ID   SNPF_ANOGA              Reviewed;         234 AA.
AC   A0SIF1;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2007, sequence version 1.
DT   25-MAY-2022, entry version 22.
DE   RecName: Full=Short neuropeptide F;
DE   Contains:
DE     RecName: Full=sNPF-associated peptide;
DE   Contains:
DE     RecName: Full=sNPF peptide 2;
DE   Contains:
DE     RecName: Full=sNPF peptide 3;
DE   Contains:
DE     RecName: Full=sNPF peptide 4;
DE   Contains:
DE     RecName: Full=RLRF peptide 1;
DE   Contains:
DE     RecName: Full=RLRF peptide 2;
DE   Contains:
DE     RecName: Full=RLRF peptide 3;
DE   Contains:
DE     RecName: Full=RLRW peptide 1;
DE   Contains:
DE     RecName: Full=RLRW peptide 2;
DE   Flags: Precursor;
GN   Name=sNPF {ECO:0000250|UniProtKB:Q9VIQ0};
OS   Anopheles gambiae (African malaria mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=7165;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:ABD96048.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], AMIDATION AT PHE-69; PHE-101; TRP-132; PHE-165
RP   AND TRP-204, AND TISSUE SPECIFICITY.
RC   STRAIN=G3;
RX   PubMed=17140700; DOI=10.1016/j.peptides.2006.09.019;
RA   Garczynski S.F., Crim J.W., Brown M.R.;
RT   "Characterization and expression of the short neuropeptide F receptor in
RT   the African malaria mosquito, Anopheles gambiae.";
RL   Peptides 28:109-118(2007).
CC   -!- FUNCTION: Plays a role in controlling food intake and regulating body
CC       size. {ECO:0000250|UniProtKB:Q9VIQ0}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed in all body parts of larva, pupae and
CC       adults. {ECO:0000269|PubMed:17140700}.
CC   -!- SIMILARITY: Belongs to the NPY family. {ECO:0000255}.
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DR   EMBL; DQ437578; ABD96048.1; -; mRNA.
DR   AlphaFoldDB; A0SIF1; -.
DR   Proteomes; UP000007062; Unplaced.
DR   GO; GO:0005576; C:extracellular region; ISS:UniProtKB.
DR   GO; GO:0005184; F:neuropeptide hormone activity; ISS:UniProtKB.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; ISS:UniProtKB.
DR   GO; GO:0040014; P:regulation of multicellular organism growth; ISS:UniProtKB.
DR   GO; GO:0032095; P:regulation of response to food; ISS:UniProtKB.
PE   1: Evidence at protein level;
KW   Amidation; Cleavage on pair of basic residues; Neuropeptide;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   PROPEP          23..56
FT                   /evidence="ECO:0000250|UniProtKB:Q9VIQ0"
FT                   /id="PRO_0000287899"
FT   PEPTIDE         59..69
FT                   /note="RLRF peptide 1"
FT                   /evidence="ECO:0000250|UniProtKB:Q9VIQ0"
FT                   /id="PRO_0000287900"
FT   PEPTIDE         73..89
FT                   /note="sNPF-associated peptide"
FT                   /evidence="ECO:0000250|UniProtKB:Q9VIQ0"
FT                   /id="PRO_0000287901"
FT   PEPTIDE         91..101
FT                   /note="RLRF peptide 2"
FT                   /evidence="ECO:0000250|UniProtKB:Q9VIQ0"
FT                   /id="PRO_0000287902"
FT   PEPTIDE         104..122
FT                   /note="sNPF peptide 2"
FT                   /evidence="ECO:0000269|PubMed:17140700"
FT                   /id="PRO_0000287903"
FT   PEPTIDE         125..132
FT                   /note="RLRW peptide 1"
FT                   /evidence="ECO:0000269|PubMed:17140700"
FT                   /id="PRO_0000287904"
FT   PEPTIDE         135..153
FT                   /note="sNPF peptide 3"
FT                   /evidence="ECO:0000269|PubMed:17140700"
FT                   /id="PRO_0000287905"
FT   PEPTIDE         155..165
FT                   /note="RLRF peptide 3"
FT                   /evidence="ECO:0000269|PubMed:17140700"
FT                   /id="PRO_0000287906"
FT   PEPTIDE         168..194
FT                   /note="sNPF peptide 4"
FT                   /evidence="ECO:0000269|PubMed:17140700"
FT                   /id="PRO_0000287907"
FT   PEPTIDE         197..204
FT                   /note="RLRW peptide 2"
FT                   /evidence="ECO:0000269|PubMed:17140700"
FT                   /id="PRO_0000287908"
FT   PROPEP          207..234
FT                   /evidence="ECO:0000269|PubMed:17140700"
FT                   /id="PRO_0000287909"
FT   REGION          181..234
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        196..234
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         69
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000269|PubMed:17140700"
FT   MOD_RES         101
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000269|PubMed:17140700"
FT   MOD_RES         132
FT                   /note="Tryptophan amide"
FT                   /evidence="ECO:0000269|PubMed:17140700"
FT   MOD_RES         165
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000269|PubMed:17140700"
FT   MOD_RES         204
FT                   /note="Tryptophan amide"
FT                   /evidence="ECO:0000269|PubMed:17140700"
SQ   SEQUENCE   234 AA;  26997 MW;  064A2F5D0E7B41FF CRC64;
     MYRINLTTFT LLLVLAVGSL MSESLHPSDG AINDLYEYLL QREYAAPVSY ADHQIKRKAV
     RSPSLRLRFG RRSDPSVPLR PEEDELIDQK AIRAPQLRLR FGRNDPLWTS FNENALLEEN
     FEKRAPSQRL RWGRSNLFGN LVNQFQQDDV MQQKTIRAPQ LRLRFGRTDP SWAMYNEHQL
     TTGQQAQPAN EASEKRAPTQ RLRWGRSDPA LAKDSSEDKA LDVEESENTN ADDK