SNPC1_MOUSE
ID SNPC1_MOUSE Reviewed; 389 AA.
AC Q8K0S9;
DT 25-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=snRNA-activating protein complex subunit 1;
DE Short=SNAPc subunit 1;
DE AltName: Full=Small nuclear RNA-activating complex polypeptide 1;
DE AltName: Full=snRNA-activating protein complex 43 kDa subunit;
DE Short=SNAPc 43 kDa subunit;
GN Name=Snapc1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Bone marrow, and Hypothalamus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Part of the SNAPc complex required for the transcription of
CC both RNA polymerase II and III small-nuclear RNA genes. Binds to the
CC proximal sequence element (PSE), a non-TATA-box basal promoter element
CC common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA
CC TATA box (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Part of the SNAPc complex composed of 5 subunits: SNAPC1,
CC SNAPC2, SNAPC3, SNAPC4 and SNAPC5. SNAPC1 interacts with SNAPC3, SNAPC4
CC and TBP (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
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DR EMBL; AK138261; BAE23598.1; -; mRNA.
DR EMBL; AK152833; BAE31533.1; -; mRNA.
DR EMBL; BC030456; AAH30456.1; -; mRNA.
DR CCDS; CCDS25978.1; -.
DR RefSeq; NP_848479.1; NM_178392.4.
DR AlphaFoldDB; Q8K0S9; -.
DR BioGRID; 217627; 2.
DR STRING; 10090.ENSMUSP00000021532; -.
DR iPTMnet; Q8K0S9; -.
DR PhosphoSitePlus; Q8K0S9; -.
DR EPD; Q8K0S9; -.
DR MaxQB; Q8K0S9; -.
DR PaxDb; Q8K0S9; -.
DR PRIDE; Q8K0S9; -.
DR ProteomicsDB; 261532; -.
DR DNASU; 75627; -.
DR Ensembl; ENSMUST00000021532; ENSMUSP00000021532; ENSMUSG00000021113.
DR GeneID; 75627; -.
DR KEGG; mmu:75627; -.
DR UCSC; uc007nwt.1; mouse.
DR CTD; 6617; -.
DR MGI; MGI:1922877; Snapc1.
DR VEuPathDB; HostDB:ENSMUSG00000021113; -.
DR eggNOG; KOG4746; Eukaryota.
DR GeneTree; ENSGT00390000018691; -.
DR HOGENOM; CLU_067254_0_0_1; -.
DR InParanoid; Q8K0S9; -.
DR OMA; LALAWQY; -.
DR OrthoDB; 1269640at2759; -.
DR PhylomeDB; Q8K0S9; -.
DR TreeFam; TF324445; -.
DR Reactome; R-MMU-6807505; RNA polymerase II transcribes snRNA genes.
DR Reactome; R-MMU-76071; RNA Polymerase III Transcription Initiation From Type 3 Promoter.
DR BioGRID-ORCS; 75627; 24 hits in 71 CRISPR screens.
DR ChiTaRS; Snapc1; mouse.
DR PRO; PR:Q8K0S9; -.
DR Proteomes; UP000000589; Chromosome 12.
DR RNAct; Q8K0S9; protein.
DR Bgee; ENSMUSG00000021113; Expressed in otolith organ and 223 other tissues.
DR ExpressionAtlas; Q8K0S9; baseline and differential.
DR Genevisible; Q8K0S9; MM.
DR GO; GO:0005730; C:nucleolus; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0019185; C:snRNA-activating protein complex; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0042795; P:snRNA transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0042796; P:snRNA transcription by RNA polymerase III; IBA:GO_Central.
DR InterPro; IPR019188; SNAPC1.
DR PANTHER; PTHR15131; PTHR15131; 1.
DR Pfam; PF09808; SNAPC1; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Nucleus; Phosphoprotein; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..389
FT /note="snRNA-activating protein complex subunit 1"
FT /id="PRO_0000072019"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 20..187
FT /note="SNAPC3-binding"
FT /evidence="ECO:0000250"
FT REGION 183..287
FT /note="SNAPC4-binding"
FT /evidence="ECO:0000250"
FT REGION 245..276
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 290..389
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 323..380
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 308
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q16533"
FT MOD_RES 309
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q16533"
SQ SEQUENCE 389 AA; 44576 MW; 89E9422F14A9193C CRC64;
MGTPAGAGTR PTGAGTVEGV GIPPGLQTDY ETLLSRFQEM DSVRFEDFTE LWRSMKFATI
FCGKMRNLKK NMFTKEALAL AWRYFLPPHT FQIRVGALYL LYGLYNTQLC QPKQKIRVAL
KDWDEVIRFQ QDLMNAQHFD AAFVFRKLRL DRAFHFTAMP KLLSCRMKKK VQQTEVTQKF
KDPNDRVMKL ITSDVLEEML NVHDHYQNMK HAISADKSMP DRALSLVKED FFENIKNIVL
EHQEWHKERK NPSLKPKLKD GEENGEGSSE EPERCERAVS LAKIKAKAFS AVVPVSKSRR
HRQSKLDSSD SDSGSGQVQG RAAKRKRTRE PAGPAGRKRS SRSKGNAPNE RKEEKSLHLS
MPIITEEEEE DMGGVRKAEF TAPKRKRKC
