ID   SNN_BOVIN               Reviewed;          87 AA.
AC   Q17Q87;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2006, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Stannin;
GN   Name=SNN;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Brain cortex;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a role in the toxic effects of organotins. Plays a role
CC       in endosomal maturation. {ECO:0000250|UniProtKB:O75324}.
CC   -!- SUBUNIT: Monomer. {ECO:0000250|UniProtKB:O75324}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane
CC       {ECO:0000250|UniProtKB:O75324}; Single-pass membrane protein
CC       {ECO:0000250|UniProtKB:O75324}.
CC   -!- SIMILARITY: Belongs to the stannin family. {ECO:0000305}.
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DR   EMBL; BC118488; AAI18489.1; -; mRNA.
DR   RefSeq; NP_001107194.1; NM_001113722.1.
DR   RefSeq; XP_010817430.1; XM_010819128.2.
DR   AlphaFoldDB; Q17Q87; -.
DR   BMRB; Q17Q87; -.
DR   SMR; Q17Q87; -.
DR   STRING; 9913.ENSBTAP00000037299; -.
DR   PaxDb; Q17Q87; -.
DR   Ensembl; ENSBTAT00000083767; ENSBTAP00000062234; ENSBTAG00000054404.
DR   GeneID; 615361; -.
DR   KEGG; bta:615361; -.
DR   CTD; 8303; -.
DR   VEuPathDB; HostDB:ENSBTAG00000054404; -.
DR   VGNC; VGNC:35066; SNN.
DR   eggNOG; ENOG502S14Z; Eukaryota.
DR   GeneTree; ENSGT00390000009447; -.
DR   HOGENOM; CLU_2711160_0_0_1; -.
DR   InParanoid; Q17Q87; -.
DR   OMA; FGCWCYL; -.
DR   OrthoDB; 1594644at2759; -.
DR   TreeFam; TF336244; -.
DR   Proteomes; UP000009136; Chromosome 25.
DR   Bgee; ENSBTAG00000054404; Expressed in neutrophil and 106 other tissues.
DR   ExpressionAtlas; Q17Q87; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:Ensembl.
DR   CDD; cd20257; Stannin; 1.
DR   Gene3D; 4.10.280.20; -; 1.
DR   InterPro; IPR015137; SNN_cytoplasm.
DR   InterPro; IPR015136; SNN_linker.
DR   InterPro; IPR015135; SNN_transmemb.
DR   InterPro; IPR038747; Stannin.
DR   InterPro; IPR027435; Stannin_sf.
DR   PANTHER; PTHR28564; PTHR28564; 1.
DR   Pfam; PF09051; SNN_cytoplasm; 1.
DR   Pfam; PF09050; SNN_linker; 1.
DR   Pfam; PF09049; SNN_transmemb; 1.
PE   3: Inferred from homology;
KW   Membrane; Mitochondrion; Mitochondrion outer membrane; Phosphoprotein;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..87
FT                   /note="Stannin"
FT                   /id="PRO_0000282601"
FT   TOPO_DOM        1..10
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        11..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        32..87
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         49
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P61807"
SQ   SEQUENCE   87 AA;  9396 MW;  92D90AEFAACAFC77 CRC64;
     MSIMDHSPTT GVVTVIVILI AIAALGALIL GCWCYLRLQR ISQSEDEESI VGDGETKEPF
     LLVQYSAKGP CVERKAKLTP NGPEVHS