SNPC2_HUMAN
ID SNPC2_HUMAN Reviewed; 334 AA.
AC Q13487; B2RBZ6; D6W663; Q13486;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 163.
DE RecName: Full=snRNA-activating protein complex subunit 2;
DE Short=SNAPc subunit 2;
DE AltName: Full=Proximal sequence element-binding transcription factor subunit delta;
DE Short=PSE-binding factor subunit delta;
DE Short=PTF subunit delta;
DE AltName: Full=Small nuclear RNA-activating complex polypeptide 2;
DE AltName: Full=snRNA-activating protein complex 45 kDa subunit;
DE Short=SNAPc 45 kDa subunit;
GN Name=SNAPC2; Synonyms=SNAP45;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Teratocarcinoma;
RX PubMed=8633057; DOI=10.1073/pnas.93.9.4289;
RA Sadowski C.L., Henry R.W., Kobayashi R., Hernandez N.;
RT "The SNAP45 subunit of the small nuclear RNA (snRNA) activating protein
RT complex is required for RNA polymerase II and III snRNA gene transcription
RT and interacts with the TATA box binding protein.";
RL Proc. Natl. Acad. Sci. U.S.A. 93:4289-4293(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=8524284; DOI=10.1128/mcb.16.1.1;
RA Yoon J.B., Roeder R.G.;
RT "Cloning of two proximal sequence element-binding transcription factor
RT subunits (gamma and delta) that are required for transcription of small
RT nuclear RNA genes by RNA polymerases II and III and interact with the TATA-
RT binding protein.";
RL Mol. Cell. Biol. 16:1-9(1996).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT VAL-118.
RC TISSUE=Lung;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT VAL-118.
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP INTERACTION WITH SNAPC4.
RX PubMed=9418884; DOI=10.1128/mcb.18.1.368;
RA Wong M.W., Henry R.W., Ma B., Kobayashi R., Klages N., Matthias P.,
RA Strubin M., Hernandez N.;
RT "The large subunit of basal transcription factor SNAPc is a Myb domain
RT protein that interacts with Oct-1.";
RL Mol. Cell. Biol. 18:368-377(1998).
RN [7]
RP INTERACTION WITH TBP.
RX PubMed=12621023; DOI=10.1074/jbc.m204247200;
RA Hinkley C.S., Hirsch H.A., Gu L., LaMere B., Henry R.W.;
RT "The small nuclear RNA-activating protein 190 Myb DNA binding domain
RT stimulates TATA box-binding protein-TATA box recognition.";
RL J. Biol. Chem. 278:18649-18657(2003).
CC -!- FUNCTION: Part of the SNAPc complex required for the transcription of
CC both RNA polymerase II and III small-nuclear RNA genes. Binds to the
CC proximal sequence element (PSE), a non-TATA-box basal promoter element
CC common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA
CC TATA box.
CC -!- SUBUNIT: Part of the SNAPc complex composed of 5 subunits: SNAPC1,
CC SNAPC2, SNAPC3, SNAPC4 and SNAPC5. SNAPC2 interacts with TBP and
CC SNAPC4. {ECO:0000269|PubMed:12621023, ECO:0000269|PubMed:9418884}.
CC -!- SUBCELLULAR LOCATION: Nucleus.
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DR EMBL; U44898; AAB06230.1; -; mRNA.
DR EMBL; U44755; AAC50359.1; -; mRNA.
DR EMBL; AK314878; BAG37393.1; -; mRNA.
DR EMBL; CH471139; EAW68957.1; -; Genomic_DNA.
DR EMBL; CH471139; EAW68958.1; -; Genomic_DNA.
DR EMBL; BC011868; AAH11868.1; -; mRNA.
DR CCDS; CCDS12190.1; -.
DR PIR; JC6082; JC6082.
DR RefSeq; NP_003074.1; NM_003083.3.
DR AlphaFoldDB; Q13487; -.
DR SMR; Q13487; -.
DR BioGRID; 112502; 8.
DR CORUM; Q13487; -.
DR DIP; DIP-505N; -.
DR IntAct; Q13487; 3.
DR MINT; Q13487; -.
DR STRING; 9606.ENSP00000221573; -.
DR iPTMnet; Q13487; -.
DR PhosphoSitePlus; Q13487; -.
DR BioMuta; SNAPC2; -.
DR DMDM; 8134714; -.
DR EPD; Q13487; -.
DR jPOST; Q13487; -.
DR MassIVE; Q13487; -.
DR MaxQB; Q13487; -.
