SNORC_MOUSE
ID SNORC_MOUSE Reviewed; 121 AA.
AC Q9CXL7; Q08EF5;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Protein SNORC {ECO:0000303|PubMed:21624478, ECO:0000305};
DE AltName: Full=Secondary ossification center-associated regulator of chondrocyte maturation protein {ECO:0000303|PubMed:21624478, ECO:0000305};
DE Flags: Precursor;
GN Name=Snorc {ECO:0000303|PubMed:21624478, ECO:0000305};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Head;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP CHARACTERIZATION, TISSUE SPECIFICITY, INDUCTION BY BMP2, DEVELOPMENTAL
RP STAGE, AND SUBCELLULAR LOCATION.
RX PubMed=21624478; DOI=10.1016/j.joca.2011.04.016;
RA Heinonen J., Taipaleenmaeki H., Roering P., Takatalo M., Harkness L.,
RA Sandholm J., Uusitalo-Jaervinen H., Kassem M., Kiviranta I.,
RA Laitala-Leinonen T., Saeaemaenen A.M.;
RT "Snorc is a novel cartilage specific small membrane proteoglycan expressed
RT in differentiating and articular chondrocytes.";
RL Osteoarthritis Cartilage 19:1026-1035(2011).
RN [4]
RP FUNCTION, DISRUPTION PHENOTYPE, TISSUE SPECIFICITY, AND SUBCELLULAR
RP LOCATION.
RX PubMed=28323137; DOI=10.1016/j.joca.2017.03.010;
RA Heinonen J., Zhang F.P., Surmann-Schmitt C., Honkala S., Stock M.,
RA Poutanen M., Saeaemaenen A.M.;
RT "Defects in chondrocyte maturation and secondary ossification in mouse knee
RT joint epiphyses due to Snorc deficiency.";
RL Osteoarthritis Cartilage 25:1132-1142(2017).
CC -!- FUNCTION: Plays a role in the regulation of chondrocyte maturation and
CC postnatal endochondral ossification. May inhibit cell growth
CC stimulation induced by FGF2. {ECO:0000269|PubMed:28323137}.
CC -!- SUBUNIT: Interacts (via the extracellular domain) with FGF2.
CC {ECO:0000269|PubMed:28323137}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305|PubMed:28323137}; Single-
CC pass membrane protein {ECO:0000305}. Cytoplasm
CC {ECO:0000269|PubMed:21624478}. Secreted, extracellular space,
CC extracellular matrix {ECO:0000269|PubMed:21624478,
CC ECO:0000269|PubMed:28323137}. Note=Appears as reticular-like structures
CC throughout the cytoplasm and adjacent to the plasma membrane
CC (PubMed:21624478). In proliferation and hypertrophic chondrocytes,
CC detected intracellulary and in the pericellular extracellular matrix.
CC In primary spongiosa, detected only in the extracellular matrix
CC (PubMed:28323137). {ECO:0000269|PubMed:21624478,
CC ECO:0000269|PubMed:28323137}.
CC -!- TISSUE SPECIFICITY: Expressed only in cartilage, including nasal, knee
CC epiphyseal and rib tissues (PubMed:21624478). In proliferation and
CC hypertrophic chondrocytes, detected intracellulary and in the
CC pericellular extracellular matrix. In primary spongiosa, detected only
CC in the extracellular matrix (PubMed:28323137).
CC {ECO:0000269|PubMed:21624478, ECO:0000269|PubMed:28323137}.
CC -!- DEVELOPMENTAL STAGE: At 16.5 dpc and 18.5 dpc expression is cartilage
CC specific. In tracheal and nasal cartilage, expression is seen
CC throughout all chondrocytes at a similar intensity while in other
CC cartilage tissues undergoing endochondral ossification, intensity is
CC strongest in proliferating and prehypertrophic stages. In knee
CC epiphyseal cartilage, expression is detected from 12.5 dpc onwards,
CC with significant up-regulation at 16.5 dpc and again at postnatal day
CC 5. Expressed at least until 10 months of age.
