SNMP2_AEDAE
ID SNMP2_AEDAE Reviewed; 542 AA.
AC C3U0S3; A8W3N6; Q177Z2;
DT 25-JAN-2012, integrated into UniProtKB/Swiss-Prot.
DT 18-SEP-2013, sequence version 3.
DT 25-MAY-2022, entry version 50.
DE RecName: Full=Sensory neuron membrane protein 2 {ECO:0000303|PubMed:19364529, ECO:0000312|EMBL:ACK99698.1};
DE Short=SNMP2Aaeg {ECO:0000303|PubMed:19364529};
GN Name=snmp2 {ECO:0000312|EMBL:ABW70128.1}; Synonyms=SCRB16;
GN ORFNames=AAEL005981;
OS Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Aedini; Aedes; Stegomyia.
OX NCBI_TaxID=7159;
RN [1] {ECO:0000305, ECO:0000312|EMBL:ACK99698.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1), AND TISSUE
RP SPECIFICITY.
RX PubMed=19364529; DOI=10.1016/j.ibmb.2009.03.007;
RA Vogt R.G., Miller N.E., Litvack R., Fandino R.A., Sparks J., Staples J.,
RA Friedman R., Dickens J.C.;
RT "The insect SNMP gene family.";
RL Insect Biochem. Mol. Biol. 39:448-456(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LVPib12;
RX PubMed=17510324; DOI=10.1126/science.1138878;
RA Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F.,
RA Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.,
RA Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L.,
RA Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J.,
RA Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E.,
RA El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I.,
RA Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H.,
RA Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S.,
RA Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P.,
RA Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R.,
RA Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B.,
RA Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T.,
RA Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.;
RT "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL Science 316:1718-1723(2007).
CC -!- FUNCTION: Plays an olfactory role that is not restricted to pheromone
CC sensitivity. {ECO:0000250|UniProtKB:O02351}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=C3U0S3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=C3U0S3-2; Sequence=VSP_047868;
CC -!- TISSUE SPECIFICITY: Detected in the antenna, legs and wings. Higher
CC levels of expression detected in male compared to female.
CC {ECO:0000269|PubMed:19364529}.
CC -!- SIMILARITY: Belongs to the CD36 family. {ECO:0000255}.
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DR EMBL; EU189151; ABW70128.1; -; mRNA.
DR EMBL; FJ387159; ACK99698.1; -; Genomic_DNA.
DR EMBL; CH477368; EAT42492.2; -; Genomic_DNA.
DR RefSeq; XP_001664331.2; XM_001664281.2.
DR AlphaFoldDB; C3U0S3; -.
DR SMR; C3U0S3; -.
DR STRING; 7159.AAEL005981-PA; -.
DR PRIDE; C3U0S3; -.
DR VEuPathDB; VectorBase:AAEL019436; -.
DR eggNOG; KOG3776; Eukaryota.
DR InParanoid; C3U0S3; -.
DR Proteomes; UP000008820; Chromosome 2.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
DR GO; GO:0007608; P:sensory perception of smell; IEA:UniProtKB-KW.
DR InterPro; IPR002159; CD36_fam.
DR PANTHER; PTHR11923; PTHR11923; 1.
DR Pfam; PF01130; CD36; 1.
DR PRINTS; PR01609; CD36FAMILY.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell membrane; Disulfide bond; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..542
FT /note="Sensory neuron membrane protein 2"
FT /id="PRO_0000414926"
FT TOPO_DOM 1..487
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 488..508
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 509..542
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 33
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 128
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 238
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 274
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 283..351
FT /evidence="ECO:0000250"
FT DISULFID 312..378
FT /evidence="ECO:0000250"
FT DISULFID 353..367
FT /evidence="ECO:0000250"
FT VAR_SEQ 111..155
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_047868"
FT CONFLICT 60
FT /note="R -> C (in Ref. 1; ABW70128)"
FT /evidence="ECO:0000305"
FT CONFLICT 511
FT /note="R -> K (in Ref. 1; ABW70128)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 542 AA; 61707 MW; 1366FB404AE02799 CRC64;
MMVMNTELRQ DTPQFKRWEA VPQPLDFKVY IFNVTNPYEV QMGRRPRVVE VGPYVYFQYR
HKDNIRFSRD RSKVHFSQQQ MYVFDAESSY PLTENDQLTV LNMHMNSILQ IIDTQAKETI
TNFRSDVNNT LEKIPVVRVI KRIIEKTTPI QSILQLAEDE TYDSLRLINA ELNRIFGRPD
SMFLRTTPRE FLFEGVPFCV NVIGIAKAIC KEIEKRNTKT IRVQPDGSMK FSFFNHKNMT
NDGTYTINTG IKEPALTQMI EYWNGRNTLD RWINQSAGSS SKCNKIVGTD GSGYPPFREG
VERMTIFSSD ICRTVDIKYV GPSSYEGIPA LRFETDSHFL NEIGPEYGND CYCVNRIPKA
IVKNNGCLYK GALDLSTCFD APVVLTHPHM MGAAQEYTSL IDGLYPDPEK HQIFVDVEPL
TGTPLNGGKR VQFNMFLRRI DSIRLTDRLQ TTLFPVLWIE EGIALNEDMV KLIDDSLMKV
LTLLDIVQWV MIGSGLLLAI IMPIVYFIKR RPSSGSITPT LTTTTSTVSI SDGGGLGGNP
QK
