ID   SNR40_PONAB             Reviewed;         357 AA.
AC   Q5RF51;
DT   07-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=U5 small nuclear ribonucleoprotein 40 kDa protein;
DE            Short=U5 snRNP 40 kDa protein;
DE   AltName: Full=WD repeat-containing protein 57;
GN   Name=SNRNP40; Synonyms=WDR57;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for pre-mRNA splicing as component of the activated
CC       spliceosome. Component of the U5 small nuclear ribonucleoprotein
CC       (snRNP) complex and the U4/U6-U5 tri-snRNP complex, building blocks of
CC       the spliceosome. {ECO:0000250|UniProtKB:Q96DI7}.
CC   -!- SUBUNIT: Component of the pre-catalytic and catalytic spliceosome
CC       complexes. Component of the postcatalytic spliceosome P complex. Part
CC       of the U5 snRNP complex. Interacts with PRPF8. Component of the U4/U6-
CC       U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least
CC       PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, WDR57, SNRNP40,
CC       DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39.
CC       {ECO:0000250|UniProtKB:Q96DI7}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q96DI7}.
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DR   EMBL; CR857310; CAH89606.1; -; mRNA.
DR   RefSeq; NP_001124715.1; NM_001131243.1.
DR   AlphaFoldDB; Q5RF51; -.
DR   SMR; Q5RF51; -.
DR   STRING; 9601.ENSPPYP00000001868; -.
DR   GeneID; 100171563; -.
DR   KEGG; pon:100171563; -.
DR   CTD; 9410; -.
DR   eggNOG; KOG0265; Eukaryota.
DR   InParanoid; Q5RF51; -.
DR   OrthoDB; 1133270at2759; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF00400; WD40; 7.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 5.
DR   PROSITE; PS50082; WD_REPEATS_2; 7.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Isopeptide bond; Methylation; mRNA processing; mRNA splicing; Nucleus;
KW   Reference proteome; Repeat; Spliceosome; Ubl conjugation; WD repeat.
FT   CHAIN           1..357
FT                   /note="U5 small nuclear ribonucleoprotein 40 kDa protein"
FT                   /id="PRO_0000051419"
FT   REPEAT          64..103
FT                   /note="WD 1"
FT   REPEAT          107..146
FT                   /note="WD 2"
FT   REPEAT          149..189
FT                   /note="WD 3"
FT   REPEAT          191..230
FT                   /note="WD 4"
FT   REPEAT          233..272
FT                   /note="WD 5"
FT   REPEAT          283..322
FT                   /note="WD 6"
FT   REPEAT          325..357
FT                   /note="WD 7"
FT   MOD_RES         21
FT                   /note="Asymmetric dimethylarginine"
FT                   /evidence="ECO:0000250|UniProtKB:Q6PE01"
FT   CROSSLNK        18
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:Q96DI7"
FT   CROSSLNK        270
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:Q96DI7"
SQ   SEQUENCE   357 AA;  39158 MW;  F849C91B1334F911 CRC64;
     MIEQQKRKGP ELPLVPVKRQ RHELLLGAGS GPGAGQQQAT PGALLQAGPP RCSSLQAPIM
     LLSGHEGEVY CCKFHPNGST LASAGFDRLI LLWNVYGDCG NYATLKGYSG AVMELHYNTD
     GSMLFSASTD KTVAVWDSET GERVKRLKGH TSFVNSCYPA RRGPQLVCTG SDDGTVKLWD
     IRKKAAIQTF QNTYQVLAVT FNDTSDQIIS GGIDNDIKVW DLRQNKLTYT MRGHADSVTG
     LSLSSEGSYL LSNAMDNTVR VWDVRPFAPK ERCVKIFQGN VHNFEKNLLR CSWSPDGSKI
     AAGSADRSVC VWDTTSRRIL YKLPGHAGSI NEVAFHPDEP IIISASSDKR LYMGEIQ