SNP47_BOVIN
ID SNP47_BOVIN Reviewed; 420 AA.
AC A6QP11;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 21-AUG-2007, sequence version 1.
DT 03-AUG-2022, entry version 66.
DE RecName: Full=Synaptosomal-associated protein 47;
DE Short=SNAP-47;
DE AltName: Full=Synaptosomal-associated 47 kDa protein;
GN Name=SNAP47;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Brain cortex;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP ASSOCIATION WITH THE BLOC-1 COMPLEX, AND INTERACTION WITH BLOC1S6.
RX PubMed=19546860; DOI=10.1038/mp.2009.58;
RA Ghiani C.A., Starcevic M., Rodriguez-Fernandez I.A., Nazarian R.,
RA Cheli V.T., Chan L.N., Malvar J.S., de Vellis J., Sabatti C.,
RA Dell'Angelica E.C.;
RT "The dysbindin-containing complex (BLOC-1) in brain: developmental
RT regulation, interaction with SNARE proteins and role in neurite
RT outgrowth.";
RL Mol. Psychiatry 15:204-215(2010).
CC -!- FUNCTION: May play a role in intracellular membrane fusion.
CC {ECO:0000250}.
CC -!- SUBUNIT: Forms a complex containing SNAP47, VAMP2 and STX1A (By
CC similarity). Associates with the BLOC-1 complex. Interacts with
CC BLOC1S6. {ECO:0000250, ECO:0000269|PubMed:19546860}.
CC -!- SUBCELLULAR LOCATION: Endomembrane system {ECO:0000250}. Cytoplasm,
CC perinuclear region {ECO:0000250}. Note=Appears to be exclusively
CC membrane-bound. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SVAP1 family. {ECO:0000305}.
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DR EMBL; BC149093; AAI49094.1; -; mRNA.
DR RefSeq; NP_001095790.1; NM_001102320.1.
DR AlphaFoldDB; A6QP11; -.
DR SMR; A6QP11; -.
DR STRING; 9913.ENSBTAP00000005482; -.
DR PaxDb; A6QP11; -.
DR PRIDE; A6QP11; -.
DR GeneID; 618546; -.
DR KEGG; bta:618546; -.
DR CTD; 116841; -.
DR eggNOG; KOG3065; Eukaryota.
DR InParanoid; A6QP11; -.
DR OrthoDB; 662135at2759; -.
DR Proteomes; UP000009136; Unplaced.
DR GO; GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR Gene3D; 2.30.29.30; -; 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR000727; T_SNARE_dom.
DR SMART; SM00397; t_SNARE; 1.
DR PROSITE; PS50192; T_SNARE; 2.
PE 1: Evidence at protein level;
KW Coiled coil; Cytoplasm; Membrane; Reference proteome; Repeat.
FT CHAIN 1..420
FT /note="Synaptosomal-associated protein 47"
FT /id="PRO_0000307150"
FT DOMAIN 110..172
FT /note="t-SNARE coiled-coil homology 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00202"
FT DOMAIN 357..419
FT /note="t-SNARE coiled-coil homology 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00202"
FT REGION 338..357
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 420 AA; 47359 MW; 55F448AE31B17939 CRC64;
MSGDTCVQTW PCSYYLELEK RWVPGRLSLT SLSLKFMTDK TRETLVSFPL SSIIEIKKEA
SHFIFSSITI LERDHSKHWF SSLQPSRNAV FSVIEHFWRE LLLSESGAAA EAASSSMTKG
KELTCLMACT QKRLEDTARV LHHQGEQLDG ISRGLDKMES DLDVADRLLT ELESPSWWPF
SSKLWKTPSE TKPKWDASMA DSKAFGKEGI VIQVPAVISQ RTESHVKPGR LTVLVSGLEI
YNSDSLLMHR FEREDVDDIK VHTPYEISIC QRFIGKPDIS YRLISAKMPE VIPILEVQFS
KKIELLEVAM MLGSTRTSSL AEKGYSVWHA ASGLMDQATH CEPSSGSQEG RPLQLQTSEP
VISEEDTQEL GQILRKLKGL ALDTETELER QDEALDGITE AVDRATLTID KHNRRMKKLT
