SNR40_DICDI
ID SNR40_DICDI Reviewed; 355 AA.
AC Q55AR8; Q86HI6;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 102.
DE RecName: Full=U5 small nuclear ribonucleoprotein 40 kDa protein;
DE Short=U5 snRNP 40 kDa protein;
DE AltName: Full=WD repeat-containing protein 57 homolog;
GN Name=snrnp40; Synonyms=wdr57; ORFNames=DDB_G0271788;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Required for pre-mRNA splicing as component of the activated
CC spliceosome. Component of the U5 small nuclear ribonucleoprotein
CC (snRNP) complex and the U4/U6-U5 tri-snRNP complex, building blocks of
CC the spliceosome. {ECO:0000250|UniProtKB:Q96DI7}.
CC -!- SUBUNIT: Component of the pre-catalytic and catalytic spliceosome
CC complexes. Component of the postcatalytic spliceosome P complex. Part
CC of the U5 snRNP complex. Component of the U4/U6-U5 tri-snRNP complex.
CC {ECO:0000250|UniProtKB:Q96DI7}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q96DI7}.
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DR EMBL; AAFI02000006; EAL71584.1; -; Genomic_DNA.
DR RefSeq; XP_645454.1; XM_640362.1.
DR AlphaFoldDB; Q55AR8; -.
DR SMR; Q55AR8; -.
DR STRING; 44689.DDB0233518; -.
DR PaxDb; Q55AR8; -.
DR EnsemblProtists; EAL71584; EAL71584; DDB_G0271788.
DR GeneID; 8618082; -.
DR KEGG; ddi:DDB_G0271788; -.
DR dictyBase; DDB_G0271788; wdr57.
DR eggNOG; KOG0265; Eukaryota.
DR HOGENOM; CLU_000288_57_2_1; -.
DR InParanoid; Q55AR8; -.
DR OMA; WDLRKNA; -.
DR PhylomeDB; Q55AR8; -.
DR Reactome; R-DDI-72163; mRNA Splicing - Major Pathway.
DR Reactome; R-DDI-72165; mRNA Splicing - Minor Pathway.
DR PRO; PR:Q55AR8; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0071013; C:catalytic step 2 spliceosome; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; ISS:dictyBase.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF00400; WD40; 6.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 3.
DR PROSITE; PS50082; WD_REPEATS_2; 5.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW mRNA processing; mRNA splicing; Nucleus; Reference proteome; Repeat;
KW Spliceosome; WD repeat.
FT CHAIN 1..355
FT /note="U5 small nuclear ribonucleoprotein 40 kDa protein"
FT /id="PRO_0000330843"
FT REPEAT 60..99
FT /note="WD 1"
FT REPEAT 103..142
FT /note="WD 2"
FT REPEAT 145..185
FT /note="WD 3"
FT REPEAT 187..226
FT /note="WD 4"
FT REPEAT 230..269
FT /note="WD 5"
FT REPEAT 280..319
FT /note="WD 6"
FT REPEAT 322..355
FT /note="WD 7"
SQ SEQUENCE 355 AA; 39502 MW; C8C4DF6544A14966 CRC64;
MENKRKQKDE IVLVNGSNDT TPNKKQKNEL QVVSSGGGRE IILGTERTSK LEHPIMQLIG
HKGEIYSCKF NSYGTALASG GSDKEIFLWN VYGECINYSV LKGHKGTILE LHWSTDSNEI
YTACTDKSIG VWDSNKGELI KRIREHSGVV NSCCPARRGP PLVASGSDDR SARIFDTRSK
GSTHLFQHKY PVTSVCFSDA SDQLITGGID NVIRVWDIRN QEDPLYTLAS HQDTITSTSV
SKDGAYLLSN SMDNSCKIWD IRPYAPPNRN IKTFNGAQNN FEKNLIKSSW SIDGRRIGCG
SSDRQVYIWD TNTKQLQYCL PGHSGTVNEV TFHPNEPIIA SCSSDKTIYL GEIKP
