SNMP2_DROME
ID SNMP2_DROME Reviewed; 556 AA.
AC E1JI63; A0AVW0; A1A6X6; A1A6X7; A1A6Z5; A1A6Z6; A2RVH7; A8W3N7; C9QPB5;
AC Q0E8H2;
DT 25-JAN-2012, integrated into UniProtKB/Swiss-Prot.
DT 30-NOV-2010, sequence version 1.
DT 03-AUG-2022, entry version 74.
DE RecName: Full=Sensory neuron membrane protein 2 {ECO:0000303|PubMed:19364529, ECO:0000312|EMBL:ABW70129.1};
DE Short=SNMP2Dmel {ECO:0000303|PubMed:19364529};
GN Name=Snmp2 {ECO:0000312|EMBL:ABW70129.1}; ORFNames=CG7422;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1] {ECO:0000305, ECO:0000312|EMBL:ABW70129.1}
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM C), AND TISSUE SPECIFICITY.
RX PubMed=19364529; DOI=10.1016/j.ibmb.2009.03.007;
RA Vogt R.G., Miller N.E., Litvack R., Fandino R.A., Sparks J., Staples J.,
RA Friedman R., Dickens J.C.;
RT "The insect SNMP gene family.";
RL Insect Biochem. Mol. Biol. 39:448-456(2009).
RN [2] {ECO:0000312|EMBL:ACZ94643.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3] {ECO:0000305, ECO:0000312|EMBL:ACZ94643.1}
RP GENOME REANNOTATION, AND ALTERNATIVE SPLICING.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4] {ECO:0000305, ECO:0000312|EMBL:ABL75707.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM C).
RC STRAIN=Berkeley;
RA Stapleton M., Carlson J., Booth B., Frise E., Kapadia B., Park S., Wan K.,
RA Yu C., Celniker S.;
RL Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Plays an olfactory role that is not restricted to pheromone
CC sensitivity. {ECO:0000250|UniProtKB:O02351}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:O02351};
CC Multi-pass membrane protein {ECO:0000250|UniProtKB:O02351}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=C {ECO:0000269|PubMed:10731132};
CC IsoId=E1JI63-1; Sequence=Displayed;
CC Name=B {ECO:0000269|PubMed:10731132};
CC IsoId=E1JI63-2; Sequence=VSP_042166;
CC -!- TISSUE SPECIFICITY: Detected in the head and to a lesser extent in legs
CC and wings. {ECO:0000269|PubMed:19364529}.
CC -!- SIMILARITY: Belongs to the CD36 family. {ECO:0000255}.
CC -!- SEQUENCE CAUTION:
CC Sequence=ABK30915.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};
CC Sequence=ABL75706.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=ABL75707.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=ABL75707.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};
CC Sequence=ACX54881.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; EU189152; ABW70129.1; -; mRNA.
DR EMBL; AE014296; ABI31242.1; -; Genomic_DNA.
DR EMBL; AE014296; ACZ94643.1; -; Genomic_DNA.
DR EMBL; BT029278; ABK30915.1; ALT_SEQ; mRNA.
DR EMBL; BT029647; ABL75706.1; ALT_FRAME; mRNA.
DR EMBL; BT029648; ABL75707.1; ALT_SEQ; mRNA.
DR EMBL; BT029668; ABL75725.1; -; mRNA.
DR EMBL; BT029968; ABM92842.1; -; mRNA.
DR EMBL; BT029669; ABL75726.1; -; mRNA.
DR EMBL; BT099997; ACX54881.1; ALT_FRAME; mRNA.
DR RefSeq; NP_001036593.1; NM_001043128.2. [E1JI63-2]
DR RefSeq; NP_001163372.1; NM_001169901.1. [E1JI63-1]
DR RefSeq; NP_001261539.1; NM_001274610.1. [E1JI63-1]
DR AlphaFoldDB; E1JI63; -.
DR SMR; E1JI63; -.
DR STRING; 7227.FBpp0290423; -.
DR GlyGen; E1JI63; 4 sites.
DR PaxDb; E1JI63; -.
DR EnsemblMetazoa; FBtr0110885; FBpp0110185; FBgn0035815. [E1JI63-2]
DR EnsemblMetazoa; FBtr0301205; FBpp0290423; FBgn0035815. [E1JI63-1]
DR EnsemblMetazoa; FBtr0334649; FBpp0306711; FBgn0035815. [E1JI63-1]
DR GeneID; 38868; -.
