67
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        229
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        440
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        268..333
FT                   /evidence="ECO:0000250|UniProtKB:P26201"
FT   DISULFID        297..352
FT                   /evidence="ECO:0000250|UniProtKB:P26201"
FT   DISULFID        335..341
FT                   /evidence="ECO:0000250|UniProtKB:P26201"
SQ   SEQUENCE   523 AA;  59588 MW;  07B1E6073CD6AF21 CRC64;
     MRLARGIKYA VIGAGVALFG VLFGWVMFPA ILKSQLKKEM ALSKKTDVRK MWEKIPFALD
     FKIYLFNYTN PEEVQKGAAP IVKEVGPYYF EEWKEKVEIE DHEEDDTITY RKMDTFYFRP
     ELSGPGLTGE ETIIMPHVFM MSMAITVYRD KPSMMNMLGK AINGIFDNPS DVFMRVNAMD
     ILFRGVIINC DRTEFAPKAA CTAIKKEGAK SLIIEPNNQL RFSLFGLKNH TVDSRVVTVK
     RGIKNVMDVG QVVAMDGAPQ LEIWNDHCNE YQGTDGTIFP PFLTQKDRLQ SYSADLCRSF
     KPWFQKTTYY RGIKTNHYIA NMGDFANDPE LNCFCETPEK CPPKGLMDLT KCVKAPMYAS
     MPHFLDADPQ MLENVKGLNP DMNEHGIQID FEPISGTPMM AKQRVQFNME LLRVEKIEIM
     KELPGYIVPL LWIEGGLALN KTFVKMLKNQ LFIPKRIVSV IRWWLLSFGM LAALGGVIFH
     FKDDIMRIAI KGDSSVTKVN PEDGEQKDVS VIGQSHEPPK INM