SNPC1_HUMAN
ID SNPC1_HUMAN Reviewed; 368 AA.
AC Q16533;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 165.
DE RecName: Full=snRNA-activating protein complex subunit 1;
DE Short=SNAPc subunit 1;
DE AltName: Full=Proximal sequence element-binding transcription factor subunit gamma;
DE Short=PSE-binding factor subunit gamma;
DE Short=PTF subunit gamma;
DE AltName: Full=Small nuclear RNA-activating complex polypeptide 1;
DE AltName: Full=snRNA-activating protein complex 43 kDa subunit;
DE Short=SNAPc 43 kDa subunit;
GN Name=SNAPC1; Synonyms=SNAP43;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND PARTIAL PROTEIN SEQUENCE.
RX PubMed=7715707; DOI=10.1038/374653a0;
RA Henry R.W., Sadowski C.L., Kobayashi R., Hernandez N.;
RT "A TBP-TAF complex required for transcription of human snRNA genes by RNA
RT polymerase II and III.";
RL Nature 374:653-656(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=8524284; DOI=10.1128/mcb.16.1.1;
RA Yoon J.B., Roeder R.G.;
RT "Cloning of two proximal sequence element-binding transcription factor
RT subunits (gamma and delta) that are required for transcription of small
RT nuclear RNA genes by RNA polymerases II and III and interact with the TATA-
RT binding protein.";
RL Mol. Cell. Biol. 16:1-9(1996).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney, and Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP INTERACTION WITH SNAPC3 AND SNAPC4.
RX PubMed=11056176; DOI=10.1074/jbc.m009301200;
RA Ma B., Hernandez N.;
RT "A map of protein-protein contacts within the small nuclear RNA-activating
RT protein complex SNAPc.";
RL J. Biol. Chem. 276:5027-5035(2001).
RN [5]
RP FUNCTION, AND INTERACTION WITH SNAPC3 AND TBP.
RX PubMed=12621023; DOI=10.1074/jbc.m204247200;
RA Hinkley C.S., Hirsch H.A., Gu L., LaMere B., Henry R.W.;
RT "The small nuclear RNA-activating protein 190 Myb DNA binding domain
RT stimulates TATA box-binding protein-TATA box recognition.";
RL J. Biol. Chem. 278:18649-18657(2003).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-290, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-289 AND SER-290, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T.,
RA Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.;
RT "System-wide temporal characterization of the proteome and phosphoproteome
RT of human embryonic stem cell differentiation.";
RL Sci. Signal. 4:RS3-RS3(2011).
CC -!- FUNCTION: Part of the SNAPc complex required for the transcription of
CC both RNA polymerase II and III small-nuclear RNA genes. Binds to the
CC proximal sequence element (PSE), a non-TATA-box basal promoter element
CC common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA
CC TATA box. {ECO:0000269|PubMed:12621023}.
CC -!- SUBUNIT: Part of the SNAPc complex composed of 5 subunits: SNAPC1,
CC SNAPC2, SNAPC3, SNAPC4 and SNAPC5. SNAPC1 interacts with SNAPC3, SNAPC4
CC and TBP. {ECO:0000269|PubMed:11056176, ECO:0000269|PubMed:12621023}.
CC -!- INTERACTION:
CC Q16533; Q16204: CCDC6; NbExp=3; IntAct=EBI-11915024, EBI-1045350;
CC Q16533; Q8IYI6: EXOC8; NbExp=3; IntAct=EBI-11915024, EBI-742102;
CC Q16533; O14929: HAT1; NbExp=3; IntAct=EBI-11915024, EBI-2339359;
CC Q16533; O75031: HSF2BP; NbExp=3; IntAct=EBI-11915024, EBI-7116203;
CC Q16533; Q92966: SNAPC3; NbExp=4; IntAct=EBI-11915024, EBI-1760638;
CC -!- SUBCELLULAR LOCATION: Nucleus.
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DR EMBL; Z47542; CAA87590.1; -; mRNA.
DR EMBL; U44754; AAC50358.1; -; mRNA.
DR EMBL; BC014984; AAH14984.1; -; mRNA.
DR EMBL; BC019038; AAH19038.1; -; mRNA.
DR CCDS; CCDS9755.1; -.
DR PIR; JC6081; JC6081.
DR RefSeq; NP_003073.1; NM_003082.3.
DR AlphaFoldDB; Q16533; -.
DR BioGRID; 112501; 110.
DR CORUM; Q16533; -.
DR DIP; DIP-504N; -.
DR IntAct; Q16533; 17.
DR STRING; 9606.ENSP00000216294; -.
DR iPTMnet; Q16533; -.
DR PhosphoSitePlus; Q16533; -.
DR BioMuta; SNAPC1; -.
