SNR48_MOUSE
ID SNR48_MOUSE Reviewed; 337 AA.
AC Q9D361; Q8BIU0; Q8BJ30; Q8CFF6; Q8VDQ5; Q9CSG3; Q9CVM5;
DT 19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2005, sequence version 2.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=U11/U12 small nuclear ribonucleoprotein 48 kDa protein;
DE Short=U11/U12 snRNP 48 kDa protein;
GN Name=Snrnp48;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
RC STRAIN=C57BL/6J; TISSUE=Cerebellum, Embryo, Ovary, and Pancreas;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=Czech II; TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Likely involved in U12-type 5' splice site recognition.
CC {ECO:0000250}.
CC -!- SUBUNIT: Component of the U11/U12 snRNPs that are part of the U12-type
CC spliceosome. Not found in the major spliceosome (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q9D361-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9D361-2; Sequence=VSP_014644;
CC Name=3;
CC IsoId=Q9D361-3; Sequence=VSP_014642, VSP_014643;
CC -!- DOMAIN: The CHHC region interacts with the 5' splice site of the U12-
CC type Intron. {ECO:0000250}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH37073.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
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DR EMBL; AK007431; BAB25034.3; -; mRNA.
DR EMBL; AK012916; BAB28547.1; -; mRNA.
DR EMBL; AK018315; BAB31160.1; -; mRNA.
DR EMBL; AK087789; BAC40003.1; -; mRNA.
DR EMBL; BC021443; AAH21443.1; -; mRNA.
DR EMBL; BC037073; AAH37073.1; ALT_SEQ; mRNA.
DR CCDS; CCDS36635.1; -. [Q9D361-1]
DR RefSeq; NP_080658.2; NM_026382.2. [Q9D361-1]
DR AlphaFoldDB; Q9D361; -.
DR SMR; Q9D361; -.
DR BioGRID; 212448; 2.
DR STRING; 10090.ENSMUSP00000089230; -.
DR iPTMnet; Q9D361; -.
DR PhosphoSitePlus; Q9D361; -.
DR EPD; Q9D361; -.
DR MaxQB; Q9D361; -.
DR PaxDb; Q9D361; -.
DR PRIDE; Q9D361; -.
DR ProteomicsDB; 257280; -. [Q9D361-1]
DR ProteomicsDB; 257281; -. [Q9D361-2]
DR ProteomicsDB; 257282; -. [Q9D361-3]
DR Antibodypedia; 24691; 99 antibodies from 16 providers.
DR DNASU; 67797; -.
DR Ensembl; ENSMUST00000091641; ENSMUSP00000089230; ENSMUSG00000021431. [Q9D361-1]
DR GeneID; 67797; -.
DR KEGG; mmu:67797; -.
DR UCSC; uc007qdm.1; mouse. [Q9D361-3]
DR UCSC; uc007qdo.1; mouse. [Q9D361-1]
DR CTD; 154007; -.
DR MGI; MGI:1915047; Snrnp48.
DR VEuPathDB; HostDB:ENSMUSG00000021431; -.
DR eggNOG; ENOG502QW2V; Eukaryota.
DR GeneTree; ENSGT00390000004886; -.
DR HOGENOM; CLU_072333_0_0_1; -.
DR InParanoid; Q9D361; -.
DR OMA; WQGQYSG; -.
DR OrthoDB; 1626841at2759; -.
DR PhylomeDB; Q9D361; -.
DR TreeFam; TF332204; -.
DR Reactome; R-MMU-72165; mRNA Splicing - Minor Pathway.
DR BioGRID-ORCS; 67797; 13 hits in 72 CRISPR screens.
DR ChiTaRS; Snrnp48; mouse.
DR PRO; PR:Q9D361; -.
DR Proteomes; UP000000589; Chromosome 13.
DR RNAct; Q9D361; protein.
DR Bgee; ENSMUSG00000021431; Expressed in urogenital fold and 253 other tissues.
DR ExpressionAtlas; Q9D361; baseline and differential.
DR Genevisible; Q9D361; MM.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005689; C:U12-type spliceosomal complex; ISS:HGNC-UCL.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR InterPro; IPR032845; Snrnp48.
DR InterPro; IPR022776; TRM13/UPF0224_CHHC_Znf_dom.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR PANTHER; PTHR21402:SF10; PTHR21402:SF10; 2.
DR Pfam; PF05253; zf-U11-48K; 1.
DR SUPFAM; SSF57667; SSF57667; 1.
DR PROSITE; PS51800; ZF_CHHC_U11_48K; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Isopeptide bond; Metal-binding; mRNA processing;
KW mRNA splicing; Nucleus; Reference proteome; Spliceosome; Ubl conjugation;
KW Zinc; Zinc-finger.
FT CHAIN 1..337
FT /note="U11/U12 small nuclear ribonucleoprotein 48 kDa
FT protein"
FT /id="PRO_0000089545"
FT ZN_FING 55..82
FT /note="CHHC U11-48K-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01141"
FT REGION 255..337
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 255..278
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 297..313
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 323..337
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 58
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01141"
FT BINDING 64
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01141"
FT BINDING 74
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01141"
FT BINDING 78
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01141"
FT CROSSLNK 87
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q6IEG0"
FT CROSSLNK 104
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q6IEG0"
FT VAR_SEQ 136..142
FT /note="RMYSSVP -> SKCCSFS (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_014642"
FT VAR_SEQ 143..337
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_014643"
FT VAR_SEQ 169..231
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_014644"
FT CONFLICT 11..13
FT /note="RRR -> GGW (in Ref. 1; BAB25034)"
FT /evidence="ECO:0000305"
FT CONFLICT 93
FT /note="M -> R (in Ref. 1; BAC40003)"
FT /evidence="ECO:0000305"
FT CONFLICT 159
FT /note="T -> M (in Ref. 2; AAH21443)"
FT /evidence="ECO:0000305"
FT CONFLICT 221
FT /note="R -> G (in Ref. 1; BAB25034)"
FT /evidence="ECO:0000305"
FT CONFLICT 231
FT /note="H -> R (in Ref. 1; BAB31160)"
FT /evidence="ECO:0000305"
FT CONFLICT 293
FT /note="S -> L (in Ref. 1; BAB25034)"
FT /evidence="ECO:0000305"
FT CONFLICT 297
FT /note="R -> G (in Ref. 1; BAB25034)"
FT /evidence="ECO:0000305"
FT CONFLICT 302..303
FT /note="SP -> AT (in Ref. 1; BAB25034)"
FT /evidence="ECO:0000305"
FT CONFLICT 306
FT /note="R -> Q (in Ref. 2; AAH37073)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 337 AA; 39453 MW; 03BE47FE28F6E57D CRC64;
METEPPPLEE RRRLQEELSE FVESCCRTLE EVTASLGWSL DQLDPGDEAE AEDEIAICPY
DSNHRMPKSS LTKHMESCRL RKLGYTKEEE NEMYNPTFFY ENLKIPSVTL NKDSQFQIIK
QARTTAGKDG DCYSQRMYSS VPVEVPLNHK RSVCDLTQTD RLALYDFVIE ETKKKRSGPQ
VIENDSDLFV DLAAKVNQDN SRKSPKSYLE ILAEVRDYKR RRQSYRAKNV HITKKSYTEV
IRDVIKVHME ELSSHWQEEQ GRAGDAAEKN EERRSASVDS RQSGGSYLDV ESSRHRRARS
RSPHKRKRNK DKSSESRRRK ERDGERHHSH KRRKQKI
