SNPC4_CAEEL
ID SNPC4_CAEEL Reviewed; 944 AA.
AC P91868; O62208;
DT 27-MAY-2015, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1997, sequence version 1.
DT 03-AUG-2022, entry version 169.
DE RecName: Full=snRNA-activating protein complex subunit 4 homolog {ECO:0000312|WormBase:F32H2.1a};
DE Short=SNAPc subunit 4 homolog {ECO:0000250|UniProtKB:Q5SXM2};
GN Name=snpc-4 {ECO:0000312|WormBase:F32H2.1a};
GN Synonyms=gei-11 {ECO:0000303|PubMed:25373775};
GN ORFNames=F32H2.1 {ECO:0000312|WormBase:F32H2.1a};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1] {ECO:0000312|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2] {ECO:0000305}
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE,
RP AND DISRUPTION PHENOTYPE.
RX PubMed=25373775; DOI=10.1016/j.devcel.2014.09.015;
RA Kasper D.M., Wang G., Gardner K.E., Johnstone T.G., Reinke V.;
RT "The C. elegans SNAPc component SNPC-4 coats piRNA domains and is globally
RT required for piRNA abundance.";
RL Dev. Cell 31:145-158(2014).
CC -!- FUNCTION: Binds to the promoter regions of RNA polymerase II and III
CC small-nuclear RNA genes, type 3 RNA polymerase III non-coding RNA
CC genes, small nucleolar RNAs and transfer RNA genes. Required for
CC expression of mature 21U-RNAs. {ECO:0000269|PubMed:25373775}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625,
CC ECO:0000269|PubMed:25373775}. Note=Diffuse nuclear localization.
CC Concentrated in foci within nuclei of proliferating and pachytene germ
CC cells. Foci localization is dependent on prde-1 activity.
CC {ECO:0000269|PubMed:25373775}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=a {ECO:0000312|WormBase:F32H2.1a};
CC IsoId=P91868-1; Sequence=Displayed;
CC Name=b {ECO:0000312|WormBase:F32H2.1b};
CC IsoId=P91868-2; Sequence=VSP_057656;
CC -!- TISSUE SPECIFICITY: Broadly expressed in all tissues, including head,
CC vulva and tail. {ECO:0000269|PubMed:25373775}.
CC -!- DEVELOPMENTAL STAGE: Expressed throughout development.
CC {ECO:0000269|PubMed:25373775}.
CC -!- DISRUPTION PHENOTYPE: RNAi-mediated knockdown from larval stage L1
CC results in decreased 21U-RNA expression and disrupted distribution of
CC prde-1 foci within the nuclei of germ cells.
CC {ECO:0000269|PubMed:25373775}.
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DR EMBL; Z81523; CAB04241.1; -; Genomic_DNA.
DR EMBL; Z81523; CAB04248.1; -; Genomic_DNA.
DR PIR; T21673; T21673.
DR PIR; T21680; T21680.
DR RefSeq; NP_492411.1; NM_060010.4. [P91868-1]
DR RefSeq; NP_492412.1; NM_060011.4. [P91868-2]
DR AlphaFoldDB; P91868; -.
DR SMR; P91868; -.
DR IntAct; P91868; 1.
DR MINT; P91868; -.
DR STRING; 6239.F32H2.1a; -.
DR EPD; P91868; -.
DR PaxDb; P91868; -.
DR PeptideAtlas; P91868; -.
DR EnsemblMetazoa; F32H2.1a.1; F32H2.1a.1; WBGene00001568. [P91868-1]
DR EnsemblMetazoa; F32H2.1b.1; F32H2.1b.1; WBGene00001568. [P91868-2]
DR GeneID; 172711; -.
DR KEGG; cel:CELE_F32H2.1; -.
DR UCSC; F32H2.1b; c. elegans.
DR CTD; 172711; -.
DR WormBase; F32H2.1a; CE09876; WBGene00001568; snpc-4. [P91868-1]
DR WormBase; F32H2.1b; CE17749; WBGene00001568; snpc-4. [P91868-2]
DR eggNOG; KOG0049; Eukaryota.
DR GeneTree; ENSGT00940000160404; -.
DR HOGENOM; CLU_318916_0_0_1; -.
DR InParanoid; P91868; -.
