SNR25_HUMAN
ID SNR25_HUMAN Reviewed; 132 AA.
AC Q9BV90; Q1W6H3; Q6IEF8; Q9H5W4;
DT 21-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=U11/U12 small nuclear ribonucleoprotein 25 kDa protein;
DE Short=U11/U12 snRNP 25 kDa protein;
DE Short=U11/U12-25K;
DE AltName: Full=Minus-99 protein;
GN Name=SNRNP25; Synonyms=C16orf33;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=16728641; DOI=10.1126/science.1126431;
RA De Gobbi M., Viprakasit V., Hughes J.R., Fisher C., Buckle V.J., Ayyub H.,
RA Gibbons R.J., Vernimmen D., Yoshinaga Y., de Jong P., Cheng J.-F.,
RA Rubin E.M., Wood W.G., Bowden D., Higgs D.R.;
RT "A regulatory SNP causes a human genetic disease by creating a new
RT transcriptional promoter.";
RL Science 312:1215-1217(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15616553; DOI=10.1038/nature03187;
RA Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G.,
RA Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E.,
RA Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., Buckingham J.M.,
RA Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C.,
RA Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M.,
RA Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M.,
RA Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D.,
RA Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L.,
RA Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E.,
RA Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H.,
RA Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y.,
RA Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S.,
RA Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A.,
RA Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M.,
RA Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H.,
RA Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A.,
RA Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J.,
RA DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J.,
RA Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M.,
RA Myers R.M., Rubin E.M., Pennacchio L.A.;
RT "The sequence and analysis of duplication-rich human chromosome 16.";
RL Nature 432:988-994(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Colon, and Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION IN A COMPLEX WITH THE U11/U12 SPLICEOSOME, SUBCELLULAR
RP LOCATION, AND IDENTIFICATION BY MASS SPECTROMETRY.
RX PubMed=15146077; DOI=10.1261/rna.7320604;
RA Will C.L., Schneider C., Hossbach M., Urlaub H., Rauhut R., Elbashir S.,
RA Tuschl T., Luehrmann R.;
RT "The human 18S U11/U12 snRNP contains a set of novel proteins not found in
RT the U2-dependent spliceosome.";
RL RNA 10:929-941(2004).
CC -!- SUBUNIT: Component of the U11/U12 snRNPs that are part of the U12-type
CC spliceosome. {ECO:0000269|PubMed:15146077}.
CC -!- INTERACTION:
CC Q9BV90; Q9NP55: BPIFA1; NbExp=3; IntAct=EBI-9675976, EBI-953896;
CC Q9BV90; Q8N684: CPSF7; NbExp=3; IntAct=EBI-9675976, EBI-746909;
CC Q9BV90; Q8N684-3: CPSF7; NbExp=3; IntAct=EBI-9675976, EBI-11523759;
CC Q9BV90; Q5JST6: EFHC2; NbExp=6; IntAct=EBI-9675976, EBI-2349927;
CC Q9BV90; Q15323: KRT31; NbExp=3; IntAct=EBI-9675976, EBI-948001;
CC Q9BV90; Q9UBR4-2: LHX3; NbExp=7; IntAct=EBI-9675976, EBI-12039345;
CC Q9BV90; Q969G2: LHX4; NbExp=6; IntAct=EBI-9675976, EBI-2865388;
CC Q9BV90; Q8TBB1: LNX1; NbExp=3; IntAct=EBI-9675976, EBI-739832;
CC Q9BV90; Q6ZUT1: NKAPD1; NbExp=3; IntAct=EBI-9675976, EBI-3920396;
CC Q9BV90; O43482: OIP5; NbExp=3; IntAct=EBI-9675976, EBI-536879;
CC Q9BV90; Q99471: PFDN5; NbExp=3; IntAct=EBI-9675976, EBI-357275;
CC Q9BV90; Q9NRD5: PICK1; NbExp=3; IntAct=EBI-9675976, EBI-79165;
CC Q9BV90; Q04864: REL; NbExp=3; IntAct=EBI-9675976, EBI-307352;
CC Q9BV90; Q04864-2: REL; NbExp=3; IntAct=EBI-9675976, EBI-10829018;
CC Q9BV90; Q9Y2W6: TDRKH; NbExp=3; IntAct=EBI-9675976, EBI-12842466;
CC Q9BV90; Q96N21: TEPSIN; NbExp=3; IntAct=EBI-9675976, EBI-11139477;
CC Q9BV90; Q13077: TRAF1; NbExp=3; IntAct=EBI-9675976, EBI-359224;
CC Q9BV90; Q12933: TRAF2; NbExp=3; IntAct=EBI-9675976, EBI-355744;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15146077}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-10 is the initiator.
CC {ECO:0000305}.
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DR EMBL; AK026593; BAB15505.1; -; mRNA.
