SNPC1_MACFA
ID SNPC1_MACFA Reviewed; 367 AA.
AC Q4R6W9;
DT 25-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2005, sequence version 1.
DT 03-AUG-2022, entry version 55.
DE RecName: Full=snRNA-activating protein complex subunit 1;
DE Short=SNAPc subunit 1;
DE AltName: Full=Small nuclear RNA-activating complex polypeptide 1;
DE AltName: Full=snRNA-activating protein complex 43 kDa subunit;
DE Short=SNAPc 43 kDa subunit;
GN Name=SNAPC1; ORFNames=QtsA-16981;
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RG International consortium for macaque cDNA sequencing and analysis;
RT "DNA sequences of macaque genes expressed in brain or testis and its
RT evolutionary implications.";
RL Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Part of the SNAPc complex required for the transcription of
CC both RNA polymerase II and III small-nuclear RNA genes. Binds to the
CC proximal sequence element (PSE), a non-TATA-box basal promoter element
CC common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA
CC TATA box (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Part of the SNAPc complex composed of 5 subunits: SNAPC1,
CC SNAPC2, SNAPC3, SNAPC4 and SNAPC5. SNAPC1 interacts with SNAPC3, SNAPC4
CC and TBP (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
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DR EMBL; AB169061; BAE01155.1; -; mRNA.
DR RefSeq; NP_001272039.1; NM_001285110.1.
DR AlphaFoldDB; Q4R6W9; -.
DR STRING; 9541.XP_005561499.1; -.
DR PRIDE; Q4R6W9; -.
DR Ensembl; ENSMFAT00000097964; ENSMFAP00000054137; ENSMFAG00000043540.
DR GeneID; 101866969; -.
DR CTD; 6617; -.
DR VEuPathDB; HostDB:ENSMFAG00000043540; -.
DR eggNOG; KOG4746; Eukaryota.
DR GeneTree; ENSGT00390000018691; -.
DR OMA; LALAWQY; -.
DR OrthoDB; 1269640at2759; -.
DR Proteomes; UP000233100; Chromosome 7.
DR Bgee; ENSMFAG00000043540; Expressed in pituitary gland and 13 other tissues.
DR GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR InterPro; IPR019188; SNAPC1.
DR PANTHER; PTHR15131; PTHR15131; 1.
DR Pfam; PF09808; SNAPC1; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Nucleus; Phosphoprotein; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..367
FT /note="snRNA-activating protein complex subunit 1"
FT /id="PRO_0000072018"
FT REGION 1..168
FT /note="SNAPC3-binding"
FT /evidence="ECO:0000250"
FT REGION 164..268
FT /note="SNAPC4-binding"
FT /evidence="ECO:0000250"
FT REGION 228..254
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 278..367
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 289
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q16533"
FT MOD_RES 290
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q16533"
SQ SEQUENCE 367 AA; 42874 MW; 1F5334F8204B2BA1 CRC64;
MGTPPGLQTD CEALLSRFQE TDSVRFEAFT ELWRNMKFGT IFCGRMRNLE KNMFTKEALA
LAWRYFLPPY TFQIRVGALY LLYGLYNTQL CQPKQKIRVA LKDWDEVLKF QQDLVNAQHF
DAAYIFRKLR LDRAFHFTAM PKLLSYRMKK KIHRAEVTEE FKDPSDRVMK LITSDVLEEM
LNVHDHYQNM KRVISVDKSK PDKALSLIKD DFFDNIKNIV LEHQQWHKDR KNPSLKSKIN
DGEEKMEGNS QETERCERAE SLAKIKSKAF SVVIQASKSR RHRQVKLDSS DCDSASGQGQ
VKATRKKEKK ERLKPAGRKM SFRNKGNVQN IHKEDKPLSL SMPVITEEEN ESLSGTEFTA
SKKKRKH