DR KEGG; dme:Dmel_CG7422; -.
DR UCSC; CG7422-RB; d. melanogaster.
DR CTD; 38868; -.
DR FlyBase; FBgn0035815; Snmp2.
DR VEuPathDB; VectorBase:FBgn0035815; -.
DR eggNOG; KOG3776; Eukaryota.
DR InParanoid; E1JI63; -.
DR OMA; IVKSNGC; -.
DR PhylomeDB; E1JI63; -.
DR Reactome; R-DME-114608; Platelet degranulation.
DR Reactome; R-DME-1236973; Cross-presentation of particulate exogenous antigens (phagosomes).
DR Reactome; R-DME-434313; Intracellular metabolism of fatty acids regulates insulin secretion.
DR Reactome; R-DME-6798695; Neutrophil degranulation.
DR BioGRID-ORCS; 38868; 0 hits in 3 CRISPR screens.
DR ChiTaRS; Snmp2; fly.
DR GenomeRNAi; 38868; -.
DR PRO; PR:E1JI63; -.
DR Proteomes; UP000000803; Chromosome 3L.
DR Bgee; FBgn0035815; Expressed in crop (Drosophila) and 12 other tissues.
DR ExpressionAtlas; E1JI63; baseline and differential.
DR Genevisible; E1JI63; DM.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005044; F:scavenger receptor activity; IBA:GO_Central.
DR GO; GO:0071444; P:cellular response to pheromone; ISS:FlyBase.
DR GO; GO:0007608; P:sensory perception of smell; IEA:UniProtKB-KW.
DR InterPro; IPR002159; CD36_fam.
DR PANTHER; PTHR11923; PTHR11923; 1.
DR Pfam; PF01130; CD36; 1.
DR PRINTS; PR01609; CD36FAMILY.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell membrane; Disulfide bond; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..556
FT /note="Sensory neuron membrane protein 2"
FT /id="PRO_0000414928"
FT TOPO_DOM 1..6
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 7..27
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 28..522
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 523..543
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 544..556
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 66
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 274
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 310
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 324
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 320..388
FT /evidence="ECO:0000250|UniProtKB:P26201"
FT DISULFID 349..415
FT /evidence="ECO:0000250|UniProtKB:P26201"
FT VAR_SEQ 140..185
FT /note="Missing (in isoform B)"
FT /evidence="ECO:0000303|PubMed:10731132"
FT /id="VSP_042166"
FT CONFLICT 120
FT /note="V -> A (in Ref. 1; ABW70129)"
FT /evidence="ECO:0000305"
FT CONFLICT 219
FT /note="F -> S (in Ref. 1; ABW70129)"
FT /evidence="ECO:0000305"
FT CONFLICT 516
FT /note="N -> S (in Ref. 1; ABW70129)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 556 AA; 62634 MW; 2D09B0C45BFCAA7F CRC64;
MIHWSLIVSA LGVCVAVLGG YCGWILFPNM VHKKVEQSVV IQDGSEQFKR FVNLPQPLNF
KVYIFNVTNS DRIQQGAIPI VEEIGPYVYK QFRQKKVKHF SRDGSKISYV QNVHFDFDAV
ASAPYTQDDR IVALNMHMNA FLQVFEREIT DIFQGFANRL NSRLNQTPGV RVLKRLMERI
RGKRKSVLQI SENDPGLALL LVHLNANLKA VFNDPRSMFV STSVREYLFD GVRFCINPQG
IAKAICNQIK ESGSKTIREK SDGSLAFSFF GHKNGSGHEV YEVHTGKGDP MRVLEIQKLD
DSHNLQVWLN ASSEGETSVC NQINGTDASA YPPFRQRGDS MYIFSADICR SVQLFYQTDI
QYQGIPGYRY SIGENFINDI GPEHDNECFC VDKLANVIKR KNGCLYAGAL DLTTCLDAPV
ILTLPHMLGA SNEYRKMIRG LKPDAKKHQT FVDVQSLTGT PLQGGKRVQF NMFLKSINRI
GITENLPTVL MPAIWVEEGI QLNGEMVAFF KKKLINTLKT LNIVHWATLC GGIGVAVACL
IYYIYQRGRV VEPPVK