DR DMDM; 8134716; -.
DR EPD; Q16533; -.
DR jPOST; Q16533; -.
DR MassIVE; Q16533; -.
DR MaxQB; Q16533; -.
DR PaxDb; Q16533; -.
DR PeptideAtlas; Q16533; -.
DR PRIDE; Q16533; -.
DR ProteomicsDB; 60896; -.
DR Antibodypedia; 11585; 174 antibodies from 22 providers.
DR DNASU; 6617; -.
DR Ensembl; ENST00000216294.5; ENSP00000216294.4; ENSG00000023608.5.
DR GeneID; 6617; -.
DR KEGG; hsa:6617; -.
DR MANE-Select; ENST00000216294.5; ENSP00000216294.4; NM_003082.4; NP_003073.1.
DR UCSC; uc001xft.3; human.
DR CTD; 6617; -.
DR DisGeNET; 6617; -.
DR GeneCards; SNAPC1; -.
DR HGNC; HGNC:11134; SNAPC1.
DR HPA; ENSG00000023608; Low tissue specificity.
DR MIM; 600591; gene.
DR neXtProt; NX_Q16533; -.
DR OpenTargets; ENSG00000023608; -.
DR PharmGKB; PA35982; -.
DR VEuPathDB; HostDB:ENSG00000023608; -.
DR eggNOG; KOG4746; Eukaryota.
DR GeneTree; ENSGT00390000018691; -.
DR HOGENOM; CLU_067254_0_0_1; -.
DR InParanoid; Q16533; -.
DR OMA; LALAWQY; -.
DR OrthoDB; 1269640at2759; -.
DR PhylomeDB; Q16533; -.
DR TreeFam; TF324445; -.
DR PathwayCommons; Q16533; -.
DR Reactome; R-HSA-6807505; RNA polymerase II transcribes snRNA genes.
DR Reactome; R-HSA-749476; RNA Polymerase III Abortive And Retractive Initiation.
DR Reactome; R-HSA-76071; RNA Polymerase III Transcription Initiation From Type 3 Promoter.
DR SignaLink; Q16533; -.
DR BioGRID-ORCS; 6617; 722 hits in 1073 CRISPR screens.
DR ChiTaRS; SNAPC1; human.
DR GeneWiki; SNAPC1; -.
DR GenomeRNAi; 6617; -.
DR Pharos; Q16533; Tbio.
DR PRO; PR:Q16533; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; Q16533; protein.
DR Bgee; ENSG00000023608; Expressed in cartilage tissue and 191 other tissues.
DR Genevisible; Q16533; HS.
DR GO; GO:0005730; C:nucleolus; IDA:HPA.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0019185; C:snRNA-activating protein complex; IBA:GO_Central.
DR GO; GO:0016251; F:RNA polymerase II general transcription initiation factor activity; TAS:ARUK-UCL.
DR GO; GO:0000995; F:RNA polymerase III general transcription initiation factor activity; TAS:ARUK-UCL.
DR GO; GO:0043565; F:sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0042795; P:snRNA transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0042796; P:snRNA transcription by RNA polymerase III; IBA:GO_Central.
DR InterPro; IPR019188; SNAPC1.
DR PANTHER; PTHR15131; PTHR15131; 1.
DR Pfam; PF09808; SNAPC1; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; DNA-binding; Nucleus; Phosphoprotein;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..368
FT /note="snRNA-activating protein complex subunit 1"
FT /id="PRO_0000072017"
FT REGION 1..168
FT /note="SNAPC3-binding"
FT REGION 164..268
FT /note="SNAPC4-binding"
FT REGION 224..257
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 275..368
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 289
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21406692"
FT MOD_RES 290
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648,
FT ECO:0007744|PubMed:21406692"
SQ SEQUENCE 368 AA; 42994 MW; 324E89CF8B540C32 CRC64;
MGTPPGLQTD CEALLSRFQE TDSVRFEDFT ELWRNMKFGT IFCGRMRNLE KNMFTKEALA
LAWRYFLPPY TFQIRVGALY LLYGLYNTQL CQPKQKIRVA LKDWDEVLKF QQDLVNAQHF
DAAYIFRKLR LDRAFHFTAM PKLLSYRMKK KIHRAEVTEE FKDPSDRVMK LITSDVLEEM
LNVHDHYQNM KHVISVDKSK PDKALSLIKD DFFDNIKNIV LEHQQWHKDR KNPSLKSKTN
DGEEKMEGNS QETERCERAE SLAKIKSKAF SVVIQASKSR RHRQVKLDSS DSDSASGQGQ
VKATRKKEKK ERLKPAGRKM SLRNKGNVQN IHKEDKPLSL SMPVITEEEE NESLSGTEFT
ASKKRRKH