DR EMBL; DQ431198; ABD95904.1; -; Genomic_DNA.
DR EMBL; AE006462; AAK61211.1; -; Genomic_DNA.
DR EMBL; BC001381; AAH01381.1; -; mRNA.
DR EMBL; BC009179; AAH09179.1; -; mRNA.
DR EMBL; BK005201; DAA05499.1; -; mRNA.
DR RefSeq; NP_078847.1; NM_024571.3.
DR AlphaFoldDB; Q9BV90; -.
DR SMR; Q9BV90; -.
DR BioGRID; 122752; 27.
DR CORUM; Q9BV90; -.
DR IntAct; Q9BV90; 17.
DR MINT; Q9BV90; -.
DR STRING; 9606.ENSP00000372482; -.
DR iPTMnet; Q9BV90; -.
DR PhosphoSitePlus; Q9BV90; -.
DR BioMuta; SNRNP25; -.
DR DMDM; 68052377; -.
DR jPOST; Q9BV90; -.
DR MassIVE; Q9BV90; -.
DR PaxDb; Q9BV90; -.
DR PeptideAtlas; Q9BV90; -.
DR PRIDE; Q9BV90; -.
DR ProteomicsDB; 79183; -.
DR Antibodypedia; 22444; 50 antibodies from 13 providers.
DR DNASU; 79622; -.
DR Ensembl; ENST00000383018.7; ENSP00000372482.3; ENSG00000161981.11.
DR GeneID; 79622; -.
DR KEGG; hsa:79622; -.
DR UCSC; uc059ofp.1; human.
DR CTD; 79622; -.
DR DisGeNET; 79622; -.
DR GeneCards; SNRNP25; -.
DR HGNC; HGNC:14161; SNRNP25.
DR HPA; ENSG00000161981; Tissue enhanced (skeletal).
DR neXtProt; NX_Q9BV90; -.
DR OpenTargets; ENSG00000161981; -.
DR PharmGKB; PA164726099; -.
DR VEuPathDB; HostDB:ENSG00000161981; -.
DR eggNOG; ENOG502RXSI; Eukaryota.
DR GeneTree; ENSGT00390000002628; -.
DR InParanoid; Q9BV90; -.
DR OMA; WRTYHLV; -.
DR OrthoDB; 1549734at2759; -.
DR PhylomeDB; Q9BV90; -.
DR TreeFam; TF329506; -.
DR PathwayCommons; Q9BV90; -.
DR Reactome; R-HSA-72165; mRNA Splicing - Minor Pathway.
DR SignaLink; Q9BV90; -.
DR BioGRID-ORCS; 79622; 764 hits in 1035 CRISPR screens.
DR ChiTaRS; SNRNP25; human.
DR GenomeRNAi; 79622; -.
DR Pharos; Q9BV90; Tdark.
DR PRO; PR:Q9BV90; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; Q9BV90; protein.
DR Bgee; ENSG00000161981; Expressed in pons and 194 other tissues.
DR ExpressionAtlas; Q9BV90; baseline and differential.
DR Genevisible; Q9BV90; HS.
DR GO; GO:0005829; C:cytosol; IDA:HPA.
DR GO; GO:0045171; C:intercellular bridge; IDA:HPA.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0005634; C:nucleus; IDA:MGI.
DR GO; GO:0005689; C:U12-type spliceosomal complex; IDA:HGNC-UCL.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IEA:InterPro.
DR GO; GO:0008380; P:RNA splicing; IC:HGNC-UCL.
DR CDD; cd17058; Ubl_SNRNP25; 1.
DR InterPro; IPR039690; SNRNP25.
DR InterPro; IPR040610; SNRNP25_ubiquitin.
DR InterPro; IPR000626; Ubiquitin-like_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR14942; PTHR14942; 1.
DR Pfam; PF18036; Ubiquitin_4; 1.
DR SUPFAM; SSF54236; SSF54236; 1.
DR PROSITE; PS50053; UBIQUITIN_2; 1.
PE 1: Evidence at protein level;
KW mRNA processing; mRNA splicing; Nucleus; Reference proteome; Spliceosome.
FT CHAIN 1..132
FT /note="U11/U12 small nuclear ribonucleoprotein 25 kDa
FT protein"
FT /id="PRO_0000114924"
FT DOMAIN 41..132
FT /note="Ubiquitin-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00214"
FT CONFLICT 106
FT /note="T -> A (in Ref. 1; BAB15505)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 132 AA; 15270 MW; FC1C3FC39611226A CRC64;
MDVFQEGLAM VVQDPLLCDL PIQVTLEEVN SQIALEYGQA MTVRVCKMDG EVMPVVVVQS
ATVLDLKKAI QRYVQLKQER EGGIQHISWS YVWRTYHLTS AGEKLTEDRK KLRDYGIRNR
DEVSFIKKLR QK
