SNPC2_MOUSE
ID SNPC2_MOUSE Reviewed; 359 AA.
AC Q91XA5; Q3UK17; Q8CBS9;
DT 15-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=snRNA-activating protein complex subunit 2;
DE Short=SNAPc subunit 2;
DE AltName: Full=Small nuclear RNA-activating complex polypeptide 2;
DE AltName: Full=snRNA-activating protein complex 45 kDa subunit;
DE Short=SNAPc 45 kDa subunit;
GN Name=Snapc2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and DBA/2J; TISSUE=Kidney, and Urinary bladder;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Liver;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Part of the SNAPc complex required for the transcription of
CC both RNA polymerase II and III small-nuclear RNA genes. Binds to the
CC proximal sequence element (PSE), a non-TATA-box basal promoter element
CC common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA
CC TATA box (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Part of the SNAPc complex composed of 5 subunits: SNAPC1,
CC SNAPC2, SNAPC3, SNAPC4 and SNAPC5. SNAPC2 interacts with TBP and SNAPC4
CC (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
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DR EMBL; AK035340; BAC29039.1; -; mRNA.
DR EMBL; AK075569; BAC35827.1; -; mRNA.
DR EMBL; AK146218; BAE26986.1; -; mRNA.
DR EMBL; BC011147; AAH11147.1; -; mRNA.
DR CCDS; CCDS22081.1; -.
DR RefSeq; NP_598729.1; NM_133968.1.
DR AlphaFoldDB; Q91XA5; -.
DR STRING; 10090.ENSMUSP00000011981; -.
DR iPTMnet; Q91XA5; -.
DR PhosphoSitePlus; Q91XA5; -.
DR MaxQB; Q91XA5; -.
DR PaxDb; Q91XA5; -.
DR PRIDE; Q91XA5; -.
DR ProteomicsDB; 261292; -.
DR Antibodypedia; 12285; 146 antibodies from 22 providers.
DR DNASU; 102209; -.
DR Ensembl; ENSMUST00000011981; ENSMUSP00000011981; ENSMUSG00000011837.
DR GeneID; 102209; -.
DR KEGG; mmu:102209; -.
DR UCSC; uc009kto.1; mouse.
DR CTD; 6618; -.
DR MGI; MGI:1914861; Snapc2.
DR VEuPathDB; HostDB:ENSMUSG00000011837; -.
DR eggNOG; ENOG502S260; Eukaryota.
DR GeneTree; ENSGT00390000017407; -.
DR HOGENOM; CLU_048442_0_0_1; -.
DR InParanoid; Q91XA5; -.
DR OMA; KVPIELW; -.
DR OrthoDB; 1102879at2759; -.
DR PhylomeDB; Q91XA5; -.
DR TreeFam; TF336993; -.
DR Reactome; R-MMU-6807505; RNA polymerase II transcribes snRNA genes.
DR Reactome; R-MMU-76071; RNA Polymerase III Transcription Initiation From Type 3 Promoter.
DR BioGRID-ORCS; 102209; 18 hits in 73 CRISPR screens.
DR ChiTaRS; Snapc2; mouse.
DR PRO; PR:Q91XA5; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q91XA5; protein.
DR Bgee; ENSMUSG00000011837; Expressed in internal carotid artery and 260 other tissues.
DR ExpressionAtlas; Q91XA5; baseline and differential.
DR Genevisible; Q91XA5; MM.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0016604; C:nuclear body; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0016251; F:RNA polymerase II general transcription initiation factor activity; IEA:InterPro.
DR GO; GO:0009301; P:snRNA transcription; IEA:InterPro.
DR InterPro; IPR021281; SNAPC2.
DR PANTHER; PTHR15132; PTHR15132; 1.
DR Pfam; PF11035; SNAPC2; 1.
PE 2: Evidence at transcript level;
KW Nucleus; Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..359
FT /note="snRNA-activating protein complex subunit 2"
FT /id="PRO_0000072021"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 157..221
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 291..327
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 51
FT /note="A -> D (in Ref. 1; BAC29039)"
FT /evidence="ECO:0000305"
FT CONFLICT 195
FT /note="P -> T (in Ref. 1; BAC29039)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 359 AA; 38370 MW; 1F69C9B571B00D52 CRC64;
MKPPQRRRRV PARYVGEATG PTAWSPREMR HLLRLLQARR GQPEPDAAEL AQELRGRSEA
EICRFIQQLK GRVVREAIQK MQPGGREGPR HQGTPLPAPV EVWMDLAEKL TGPMEEALTA
AFSQVLTIAA AEPLSLLHSR PGKPTKARGK ALVFLSNQDG QKDPASEGSG PVPMTAADPT
REASVSDPKA SGANPETSGL ASEVTVPDPD APTKSLAGSS TERDLAVDFE KIYKYLSFSS
RGGHGPELSA AESAVVLNLL MALPEELSHL PCTALLEHMT KTYAQLMAPQ TALPGEKRPR
PGTEDGGTGS TGPEEPDQAS PQASEPIEPR LAWKAVGICP LNPFLVPLGL VSQAPSPSR
