SNPC5_MOUSE
ID SNPC5_MOUSE Reviewed; 98 AA.
AC Q8R2K7;
DT 15-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 25-MAY-2022, entry version 104.
DE RecName: Full=snRNA-activating protein complex subunit 5;
DE Short=SNAPc subunit 5;
DE AltName: Full=Small nuclear RNA-activating complex polypeptide 5;
DE AltName: Full=snRNA-activating protein complex 19 kDa subunit;
DE Short=SNAPc 19 kDa subunit;
GN Name=Snapc5;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Part of the SNAPc complex required for the transcription of
CC both RNA polymerase II and III small-nuclear RNA genes. Binds to the
CC proximal sequence element (PSE), a non-TATA-box basal promoter element
CC common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA
CC TATA box (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Part of the SNAPc complex composed of 5 subunits: SNAPC1,
CC SNAPC2, SNAPC3, SNAPC4 and SNAPC5. SNAPC5 interacts with SNAPC4 (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
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DR EMBL; BC028529; AAH28529.1; -; mRNA.
DR RefSeq; NP_899139.2; NM_183316.2.
DR AlphaFoldDB; Q8R2K7; -.
DR SMR; Q8R2K7; -.
DR BioGRID; 237056; 2.
DR STRING; 10090.ENSMUSP00000034965; -.
DR PhosphoSitePlus; Q8R2K7; -.
DR PaxDb; Q8R2K7; -.
DR PRIDE; Q8R2K7; -.
DR ProteomicsDB; 261534; -.
DR DNASU; 330959; -.
DR GeneID; 330959; -.
DR KEGG; mmu:330959; -.
DR CTD; 10302; -.
DR MGI; MGI:1914282; Snapc5.
DR eggNOG; ENOG502S8MI; Eukaryota.
DR InParanoid; Q8R2K7; -.
DR OrthoDB; 1586356at2759; -.
DR PhylomeDB; Q8R2K7; -.
DR Reactome; R-MMU-6807505; RNA polymerase II transcribes snRNA genes.
DR Reactome; R-MMU-76071; RNA Polymerase III Transcription Initiation From Type 3 Promoter.
DR BioGRID-ORCS; 330959; 30 hits in 70 CRISPR screens.
DR ChiTaRS; Snapc5; mouse.
DR PRO; PR:Q8R2K7; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q8R2K7; protein.
DR GO; GO:0016604; C:nuclear body; ISO:MGI.
DR GO; GO:0005730; C:nucleolus; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0016251; F:RNA polymerase II general transcription initiation factor activity; ISO:MGI.
DR GO; GO:0000995; F:RNA polymerase III general transcription initiation factor activity; ISO:MGI.
DR GO; GO:0042795; P:snRNA transcription by RNA polymerase II; ISO:MGI.
DR GO; GO:0042796; P:snRNA transcription by RNA polymerase III; ISO:MGI.
DR GO; GO:0006384; P:transcription initiation from RNA polymerase III promoter; IEA:InterPro.
DR InterPro; IPR029138; SNAPC5.
DR PANTHER; PTHR15333; PTHR15333; 1.
DR Pfam; PF15497; SNAPC5; 1.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..98
FT /note="snRNA-activating protein complex subunit 5"
FT /id="PRO_0000072029"
FT REGION 75..98
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 98 AA; 11340 MW; B33117DFA0A2FCE3 CRC64;
MLSRLQELRK EEETLLRLKA ALHDQLNRLK VEELALQSMI NSRGRTETLS SQPAPEQLCD
MSLHVDNEVT INQTTLKLST RSPMEEEEEE EEEEESDS
