ID   SNR40_BOVIN             Reviewed;         358 AA.
AC   Q2HJH6;
DT   11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=U5 small nuclear ribonucleoprotein 40 kDa protein;
DE            Short=U5 snRNP 40 kDa protein;
DE   AltName: Full=WD repeat-containing protein 57;
GN   Name=SNRNP40; Synonyms=WDR57;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Testis;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for pre-mRNA splicing as component of the activated
CC       spliceosome. Component of the U5 small nuclear ribonucleoprotein
CC       (snRNP) complex and the U4/U6-U5 tri-snRNP complex, building blocks of
CC       the spliceosome. {ECO:0000250|UniProtKB:Q96DI7}.
CC   -!- SUBUNIT: Component of the pre-catalytic and catalytic spliceosome
CC       complexes. Component of the postcatalytic spliceosome P complex. Part
CC       of the U5 snRNP complex. Interacts with PRPF8. Component of the U4/U6-
CC       U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least
CC       PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, WDR57, SNRNP40,
CC       DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39.
CC       {ECO:0000250|UniProtKB:Q96DI7}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q96DI7}.
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DR   EMBL; BC105383; AAI05384.1; -; mRNA.
DR   RefSeq; NP_001039847.1; NM_001046382.2.
DR   AlphaFoldDB; Q2HJH6; -.
DR   SMR; Q2HJH6; -.
DR   STRING; 9913.ENSBTAP00000022372; -.
DR   PaxDb; Q2HJH6; -.
DR   GeneID; 534645; -.
DR   KEGG; bta:534645; -.
DR   CTD; 9410; -.
DR   eggNOG; KOG0265; Eukaryota.
DR   InParanoid; Q2HJH6; -.
DR   OrthoDB; 1133270at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF00400; WD40; 7.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 5.
DR   PROSITE; PS50082; WD_REPEATS_2; 7.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Isopeptide bond; Methylation; mRNA processing; mRNA splicing; Nucleus;
KW   Reference proteome; Repeat; Spliceosome; Ubl conjugation; WD repeat.
FT   CHAIN           1..358
FT                   /note="U5 small nuclear ribonucleoprotein 40 kDa protein"
FT                   /id="PRO_0000246075"
FT   REPEAT          65..104
FT                   /note="WD 1"
FT   REPEAT          108..147
FT                   /note="WD 2"
FT   REPEAT          150..190
FT                   /note="WD 3"
FT   REPEAT          192..231
FT                   /note="WD 4"
FT   REPEAT          234..273
FT                   /note="WD 5"
FT   REPEAT          284..323
FT                   /note="WD 6"
FT   REPEAT          326..358
FT                   /note="WD 7"
FT   MOD_RES         21
FT                   /note="Asymmetric dimethylarginine"
FT                   /evidence="ECO:0000250|UniProtKB:Q6PE01"
FT   CROSSLNK        18
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:Q96DI7"
FT   CROSSLNK        271
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:Q96DI7"
SQ   SEQUENCE   358 AA;  39380 MW;  ADF79EFE0B0A5F26 CRC64;
     MIEQQKRKGP ELPLVPVKRQ RHELLLGAAG SGPGAGQQQA APGALLQAGP PRCSSLQAPI
     MLLSGHEGEV YCCKFHPNGS TLASAGFDRL ILLWNVYGDC DNYATLKGHS GAVMELHYNT
     DGSMLFSAST DKTVAVWDSE TGERVKRLKG HTSFVNSCYP ARRGPQLVCT GSDDGTVKLW
     DIRKKAAIQT FQNTYQVLAV TFNDTSDQII SGGIDNDIKV WDLRQNKLTY TMRGHADSVT
     GLSLSSEGSY LLSNAMDNTV RVWDVRPFAP KERCVRIFQG NVHNFEKNLL RCSWSPDGSK
     IAAGSADRFV YVWDTTSRRI LYKLPGHAGS INEVAFHPDE PIILSASSDK RLYMGEIQ