DR PaxDb; Q13487; -.
DR PeptideAtlas; Q13487; -.
DR PRIDE; Q13487; -.
DR ProteomicsDB; 59480; -.
DR Antibodypedia; 12285; 146 antibodies from 22 providers.
DR DNASU; 6618; -.
DR Ensembl; ENST00000221573.11; ENSP00000221573.5; ENSG00000104976.12.
DR GeneID; 6618; -.
DR KEGG; hsa:6618; -.
DR MANE-Select; ENST00000221573.11; ENSP00000221573.5; NM_003083.4; NP_003074.1.
DR UCSC; uc002miw.3; human.
DR CTD; 6618; -.
DR DisGeNET; 6618; -.
DR GeneCards; SNAPC2; -.
DR HGNC; HGNC:11135; SNAPC2.
DR HPA; ENSG00000104976; Low tissue specificity.
DR MIM; 605076; gene.
DR neXtProt; NX_Q13487; -.
DR OpenTargets; ENSG00000104976; -.
DR PharmGKB; PA35983; -.
DR VEuPathDB; HostDB:ENSG00000104976; -.
DR eggNOG; ENOG502S260; Eukaryota.
DR GeneTree; ENSGT00390000017407; -.
DR HOGENOM; CLU_048442_0_0_1; -.
DR InParanoid; Q13487; -.
DR OMA; NCDPPQV; -.
DR OrthoDB; 1102879at2759; -.
DR PhylomeDB; Q13487; -.
DR TreeFam; TF336993; -.
DR PathwayCommons; Q13487; -.
DR Reactome; R-HSA-6807505; RNA polymerase II transcribes snRNA genes.
DR Reactome; R-HSA-749476; RNA Polymerase III Abortive And Retractive Initiation.
DR Reactome; R-HSA-76071; RNA Polymerase III Transcription Initiation From Type 3 Promoter.
DR SignaLink; Q13487; -.
DR BioGRID-ORCS; 6618; 739 hits in 1087 CRISPR screens.
DR ChiTaRS; SNAPC2; human.
DR GeneWiki; SNAPC2; -.
DR GenomeRNAi; 6618; -.
DR Pharos; Q13487; Tdark.
DR PRO; PR:Q13487; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q13487; protein.
DR Bgee; ENSG00000104976; Expressed in right uterine tube and 118 other tissues.
DR ExpressionAtlas; Q13487; baseline and differential.
DR Genevisible; Q13487; HS.
DR GO; GO:0005829; C:cytosol; IDA:HPA.
DR GO; GO:0016604; C:nuclear body; IDA:HPA.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0005634; C:nucleus; TAS:ProtInc.
DR GO; GO:0016251; F:RNA polymerase II general transcription initiation factor activity; NAS:ARUK-UCL.
DR GO; GO:0009301; P:snRNA transcription; TAS:ProtInc.
DR GO; GO:0006366; P:transcription by RNA polymerase II; TAS:ProtInc.
DR GO; GO:0006383; P:transcription by RNA polymerase III; TAS:ProtInc.
DR InterPro; IPR021281; SNAPC2.
DR PANTHER; PTHR15132; PTHR15132; 1.
DR Pfam; PF11035; SNAPC2; 1.
PE 1: Evidence at protein level;
KW Nucleus; Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..334
FT /note="snRNA-activating protein complex subunit 2"
FT /id="PRO_0000072020"
FT REGION 137..200
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 271..306
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 168..186
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 118
FT /note="L -> V (in dbSNP:rs475002)"
FT /evidence="ECO:0000269|PubMed:14702039, ECO:0000269|Ref.4"
FT /id="VAR_011806"
SQ SEQUENCE 334 AA; 35556 MW; 441894AF6E1F4083 CRC64;
MKPPPRRRAA PARYLGEVTG PATWSAREKR QLVRLLQARQ GQPEPDATEL ARELRGRSEA
EIRVFLQQLK GRVAREAIQK VHPGGLQGPR RREAQPPAPI EVWTDLAEKI TGPLEEALAV
AFSQVLTIAA TEPVTLLHSK PPKPTQARGK PLLLSAPGGQ EDPAPEIPSS APAAPSSAPR
TPDPAPEKPS ESSAGPSTEE DFAVDFEKIY KYLSSVSRSG RSPELSAAES AVVLDLLMSL
PEELPLLPCT ALVEHMTETY LRLTAPQPIP AGGSLGPAAE GDGAGSKAPE ETPPATEKAE
HSELKSPWQA AGICPLNPFL VPLELLGRAA TPAR
