SNR25_MOUSE
ID SNR25_MOUSE Reviewed; 123 AA.
AC Q8VIK1; Q9CX75;
DT 21-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=U11/U12 small nuclear ribonucleoprotein 25 kDa protein;
DE Short=U11/U12 snRNP 25 kDa protein;
GN Name=Snrnp25;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11157800; DOI=10.1093/hmg/10.4.371;
RA Flint J., Tufarelli C., Peden J., Clark K., Daniels R.J., Hardison R.,
RA Miller W., Philipsen S., Tan-Un K.C., McMorrow T., Frampton J., Alter B.P.,
RA Frischauf A.-M., Higgs D.R.;
RT "Comparative genome analysis delimits a chromosomal domain and identifies
RT key regulatory elements in the alpha globin cluster.";
RL Hum. Mol. Genet. 10:371-382(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Embryonic head;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP STRUCTURE BY NMR OF 32-123.
RG RIKEN structural genomics initiative (RSGI);
RT "Solution structure of mouse hypothetical gene (RIKEN cDNA 3300001G02)
RT product homologous to ubiquitin fold.";
RL Submitted (APR-2004) to the PDB data bank.
CC -!- SUBUNIT: Component of the U11/U12 snRNPs that are part of the U12-type
CC spliceosome. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
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DR EMBL; AY016021; AAL32366.1; -; Genomic_DNA.
DR EMBL; AK019452; BAB31728.1; -; mRNA.
DR EMBL; BC028766; AAH28766.1; -; mRNA.
DR CCDS; CCDS24518.1; -.
DR RefSeq; NP_084369.2; NM_030093.3.
DR PDB; 1V2Y; NMR; -; A=32-123.
DR PDBsum; 1V2Y; -.
DR AlphaFoldDB; Q8VIK1; -.
DR SMR; Q8VIK1; -.
DR STRING; 10090.ENSMUSP00000046654; -.
DR PhosphoSitePlus; Q8VIK1; -.
DR EPD; Q8VIK1; -.
DR PaxDb; Q8VIK1; -.
DR PRIDE; Q8VIK1; -.
DR ProteomicsDB; 257539; -.
DR Antibodypedia; 22444; 50 antibodies from 13 providers.
DR Ensembl; ENSMUST00000039601; ENSMUSP00000046654; ENSMUSG00000040767.
DR GeneID; 78372; -.
DR KEGG; mmu:78372; -.
DR UCSC; uc007ija.2; mouse.
DR CTD; 79622; -.
DR MGI; MGI:1925622; Snrnp25.
DR VEuPathDB; HostDB:ENSMUSG00000040767; -.
DR eggNOG; ENOG502RXSI; Eukaryota.
DR GeneTree; ENSGT00390000002628; -.
DR HOGENOM; CLU_094998_1_0_1; -.
DR InParanoid; Q8VIK1; -.
DR OMA; WRTYHLV; -.
DR OrthoDB; 1549734at2759; -.
DR PhylomeDB; Q8VIK1; -.
DR TreeFam; TF329506; -.
DR Reactome; R-MMU-72165; mRNA Splicing - Minor Pathway.
DR BioGRID-ORCS; 78372; 26 hits in 75 CRISPR screens.
DR ChiTaRS; Snrnp25; mouse.
DR EvolutionaryTrace; Q8VIK1; -.
DR PRO; PR:Q8VIK1; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q8VIK1; protein.
DR Bgee; ENSMUSG00000040767; Expressed in ileal epithelium and 254 other tissues.
DR ExpressionAtlas; Q8VIK1; baseline and differential.
DR Genevisible; Q8VIK1; MM.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0045171; C:intercellular bridge; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; ISS:MGI.
DR GO; GO:0005689; C:U12-type spliceosomal complex; ISS:HGNC-UCL.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IEA:InterPro.
DR CDD; cd17058; Ubl_SNRNP25; 1.
DR InterPro; IPR039690; SNRNP25.
DR InterPro; IPR040610; SNRNP25_ubiquitin.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR14942; PTHR14942; 1.
DR Pfam; PF18036; Ubiquitin_4; 1.
DR SUPFAM; SSF54236; SSF54236; 1.
PE 1: Evidence at protein level;
KW 3D-structure; mRNA processing; mRNA splicing; Nucleus; Reference proteome;
KW Spliceosome.
FT CHAIN 1..123
FT /note="U11/U12 small nuclear ribonucleoprotein 25 kDa
FT protein"
FT /id="PRO_0000114925"
FT DOMAIN 32..123
FT /note="Ubiquitin-like"
FT CONFLICT 121
FT /note="R -> G (in Ref. 2; BAB31728)"
FT /evidence="ECO:0000305"
FT STRAND 32..37
FT /evidence="ECO:0007829|PDB:1V2Y"
FT STRAND 39..41
FT /evidence="ECO:0007829|PDB:1V2Y"
FT STRAND 43..48
FT /evidence="ECO:0007829|PDB:1V2Y"
FT HELIX 54..71
FT /evidence="ECO:0007829|PDB:1V2Y"
FT HELIX 80..84
FT /evidence="ECO:0007829|PDB:1V2Y"
FT STRAND 87..93
FT /evidence="ECO:0007829|PDB:1V2Y"
FT STRAND 99..102
FT /evidence="ECO:0007829|PDB:1V2Y"
FT HELIX 103..105
FT /evidence="ECO:0007829|PDB:1V2Y"
FT STRAND 110..118
FT /evidence="ECO:0007829|PDB:1V2Y"
SQ SEQUENCE 123 AA; 14292 MW; EA0A5C0396B679A8 CRC64;
MVVQDPLLCD LPIQVTLEEV NSQIALEYGQ AMTVRVCKMD GEVMPVVVVQ NATVLDLKKA
IQRYVQLKQE REGGVQHISW SYVWRTYHLT SAGEKLTEDR KKLRDYGIRN RDEVSFIKKL
RQK
