ID   SNMP2_MANSE             Reviewed;         519 AA.
AC   Q9GPH8;
DT   19-OCT-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   25-MAY-2022, entry version 36.
DE   RecName: Full=Sensory neuron membrane protein 2 {ECO:0000312|EMBL:AAG49365.1};
DE            Short=SNMP2-Msex {ECO:0000303|PubMed:11536197};
OS   Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Bombycoidea;
OC   Sphingidae; Sphinginae; Sphingini; Manduca.
OX   NCBI_TaxID=7130;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:AAG49365.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   TISSUE=Antenna {ECO:0000269|PubMed:11536197};
RX   PubMed=11536197; DOI=10.1002/neu.1065;
RA   Rogers M.E., Krieger J., Vogt R.G.;
RT   "Antennal SNMPs (sensory neuron membrane proteins) of Lepidoptera define a
RT   unique family of invertebrate CD36-like proteins.";
RL   J. Neurobiol. 49:47-61(2001).
CC   -!- FUNCTION: Plays an olfactory role that is not restricted to pheromone
CC       sensitivity. {ECO:0000250|UniProtKB:O02351}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:O02351};
CC       Multi-pass membrane protein {ECO:0000250|UniProtKB:O02351}.
CC   -!- TISSUE SPECIFICITY: Localizes to both male and female antennae but not
CC       the leg, wing, gut, head or thoracic ganglia. Detected throughout the
CC       sensory epithelium, associating with both sex-pheromone sensilla and
CC       plant-volatile sensilla. Differentially expressed among different
CC       sensilla and different neurons within a given sensillum.
CC       {ECO:0000269|PubMed:11536197}.
CC   -!- SIMILARITY: Belongs to the CD36 family. {ECO:0000255}.
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DR   EMBL; AF323588; AAG49365.1; -; mRNA.
DR   AlphaFoldDB; Q9GPH8; -.
DR   SMR; Q9GPH8; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
DR   GO; GO:0007608; P:sensory perception of smell; IEA:UniProtKB-KW.
DR   InterPro; IPR002159; CD36_fam.
DR   PANTHER; PTHR11923; PTHR11923; 1.
DR   Pfam; PF01130; CD36; 1.
DR   PRINTS; PR01609; CD36FAMILY.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; Glycoprotein; Membrane; Olfaction; Receptor;
KW   Sensory transduction; Transmembrane; Transmembrane helix.
FT   CHAIN           1..519
FT                   /note="Sensory neuron membrane protein 2"
FT                   /id="PRO_0000413631"
FT   TOPO_DOM        1..7
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        8..28
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        29..469
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        470..490
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        491..519
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        44
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        67
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        104
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        166
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        229
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        272
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        314
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        268..338
FT                   /evidence="ECO:0000250|UniProtKB:P26201"
FT   DISULFID        299..362
FT                   /evidence="ECO:0000250|UniProtKB:P26201"
FT   DISULFID        340..351
FT                   /evidence="ECO:0000250|UniProtKB:P26201"
SQ   SEQUENCE   519 AA;  58331 MW;  7C914BCF6A00D6DB CRC64;
     MLAKHSKLFF TGSVVFLIVA IVLASWGFPK IISTRIQKSI QLENSSMMYD KWVKLPIPLI
     FKVYFFNVTN AEGINEGERP ILQEIGPYVY KQYRERTVLG YGPNDTIKYM LKKNFVFDPE
     ASNGLTEDDD VTVINFPYMA ALLTIQQMMP SAVAMVNRAL EQFFSNLTDP FMRVKVKDLL
     FDGVFLNCDG DSPALSLVCA KLKADSPPTM RPAEDGVNGY YFSMFSHLNR TETGPYEMVR
     GTEDVFALGN IVSYKEKKSV SAWGDEYCNR INGSDASIFP PIDENNVPER LYTFEPEICR
     SLYASLAGKA TLFNISTYYY EISSSALASK SANPDNKCYC KKDWSASHDG CLLMGVFNLM
     PCQGAPAIAS LPHFYLASEE LLEYFEDGVK PDKEKHNTYV YIDPVTGVVL KGVKRLQFNI
     ELRNMPRVPQ LQAVPTGLFP MLWIEEGAVM TPDLQQELRD AHALLSYAQL ARWIILAAAI
     ILAIIATITV ARSTSLISWP RNSNSVNFII GPMVNDKMR