SNP47_HUMAN
ID SNP47_HUMAN Reviewed; 464 AA.
AC Q5SQN1; B6EDE0; Q5HYB5; Q5TBZ3; Q8N558; Q8TB31; Q8TCW8; Q8WV46; Q96CQ3;
AC Q96FE1; Q96I66; Q96NU3; Q9BT10; Q9BVB2;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 26-MAY-2009, sequence version 3.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Synaptosomal-associated protein 47;
DE Short=SNAP-47;
DE AltName: Full=Epididymis luminal protein 170;
DE AltName: Full=Synaptosomal-associated 47 kDa protein;
GN Name=SNAP47; Synonyms=C1orf142, HEL170, SVAP1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND VARIANT MET-154.
RA Yang J., Qiu Y.;
RT "Homo sapiens GRASP protein.";
RL Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC TISSUE=Colon endothelium;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4), AND VARIANTS
RP ARG-119; MET-154 AND CYS-381.
RC TISSUE=Cervix, Kidney, Lung, Muscle, Ovary, Pancreas, and Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 10-464 (ISOFORM 2), AND VARIANT
RP CYS-381.
RC TISSUE=Astrocyte;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 30-464 (ISOFORM 1).
RA Li J., Wang H.;
RL Submitted (SEP-2008) to the EMBL/GenBank/DDBJ databases.
RN [8]
RP ASSOCIATION WITH THE BLOC-1 COMPLEX, AND INTERACTION WITH BLOC1S6.
RX PubMed=19546860; DOI=10.1038/mp.2009.58;
RA Ghiani C.A., Starcevic M., Rodriguez-Fernandez I.A., Nazarian R.,
RA Cheli V.T., Chan L.N., Malvar J.S., de Vellis J., Sabatti C.,
RA Dell'Angelica E.C.;
RT "The dysbindin-containing complex (BLOC-1) in brain: developmental
RT regulation, interaction with SNARE proteins and role in neurite
RT outgrowth.";
RL Mol. Psychiatry 15:204-215(2010).
CC -!- FUNCTION: Plays a role in intracellular membrane fusion. {ECO:0000250}.
CC -!- SUBUNIT: Forms a complex containing SNAP47, VAMP2 and STX1A (By
CC similarity). Associates with the BLOC-1 complex. Interacts with
CC BLOC1S6. {ECO:0000250, ECO:0000269|PubMed:19546860}.
CC -!- INTERACTION:
CC Q5SQN1; P55056: APOC4; NbExp=3; IntAct=EBI-10244848, EBI-18302142;
CC Q5SQN1; P41181: AQP2; NbExp=3; IntAct=EBI-10244848, EBI-12701138;
CC Q5SQN1; Q8IYX8-2: CEP57L1; NbExp=3; IntAct=EBI-10244848, EBI-10181988;
CC Q5SQN1; Q9Y624: F11R; NbExp=3; IntAct=EBI-10244848, EBI-742600;
CC Q5SQN1; Q8IZU0: FAM9B; NbExp=3; IntAct=EBI-10244848, EBI-10175124;
CC Q5SQN1; Q969F0: FATE1; NbExp=3; IntAct=EBI-10244848, EBI-743099;
CC Q5SQN1; Q08379: GOLGA2; NbExp=3; IntAct=EBI-10244848, EBI-618309;
CC Q5SQN1; Q8N6L0: KASH5; NbExp=3; IntAct=EBI-10244848, EBI-749265;
CC Q5SQN1; Q6P597: KLC3; NbExp=3; IntAct=EBI-10244848, EBI-1643885;
CC Q5SQN1; Q9H400: LIME1; NbExp=3; IntAct=EBI-10244848, EBI-2830566;
CC Q5SQN1; Q9HCJ2: LRRC4C; NbExp=3; IntAct=EBI-10244848, EBI-3925442;
CC Q5SQN1; P43360: MAGEA6; NbExp=3; IntAct=EBI-10244848, EBI-1045155;
CC Q5SQN1; O14880: MGST3; NbExp=3; IntAct=EBI-10244848, EBI-724754;
CC Q5SQN1; Q9UJV3-2: MID2; NbExp=3; IntAct=EBI-10244848, EBI-10172526;
CC Q5SQN1; P15151: PVR; NbExp=3; IntAct=EBI-10244848, EBI-3919694;
CC Q5SQN1; Q96K19-5: RNF170; NbExp=3; IntAct=EBI-10244848, EBI-12055631;
CC Q5SQN1; Q9NR31: SAR1A; NbExp=3; IntAct=EBI-10244848, EBI-3920694;
CC Q5SQN1; Q96R06: SPAG5; NbExp=3; IntAct=EBI-10244848, EBI-413317;
CC Q5SQN1; Q86Y82: STX12; NbExp=2; IntAct=EBI-10244848, EBI-2691717;