CC {ECO:0000269|PubMed:21624478}.
CC -!- INDUCTION: In chondrocytes, induced by BMP2.
CC {ECO:0000269|PubMed:21624478}.
CC -!- DISRUPTION PHENOTYPE: Mutants are born with the expected Mendelian
CC frequency and show no differences in fertility, gross morphology or
CC body weight (PubMed:28323137). Secondary ossification centers in knee
CC epiphyses are smaller and growth plate maturation is disturbed, but
CC total bone length is normal. Central proliferative and hypertrophic
CC zones are enlarged with higher extracellular matrix volume and rounded
CC chondrocyte morphology at postnatal days P10 and P22 (PubMed:28323137).
CC {ECO:0000269|PubMed:28323137}.
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DR EMBL; AK014261; BAB29229.1; -; mRNA.
DR EMBL; BC115669; AAI15670.1; -; mRNA.
DR EMBL; BC115670; AAI15671.1; -; mRNA.
DR CCDS; CCDS48305.1; -.
DR RefSeq; NP_082749.1; NM_028473.1.
DR RefSeq; XP_006529958.1; XM_006529895.3.
DR AlphaFoldDB; Q9CXL7; -.
DR STRING; 10090.ENSMUSP00000027476; -.
DR iPTMnet; Q9CXL7; -.
DR PhosphoSitePlus; Q9CXL7; -.
DR PaxDb; Q9CXL7; -.
DR PRIDE; Q9CXL7; -.
DR Antibodypedia; 65848; 5 antibodies from 5 providers.
DR Ensembl; ENSMUST00000027476; ENSMUSP00000027476; ENSMUSG00000026258.
DR GeneID; 73234; -.
DR KEGG; mmu:73234; -.
DR UCSC; uc007bww.2; mouse.
DR CTD; 389084; -.
DR MGI; MGI:1920484; Snorc.
DR VEuPathDB; HostDB:ENSMUSG00000026258; -.
DR eggNOG; ENOG502S8U6; Eukaryota.
DR GeneTree; ENSGT00390000008993; -.
DR HOGENOM; CLU_166240_0_0_1; -.
DR InParanoid; Q9CXL7; -.
DR OMA; ATAFPPY; -.
DR OrthoDB; 1594988at2759; -.
DR PhylomeDB; Q9CXL7; -.
DR TreeFam; TF338619; -.
DR BioGRID-ORCS; 73234; 1 hit in 74 CRISPR screens.
DR PRO; PR:Q9CXL7; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; Q9CXL7; protein.
DR Bgee; ENSMUSG00000026258; Expressed in femorotibial joint and 47 other tissues.
DR ExpressionAtlas; Q9CXL7; baseline and differential.
DR Genevisible; Q9CXL7; MM.
DR GO; GO:0071944; C:cell periphery; IDA:UniProtKB.
DR GO; GO:0062023; C:collagen-containing extracellular matrix; IDA:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0051216; P:cartilage development; IMP:UniProtKB.
DR InterPro; IPR031500; SNORC.
DR PANTHER; PTHR28453; PTHR28453; 1.
DR Pfam; PF15756; DUF4690; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Extracellular matrix; Membrane; Reference proteome; Secreted;
KW Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT CHAIN 25..121
FT /note="Protein SNORC"
FT /id="PRO_0000317642"
FT TOPO_DOM 25..92
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 93..113
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 114..121
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT REGION 26..84
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 48..62
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 25
FT /note="Missing (in Ref. 2; AAI15670)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 121 AA; 12175 MW; E5D09D43EAA199F0 CRC64;
MASCLALRVA LLLISGVLAP AVLTAEGPQE PDPTLWNEPI ELPSGEGPLE STSHNQEFAV
SGPPFPTSAP APEDSTPPAR VDQDGGSLGP GAIAAIVIAA LLATCVVLAL VVVALRKFSA
S
