ID   SNP47_RAT               Reviewed;         419 AA.
AC   Q6P6S0;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=Synaptosomal-associated protein 47;
DE            Short=SNAP-47;
DE   AltName: Full=Synaptosomal-associated 47 kDa protein;
GN   Name=Snap47;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Prostate;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May play a role in intracellular membrane fusion.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Associates with the BLOC-1 complex. Interacts with BLOC1S6.
CC       Forms a complex containing SNAP47, VAMP2 and STX1A (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endomembrane system {ECO:0000250}. Cytoplasm,
CC       perinuclear region {ECO:0000250}. Note=Appears to be exclusively
CC       membrane-bound. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SVAP1 family. {ECO:0000305}.
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DR   EMBL; BC062056; AAH62056.1; -; mRNA.
DR   RefSeq; NP_955421.1; NM_199389.1.
DR   RefSeq; XP_006246550.1; XM_006246488.3.
DR   AlphaFoldDB; Q6P6S0; -.
DR   SMR; Q6P6S0; -.
DR   CORUM; Q6P6S0; -.
DR   STRING; 10116.ENSRNOP00000029215; -.
DR   iPTMnet; Q6P6S0; -.
DR   PhosphoSitePlus; Q6P6S0; -.
DR   PaxDb; Q6P6S0; -.
DR   PRIDE; Q6P6S0; -.
DR   Ensembl; ENSRNOT00000119360; ENSRNOP00000076626; ENSRNOG00000022472.
DR   GeneID; 303183; -.
DR   KEGG; rno:303183; -.
DR   UCSC; RGD:735194; rat.
DR   CTD; 116841; -.
DR   RGD; 735194; Snap47.
DR   eggNOG; KOG3065; Eukaryota.
DR   GeneTree; ENSGT00950000182843; -.
DR   HOGENOM; CLU_029855_0_0_1; -.
DR   InParanoid; Q6P6S0; -.
DR   OMA; FDNMMQG; -.
DR   OrthoDB; 662135at2759; -.
DR   PhylomeDB; Q6P6S0; -.
DR   TreeFam; TF331066; -.
DR   PRO; PR:Q6P6S0; -.
DR   Proteomes; UP000002494; Chromosome 10.
DR   Bgee; ENSRNOG00000022472; Expressed in skeletal muscle tissue and 18 other tissues.
DR   GO; GO:0032279; C:asymmetric synapse; IDA:SynGO.
DR   GO; GO:0030425; C:dendrite; ISO:RGD.
DR   GO; GO:0098978; C:glutamatergic synapse; ISO:RGD.
DR   GO; GO:0098686; C:hippocampal mossy fiber to CA3 synapse; IDA:SynGO.
DR   GO; GO:0016020; C:membrane; ISO:RGD.
DR   GO; GO:0043025; C:neuronal cell body; ISO:RGD.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0014069; C:postsynaptic density; IDA:SynGO.
DR   GO; GO:0031201; C:SNARE complex; IBA:GO_Central.
DR   GO; GO:0030672; C:synaptic vesicle membrane; ISO:RGD.
DR   GO; GO:0005484; F:SNAP receptor activity; IBA:GO_Central.
DR   GO; GO:0019905; F:syntaxin binding; IBA:GO_Central.
DR   GO; GO:0098967; P:exocytic insertion of neurotransmitter receptor to postsynaptic membrane; ISO:RGD.
DR   GO; GO:0006887; P:exocytosis; IBA:GO_Central.
DR   GO; GO:0060291; P:long-term synaptic potentiation; ISO:RGD.
DR   GO; GO:0031629; P:synaptic vesicle fusion to presynaptic active zone membrane; IBA:GO_Central.
DR   GO; GO:0016082; P:synaptic vesicle priming; IBA:GO_Central.
DR   GO; GO:0006906; P:vesicle fusion; IBA:GO_Central.
DR   GO; GO:0099003; P:vesicle-mediated transport in synapse; ISO:RGD.
DR   Gene3D; 2.30.29.30; -; 1.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR000727; T_SNARE_dom.
DR   PROSITE; PS50192; T_SNARE; 2.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Membrane; Reference proteome; Repeat.
FT   CHAIN           1..419
FT                   /note="Synaptosomal-associated protein 47"
FT                   /id="PRO_0000307153"
FT   DOMAIN          109..171
FT                   /note="t-SNARE coiled-coil homology 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00202"
FT   DOMAIN          356..418
FT                   /note="t-SNARE coiled-coil homology 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00202"
SQ   SEQUENCE   419 AA;  47042 MW;  4B7D9E4E9A448D0F CRC64;
     MSSDVRVHTW PCSYYLDLEK QWLPGKLTLT PRSLKFSVDK AEEVLVGLPL SSITEIRKET
     SLFIFSAITV LEKGQAKHWF SSLRPSRNVV FNIIEHFWRE LLLSQPGTAA NPTSPMTRGQ
     ELMGLMASSQ RRMEDTAKVL HHQGEQLDSV MRGLEKMESD LDVADRLLTE LETPSWWPFS
     AKFWKTPVEA KPRDSVSVAP CEPFGKEGVV IRVPAVVSQR TESHSKPGKL TVLVSGLEIH
     DSSSLLLHRF EKEDVDDIKV HSPYEVSIRQ RFIGKPDVAY RLISAKMPEV IPILEVQFSK
     KIELLEDALV LRSRGRASPA EGGCSIRHAA SRLMGCTTHQ ELPTGGQEGQ QSQLQKDWPL
     LSEGEAQELT QILSKLKGLA LDTEAELERQ DAALDGITVA VDRATLTVDK HNRRMRKLL