CC Q5SQN1; Q16623: STX1A; NbExp=3; IntAct=EBI-10244848, EBI-712466;
CC Q5SQN1; P61266: STX1B; NbExp=3; IntAct=EBI-10244848, EBI-9071709;
CC Q5SQN1; Q12846: STX4; NbExp=3; IntAct=EBI-10244848, EBI-744942;
CC Q5SQN1; Q8IWR1: TRIM59; NbExp=3; IntAct=EBI-10244848, EBI-10262539;
CC Q5SQN1; O75379: VAMP4; NbExp=2; IntAct=EBI-10244848, EBI-744953;
CC Q5SQN1; P51809: VAMP7; NbExp=4; IntAct=EBI-10244848, EBI-1052205;
CC Q5SQN1; PRO_0000037316 [P0C6X7]: rep; Xeno; NbExp=2; IntAct=EBI-10244848, EBI-25475825;
CC Q5SQN1; P32851: Stx1a; Xeno; NbExp=3; IntAct=EBI-10244848, EBI-539720;
CC -!- SUBCELLULAR LOCATION: Endomembrane system {ECO:0000250}. Cytoplasm,
CC perinuclear region {ECO:0000250}. Note=Appears to be exclusively
CC membrane-bound. {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q5SQN1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5SQN1-2; Sequence=VSP_028614;
CC Name=3;
CC IsoId=Q5SQN1-3; Sequence=VSP_028613, VSP_028614;
CC Name=4;
CC IsoId=Q5SQN1-4; Sequence=VSP_028613;
CC -!- SIMILARITY: Belongs to the SVAP1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB70779.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AY090635; AAM09082.1; -; mRNA.
DR EMBL; BX648570; CAI45994.1; -; mRNA.
DR EMBL; AL136378; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL731702; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471098; EAW69817.1; -; Genomic_DNA.
DR EMBL; BC001332; AAH01332.1; -; mRNA.
DR EMBL; BC004418; AAH04418.1; -; mRNA.
DR EMBL; BC007786; AAH07786.2; -; mRNA.
DR EMBL; BC011145; AAH11145.1; -; mRNA.
DR EMBL; BC014059; AAH14059.2; -; mRNA.
DR EMBL; BC018760; AAH18760.2; -; mRNA.
DR EMBL; BC025231; AAH25231.1; -; mRNA.
DR EMBL; BC032775; AAH32775.1; -; mRNA.
DR EMBL; AK054633; BAB70779.1; ALT_INIT; mRNA.
DR EMBL; FJ236305; ACI45237.1; -; mRNA.
DR RefSeq; NP_001310864.1; NM_001323935.1. [Q5SQN1-2]
DR RefSeq; NP_444280.2; NM_053052.3.
DR RefSeq; XP_016855720.1; XM_017000231.1. [Q5SQN1-1]
DR RefSeq; XP_016855721.1; XM_017000232.1. [Q5SQN1-1]
DR AlphaFoldDB; Q5SQN1; -.
DR SMR; Q5SQN1; -.
DR BioGRID; 125534; 192.
DR IntAct; Q5SQN1; 49.
DR MINT; Q5SQN1; -.
DR STRING; 9606.ENSP00000314157; -.
DR GlyGen; Q5SQN1; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q5SQN1; -.
DR PhosphoSitePlus; Q5SQN1; -.
DR BioMuta; SNAP47; -.
DR DMDM; 238054367; -.
DR EPD; Q5SQN1; -.
DR jPOST; Q5SQN1; -.
DR MassIVE; Q5SQN1; -.
DR MaxQB; Q5SQN1; -.
DR PaxDb; Q5SQN1; -.
DR PeptideAtlas; Q5SQN1; -.
DR PRIDE; Q5SQN1; -.
DR ProteomicsDB; 63811; -. [Q5SQN1-1]
DR ProteomicsDB; 63812; -. [Q5SQN1-2]
DR ProteomicsDB; 63813; -. [Q5SQN1-3]
DR ProteomicsDB; 63814; -. [Q5SQN1-4]
DR Antibodypedia; 34657; 45 antibodies from 17 providers.
DR DNASU; 116841; -.
DR Ensembl; ENST00000366760.5; ENSP00000355722.1; ENSG00000143740.15. [Q5SQN1-4]
DR Ensembl; ENST00000418653.6; ENSP00000402730.2; ENSG00000143740.15. [Q5SQN1-3]
DR Ensembl; ENST00000679561.1; ENSP00000504959.1; ENSG00000143740.15. [Q5SQN1-4]
DR Ensembl; ENST00000680695.1; ENSP00000506091.1; ENSG00000143740.15. [Q5SQN1-4]
DR Ensembl; ENST00000681929.1; ENSP00000505648.1; ENSG00000143740.15. [Q5SQN1-4]
DR GeneID; 116841; -.
DR KEGG; hsa:116841; -.
DR UCSC; uc001hra.3; human. [Q5SQN1-1]
DR CTD; 116841; -.
DR DisGeNET; 116841; -.
DR GeneCards; SNAP47; -.
