ID   SNPF_DROPS              Reviewed;         290 AA.
AC   Q29KK2;
DT   17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   17-APR-2007, sequence version 2.
DT   25-MAY-2022, entry version 49.
DE   RecName: Full=Short neuropeptide F;
DE   Contains:
DE     RecName: Full=sNPF-associated peptide;
DE   Contains:
DE     RecName: Full=sNPF peptide 2;
DE   Contains:
DE     RecName: Full=RLRF peptide 1;
DE   Contains:
DE     RecName: Full=RLRF peptide 2;
DE   Flags: Precursor;
GN   Name=sNPF {ECO:0000250|UniProtKB:Q9VIQ0}; ORFNames=GA12665;
OS   Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=46245;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MV2-25 / Tucson 14011-0121.94;
RX   PubMed=15632085; DOI=10.1101/gr.3059305;
RA   Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA   Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA   Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA   Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA   Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA   Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA   Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA   Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA   Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA   Weinstock G.M., Gibbs R.A.;
RT   "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT   gene, and cis-element evolution.";
RL   Genome Res. 15:1-18(2005).
CC   -!- FUNCTION: Plays a role in controlling food intake and regulating body
CC       size. {ECO:0000250|UniProtKB:Q9VIQ0}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NPY family. {ECO:0000255}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAL33172.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; CH379061; EAL33172.2; ALT_SEQ; Genomic_DNA.
DR   AlphaFoldDB; Q29KK2; -.
DR   STRING; 7237.FBpp0287442; -.
DR   eggNOG; ENOG502SEMZ; Eukaryota.
DR   InParanoid; Q29KK2; -.
DR   Proteomes; UP000001819; Genome assembly.
DR   GO; GO:0005576; C:extracellular region; ISS:UniProtKB.
DR   GO; GO:0005184; F:neuropeptide hormone activity; ISS:UniProtKB.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; ISS:UniProtKB.
DR   GO; GO:0040014; P:regulation of multicellular organism growth; ISS:UniProtKB.
DR   GO; GO:0032095; P:regulation of response to food; ISS:UniProtKB.
PE   3: Inferred from homology;
KW   Amidation; Cleavage on pair of basic residues; Neuropeptide;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..32
FT                   /evidence="ECO:0000255"
FT   PROPEP          33..87
FT                   /evidence="ECO:0000250|UniProtKB:Q9VIQ0"
FT                   /id="PRO_0000284743"
FT   PEPTIDE         90..100
FT                   /note="RLRF peptide 1"
FT                   /evidence="ECO:0000250|UniProtKB:Q9VIQ0"
FT                   /id="PRO_0000284744"
FT   PEPTIDE         103..113
FT                   /note="sNPF-associated peptide"
FT                   /evidence="ECO:0000250|UniProtKB:Q9VIQ0"
FT                   /id="PRO_0000284745"
FT   PEPTIDE         116..125
FT                   /note="sNPF peptide 2"
FT                   /evidence="ECO:0000250|UniProtKB:Q9VIQ0"
FT                   /id="PRO_0000284746"
FT   PEPTIDE         127..134
FT                   /note="RLRF peptide 2"
FT                   /evidence="ECO:0000250|UniProtKB:Q9VIQ0"
FT                   /id="PRO_0000284747"
FT   PROPEP          138..290
FT                   /evidence="ECO:0000250|UniProtKB:Q9VIQ0"
FT                   /id="PRO_0000284748"
FT   REGION          238..290
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        254..269
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         100
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         134
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   290 AA;  33281 MW;  84D02B965CC1B3A8 CRC64;
     MFRFNPQLSH GCALALICCL LNLLMMHQPT NAELSPVVQG EFFLPILPDD HPPNTDTSFG
     GPISNLYDNL LQREYAGPVV FPNHQVERKA QRSPSLRLRF GRSDPDMLNN IVEKRWFGDV
     NQKPIRSPSL RLRFGRRDPT LPQMRRTAYD DLLERELTLN NQQQQQLGDT ADDLSADYDG
     LYERVVRKPQ RLRWGRSVPQ FEATIGDNDQ LYNSLWNSEK MRRMLLALQQ YEAAPGHVAG
     YANDGDDTEA QLDEDTSEFQ REARKPMRLR WGRSTGKAPQ IETSSIAPKN