SNPF_AEDAE
ID SNPF_AEDAE Reviewed; 215 AA.
AC A0SIX6; Q16LS3;
DT 17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 17-APR-2007, sequence version 2.
DT 25-MAY-2022, entry version 62.
DE RecName: Full=Short neuropeptide F;
DE Contains:
DE RecName: Full=sNPF-associated peptide;
DE Contains:
DE RecName: Full=sNPF peptide 2;
DE Contains:
DE RecName: Full=sNPF peptide 3;
DE Contains:
DE RecName: Full=RLRF peptide 1;
DE Contains:
DE RecName: Full=RLRF peptide 2;
DE Contains:
DE RecName: Full=RLRF peptide 3;
DE Contains:
DE RecName: Full=RLRW peptide;
DE Flags: Precursor;
GN Name=sNPF {ECO:0000250|UniProtKB:Q9VIQ0}; ORFNames=AAEL012542;
OS Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Aedini; Aedes; Stegomyia.
OX NCBI_TaxID=7159;
RN [1] {ECO:0000305, ECO:0000312|EMBL:ABE72968.1}
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A).
RC TISSUE=Head {ECO:0000312|EMBL:ABE72968.1};
RX PubMed=17140700; DOI=10.1016/j.peptides.2006.09.019;
RA Garczynski S.F., Crim J.W., Brown M.R.;
RT "Characterization and expression of the short neuropeptide F receptor in
RT the African malaria mosquito, Anopheles gambiae.";
RL Peptides 28:109-118(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LVPib12;
RX PubMed=17510324; DOI=10.1126/science.1138878;
RA Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F.,
RA Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.,
RA Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L.,
RA Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J.,
RA Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E.,
RA El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I.,
RA Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H.,
RA Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S.,
RA Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P.,
RA Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R.,
RA Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B.,
RA Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T.,
RA Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.;
RT "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL Science 316:1718-1723(2007).
CC -!- FUNCTION: Plays a role in controlling food intake and regulating body
CC size. {ECO:0000250|UniProtKB:Q9VIQ0}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=A {ECO:0000269|PubMed:17140700};
CC IsoId=A0SIX6-1; Sequence=Displayed;
CC Name=B;
CC IsoId=A0SIX6-2; Sequence=VSP_052376;
CC -!- SIMILARITY: Belongs to the NPY family. {ECO:0000255}.
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DR EMBL; DQ459411; ABE72968.1; -; mRNA.
DR EMBL; CH477894; EAT35275.1; -; Genomic_DNA.
DR RefSeq; XP_001662646.1; XM_001662596.1.
DR AlphaFoldDB; A0SIX6; -.
DR STRING; 7159.AAEL012542-PA; -.
DR VEuPathDB; VectorBase:AAEL019691; -.
DR eggNOG; ENOG502SEMZ; Eukaryota.
DR HOGENOM; CLU_1171457_0_0_1; -.
DR InParanoid; A0SIX6; -.
DR OMA; YADHQIK; -.
DR Proteomes; UP000008820; Chromosome 2.
DR GO; GO:0005576; C:extracellular region; ISS:UniProtKB.
DR GO; GO:0005184; F:neuropeptide hormone activity; ISS:UniProtKB.
DR GO; GO:0007218; P:neuropeptide signaling pathway; ISS:UniProtKB.
DR GO; GO:0040014; P:regulation of multicellular organism growth; ISS:UniProtKB.
DR GO; GO:0032095; P:regulation of response to food; ISS:UniProtKB.
PE 2: Evidence at transcript level;
KW Alternative splicing; Amidation; Cleavage on pair of basic residues;
KW Neuropeptide; Reference proteome; Secreted; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT PROPEP 23..56
FT /evidence="ECO:0000250|UniProtKB:Q9VIQ0"
FT /id="PRO_0000284734"
FT PEPTIDE 59..69
FT /note="RLRF peptide 1"
FT /evidence="ECO:0000250|UniProtKB:Q9VIQ0"
FT /id="PRO_0000284735"
FT PEPTIDE 73..89
FT /note="sNPF-associated peptide"
FT /evidence="ECO:0000250|UniProtKB:Q9VIQ0"
FT /id="PRO_0000284736"
FT PEPTIDE 91..101
FT /note="RLRF peptide 2"
FT /evidence="ECO:0000250|UniProtKB:Q9VIQ0"
FT /id="PRO_0000284737"
FT PEPTIDE 104..119
FT /note="sNPF peptide 2"
FT /evidence="ECO:0000250|UniProtKB:Q9VIQ0"
FT /id="PRO_0000284738"
FT PEPTIDE 122..129
FT /note="RLRW peptide"
FT /evidence="ECO:0000250|UniProtKB:A0SIF1"
FT /id="PRO_0000284739"
FT PEPTIDE 132..145
FT /note="sNPF peptide 3"
FT /evidence="ECO:0000250|UniProtKB:A0SIF1"
FT /id="PRO_0000284740"
FT PEPTIDE 147..157
FT /note="RLRF peptide 3"
FT /evidence="ECO:0000250|UniProtKB:A0SIF1"
FT /id="PRO_0000284741"
FT PROPEP 160..215
FT /evidence="ECO:0000250|UniProtKB:A0SIF1"
FT /id="PRO_0000284742"
FT REGION 173..215
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 177..206
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 69
FT /note="Phenylalanine amide"
FT /evidence="ECO:0000250"
FT MOD_RES 101
FT /note="Phenylalanine amide"
FT /evidence="ECO:0000250"
FT MOD_RES 129
FT /note="Tryptophan amide"
FT /evidence="ECO:0000250"
FT MOD_RES 157
FT /note="Phenylalanine amide"
FT /evidence="ECO:0000250"
FT VAR_SEQ 201..215
FT /note="QVESEENSPSNMDEK -> SAQCVSSSEAQR (in isoform B)"
FT /evidence="ECO:0000305"
FT /id="VSP_052376"
FT CONFLICT 14
FT /note="V -> A (in Ref. 1; ABE72968)"
FT /evidence="ECO:0000305"
FT CONFLICT 77
FT /note="V -> M (in Ref. 1; ABE72968)"
FT /evidence="ECO:0000305"
FT CONFLICT 162
FT /note="P -> T (in Ref. 1; ABE72968)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 215 AA; 24637 MW; 1A0236899C40B0A8 CRC64;
MCRINFTTLS LILVLWSGSL MSEPSQNADG SIKGLYEYLL QREYAAPVSY ADHQIKRKAV
RSPSLRLRFG RRSDPSVPVE PEDDDMVDQR SIRAPQLRLR FGRTDPLWSS FNENALLEEK
RAPSQRLRWG RSGGGMFSTN DVMQQKAIRA PQLRLRFGRS DPSWAMFNEH QLDEQQFADA
TRQPSKTLRG DEPTSIESTE QVESEENSPS NMDEK