DR OMA; NDSQCRE; -.
DR OrthoDB; 298788at2759; -.
DR Reactome; R-CEL-6807505; RNA polymerase II transcribes snRNA genes.
DR PRO; PR:P91868; -.
DR Proteomes; UP000001940; Chromosome I.
DR Bgee; WBGene00001568; Expressed in embryo and 4 other tissues.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0019185; C:snRNA-activating protein complex; IBA:GO_Central.
DR GO; GO:0001006; F:RNA polymerase III type 3 promoter sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0042795; P:snRNA transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0042796; P:snRNA transcription by RNA polymerase III; IBA:GO_Central.
DR CDD; cd00167; SANT; 4.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017930; Myb_dom.
DR InterPro; IPR001005; SANT/Myb.
DR Pfam; PF00249; Myb_DNA-binding; 3.
DR SMART; SM00717; SANT; 5.
DR SUPFAM; SSF46689; SSF46689; 3.
DR PROSITE; PS51294; HTH_MYB; 3.
DR PROSITE; PS50090; MYB_LIKE; 2.
PE 2: Evidence at transcript level;
KW Alternative splicing; DNA-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation.
FT CHAIN 1..944
FT /note="snRNA-activating protein complex subunit 4 homolog"
FT /id="PRO_0000433018"
FT DOMAIN 177..244
FT /note="Myb-like 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00133"
FT DOMAIN 245..301
FT /note="HTH myb-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DOMAIN 304..350
FT /note="Myb-like 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00133"
FT DOMAIN 351..406
FT /note="HTH myb-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DOMAIN 407..459
FT /note="HTH myb-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DNA_BIND 273..297
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DNA_BIND 379..402
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DNA_BIND 432..455
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 911..935
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7..22
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 921..935
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 889..904
FT /note="Missing (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_057656"
SQ SEQUENCE 944 AA; 109487 MW; B39BB67DF4E1F5D0 CRC64;
MSDLVMFEPG ASTSTDVPTN TDQTAMSTTQ VVDALECDTF EGLMNVNETY VEILDSALLS
VQQHLDDNLK RQQQLKEEYR LYNRADITKR KVPVHLYMPP YFKDDNNMYP PMSSEAREKQ
VLKWFDPMMK EEKKWTPSEI KTLRTSVKNA LVAHQVQPWC SRRDIVASKL RDADITTSNF
DRRQWTMELE DLMRKIAYVR EKSEEEVLTA SADYTVVPWT AIANFDFKGS RTEWAVKSKW
YNELNPKWNK EHWSNEEVEK LKYLRESPKF VSWPMLALNL GTNRTSYQCM EKYKTEVSQH
SKEWSQDEDT KLIALTKITS INGHIQWDKV AQCMPGRTRQ QVRTRFSHTL DASVKHGRWT
DQEDVLLVCA VSRYGAKDWA KVAQAVQNRN DSQCRERWTN VLNRSAHVNE RFTLVEDEQL
LYAVKVFGKG NWAKCQMLLP KKTSRQLRRR YLQLIAAKLR LAAGFCNAVD AMKSGRRAPE
EDELEQEDIV EAEQIPNELM KEVYEKFANE NPDMNETPEE FYKRVSALER PAAARIRALK
NKPDYQKIQD KINEIVQKHK NAAEIDKELH SSEILSSLTI TEVDVRYMIE RSKTLTRYYE
ARQFRKNVDQ IGCRVRPIKI DLDPETMPTF DPNDAEDEKQ MVIVESLCSV IRAHDVKEWG
TKFWNEHRFT APKYAKRFVE NMVINKSKEV AEWYLHVNSK SCNQNDVHCP AKSTLPPTAA
SFDLHKMLQK ARSGLNRLSA EHFYPLDVSL AQQFNFKNDE REGLDGDRRM HIGLSDEVTN
SKEYANFYAR MRSILLEPMR LGIARESSSD ETKRLVRCLA EERACDEEQQ VTCDQIRRRR
MPDDEIYVTP TSISRELNNG MKIDTTELLA NLDKNSAKKI RMKRKIGEVR CDTKIKLLPL
VILATVATVA ARPARPPRSS AGTPTPSHVS IDTESNISLK VELD
