SNN_MOUSE
ID SNN_MOUSE Reviewed; 88 AA.
AC P61807; O88369;
DT 07-JUN-2004, integrated into UniProtKB/Swiss-Prot.
DT 07-JUN-2004, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Stannin;
GN Name=Snn;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9657854; DOI=10.1007/s003359900818;
RA Dejneka N.S., Polavarapu R., Deng X., Martin-Deleon P.A., Billingsley M.L.;
RT "Chromosomal localization and characterization of the stannin (Snn) gene.";
RL Mamm. Genome 9:556-564(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Kidney, and Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-49 AND SER-83, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Embryonic brain;
RX PubMed=15345747; DOI=10.1074/mcp.m400085-mcp200;
RA Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P.;
RT "Phosphoproteomic analysis of the developing mouse brain.";
RL Mol. Cell. Proteomics 3:1093-1101(2004).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-83, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [5]
RP FUNCTION.
RX PubMed=27015288; DOI=10.1371/journal.pbio.1002395;
RA Pueyo J.I., Magny E.G., Sampson C.J., Amin U., Evans I.R., Bishop S.A.,
RA Couso J.P.;
RT "Hemotin, a regulator of phagocytosis encoded by a small ORF and conserved
RT across metazoans.";
RL PLoS Biol. 14:E1002395-E1002395(2016).
CC -!- FUNCTION: Plays a role in the toxic effects of organotins (By
CC similarity). Plays a role in endosomal maturation (PubMed:27015288).
CC {ECO:0000250|UniProtKB:O75324, ECO:0000269|PubMed:27015288}.
CC -!- SUBUNIT: Monomer. {ECO:0000250|UniProtKB:O75324}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250};
CC Single-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the stannin family. {ECO:0000305}.
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DR EMBL; AF030522; AAC28428.1; -; Genomic_DNA.
DR EMBL; BC017685; AAH17685.1; -; mRNA.
DR EMBL; BC063027; AAH63027.1; -; mRNA.
DR CCDS; CCDS37255.1; -.
DR RefSeq; NP_033249.1; NM_009223.3.
DR RefSeq; XP_006521943.1; XM_006521880.1.
DR AlphaFoldDB; P61807; -.
DR BMRB; P61807; -.
DR SMR; P61807; -.
DR IntAct; P61807; 2.
DR MINT; P61807; -.
DR STRING; 10090.ENSMUSP00000086405; -.
DR iPTMnet; P61807; -.
DR PhosphoSitePlus; P61807; -.
DR SwissPalm; P61807; -.
DR PaxDb; P61807; -.
DR PRIDE; P61807; -.
DR ProteomicsDB; 261387; -.
DR Antibodypedia; 2691; 9 antibodies from 8 providers.
DR Ensembl; ENSMUST00000089011; ENSMUSP00000086405; ENSMUSG00000037972.
DR Ensembl; ENSMUST00000228962; ENSMUSP00000154936; ENSMUSG00000037972.
DR GeneID; 20621; -.
DR KEGG; mmu:20621; -.
DR UCSC; uc007yeq.3; mouse.
DR CTD; 8303; -.
DR MGI; MGI:1276549; Snn.
DR VEuPathDB; HostDB:ENSMUSG00000037972; -.
DR eggNOG; ENOG502S14Z; Eukaryota.
DR GeneTree; ENSGT00390000009447; -.
DR HOGENOM; CLU_2711160_0_0_1; -.
DR InParanoid; P61807; -.
DR OMA; FGCWCYL; -.
DR OrthoDB; 1594644at2759; -.
DR PhylomeDB; P61807; -.
DR TreeFam; TF336244; -.
DR BioGRID-ORCS; 20621; 0 hits in 71 CRISPR screens.
DR ChiTaRS; Snn; mouse.
DR PRO; PR:P61807; -.
DR Proteomes; UP000000589; Chromosome 16.
DR RNAct; P61807; protein.
DR Bgee; ENSMUSG00000037972; Expressed in cortical plate and 213 other tissues.
DR ExpressionAtlas; P61807; baseline and differential.
DR Genevisible; P61807; MM.
DR GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR GO; GO:0016021; C:integral component of membrane; ISO:MGI.
DR GO; GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; ISO:MGI.
DR CDD; cd20257; Stannin; 1.
DR Gene3D; 4.10.280.20; -; 1.
DR InterPro; IPR015137; SNN_cytoplasm.
DR InterPro; IPR015136; SNN_linker.
DR InterPro; IPR015135; SNN_transmemb.
DR InterPro; IPR038747; Stannin.
DR InterPro; IPR027435; Stannin_sf.
DR PANTHER; PTHR28564; PTHR28564; 1.
DR Pfam; PF09051; SNN_cytoplasm; 1.
DR Pfam; PF09050; SNN_linker; 1.
DR Pfam; PF09049; SNN_transmemb; 1.
PE 1: Evidence at protein level;
KW Membrane; Mitochondrion; Mitochondrion outer membrane; Phosphoprotein;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..88
FT /note="Stannin"
FT /id="PRO_0000072015"
FT TOPO_DOM 1..10
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000250"
FT TRANSMEM 11..31
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 32..88
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT MOD_RES 49
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:15345747"
FT MOD_RES 83
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:15345747,
FT ECO:0007744|PubMed:21183079"
SQ SEQUENCE 88 AA; 9501 MW; EB8DA73323D816C5 CRC64;
MSIMDHSPTT GVVTVIVILI AIAALGALIL GCWCYLRLQR ISQSEDEESI VGDGETKEPF
LLVQYSAKGP CVERKAKLMT ANSPEVHG