DR HGNC; HGNC:30669; SNAP47.
DR HPA; ENSG00000143740; Low tissue specificity.
DR MIM; 619659; gene.
DR neXtProt; NX_Q5SQN1; -.
DR OpenTargets; ENSG00000143740; -.
DR PharmGKB; PA164725983; -.
DR VEuPathDB; HostDB:ENSG00000143740; -.
DR eggNOG; KOG3065; Eukaryota.
DR GeneTree; ENSGT00950000182843; -.
DR HOGENOM; CLU_1102480_0_0_1; -.
DR InParanoid; Q5SQN1; -.
DR OMA; FDNMMQG; -.
DR OrthoDB; 662135at2759; -.
DR PhylomeDB; Q5SQN1; -.
DR TreeFam; TF331066; -.
DR PathwayCommons; Q5SQN1; -.
DR SignaLink; Q5SQN1; -.
DR BioGRID-ORCS; 116841; 15 hits in 1089 CRISPR screens.
DR ChiTaRS; SNAP47; human.
DR GenomeRNAi; 116841; -.
DR Pharos; Q5SQN1; Tdark.
DR PRO; PR:Q5SQN1; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q5SQN1; protein.
DR Bgee; ENSG00000143740; Expressed in pancreatic ductal cell and 176 other tissues.
DR ExpressionAtlas; Q5SQN1; baseline and differential.
DR Genevisible; Q5SQN1; HS.
DR GO; GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0098793; C:presynapse; IEA:GOC.
DR GO; GO:0031201; C:SNARE complex; IBA:GO_Central.
DR GO; GO:0005484; F:SNAP receptor activity; IBA:GO_Central.
DR GO; GO:0019905; F:syntaxin binding; IBA:GO_Central.
DR GO; GO:0006887; P:exocytosis; IBA:GO_Central.
DR GO; GO:0031629; P:synaptic vesicle fusion to presynaptic active zone membrane; IBA:GO_Central.
DR GO; GO:0016082; P:synaptic vesicle priming; IBA:GO_Central.
DR GO; GO:0006906; P:vesicle fusion; IBA:GO_Central.
DR Gene3D; 2.30.29.30; -; 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR000727; T_SNARE_dom.
DR PROSITE; PS50192; T_SNARE; 2.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Cytoplasm; Membrane; Reference proteome;
KW Repeat.
FT CHAIN 1..464
FT /note="Synaptosomal-associated protein 47"
FT /id="PRO_0000307151"
FT DOMAIN 154..216
FT /note="t-SNARE coiled-coil homology 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00202"
FT DOMAIN 401..463
FT /note="t-SNARE coiled-coil homology 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00202"
FT REGION 20..42
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..242
FT /note="Missing (in isoform 3 and isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:17974005"
FT /id="VSP_028613"
FT VAR_SEQ 417..464
FT /note="ILRRMKGLALEAESELERQDEALDGVAAAVDRATLTIDKHNRRMKRLT ->
FT GFRPMSLSTQTVLVMLCSESAGALWRQRLS (in isoform 2 and isoform
FT 3)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:17974005"
FT /id="VSP_028614"
FT VARIANT 48
FT /note="R -> G (in dbSNP:rs2236359)"
FT /id="VAR_035367"
FT VARIANT 119
FT /note="G -> R (in dbSNP:rs12239037)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_035368"
FT VARIANT 154
FT /note="V -> M (in dbSNP:rs2236358)"
FT /evidence="ECO:0000269|PubMed:15489334, ECO:0000269|Ref.1"
FT /id="VAR_035369"
FT VARIANT 381
FT /note="R -> C (in dbSNP:rs17851681)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:15489334"
FT /id="VAR_035370"
FT CONFLICT 84..86
FT /note="DST -> TRP (in Ref. 5; AAH01332)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 464 AA; 52562 MW; FC4061061B0042ED CRC64;
MRAARRGLHC AGAERPRRRG RLWDSSGVPQ RQKRPGPWRT QTQEQMSRDV CIHTWPCTYY
LEPKRRWVTG QLSLTSLSLR FMTDSTGEIL VSFPLSSIVE IKKEASHFIF SSITILEKGH
AKHWFSSLRP SRNVVFSIIE HFWRELLLSQ PGAVADASVP RTRGEELTGL MAGSQKRLED
TARVLHHQGQ QLDSVMRGLD KMESDLEVAD RLLTELESPA WWPFSSKLWK TPPETKPRED
VSMTSCEPFG KEGILIKIPA VISHRTESHV KPGRLTVLVS GLEIHDSSSL LMHRFEREDV
DDIKVHSPYE ISIRQRFIGK PDMAYRLISA KMPEVIPILE VQFSKKMELL EDALVLRSAR
TSSPAEKSCS VWHAASGLMG RTLHREPPAG DQEGTALHLQ TSLPALSEAD TQELTQILRR
MKGLALEAES ELERQDEALD GVAAAVDRAT LTIDKHNRRM KRLT
