SNTAN_HUMAN
ID SNTAN_HUMAN Reviewed; 147 AA.
AC A6NMZ2; B7FF65;
DT 01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-JUL-2007, sequence version 1.
DT 03-AUG-2022, entry version 97.
DE RecName: Full=Sentan;
DE AltName: Full=Protein S100-A1-like;
DE AltName: Full=S100 calcium-binding protein A1-like;
GN Name=SNTN; Synonyms=S100A1L;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Nasopharynx;
RX PubMed=15289893;
RA Liu X.-Q., Zhou Y., Zhang L.-J., Xu H., Chen H.-K., Pan Z.-G., Zeng Y.-X.;
RT "Transcriptional gene expression profile of human nasopharynx.";
RL Int. J. Mol. Med. 14:409-420(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16641997; DOI=10.1038/nature04728;
RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT "The DNA sequence, annotation and analysis of human chromosome 3.";
RL Nature 440:1194-1198(2006).
RN [3]
RP IDENTIFICATION.
RX PubMed=18829862; DOI=10.1091/mbc.e08-07-0691;
RA Kubo A., Yuba-Kubo A., Tsukita S., Tsukita S., Amagai M.;
RT "Sentan: a novel specific component of the apical structure of vertebrate
RT motile cilia.";
RL Mol. Biol. Cell 19:5338-5346(2008).
CC -!- FUNCTION: May be a component of the linker structure that bridges the
CC ciliary membrane and peripheral singlet microtubules. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000250}.
CC Note=Expressed exclusively at the cilium tip where it localizes between
CC the cell membrane and peripheral A-subfibers. {ECO:0000250}.
CC -!- MISCELLANEOUS: 'Sentan' means 'tip' in Japanese.
CC -!- SIMILARITY: Belongs to the S-100 family. {ECO:0000305}.
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DR EMBL; CD690073; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AC136289; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BR000723; FAA00429.1; -; mRNA.
DR CCDS; CCDS33779.1; -.
DR RefSeq; NP_001074006.1; NM_001080537.1.
DR AlphaFoldDB; A6NMZ2; -.
DR SMR; A6NMZ2; -.
DR STRING; 9606.ENSP00000341442; -.
DR iPTMnet; A6NMZ2; -.
DR PhosphoSitePlus; A6NMZ2; -.
DR BioMuta; SNTN; -.
DR MassIVE; A6NMZ2; -.
DR PaxDb; A6NMZ2; -.
DR PeptideAtlas; A6NMZ2; -.
DR PRIDE; A6NMZ2; -.
DR ProteomicsDB; 1571; -.
DR Antibodypedia; 50719; 15 antibodies from 5 providers.
DR DNASU; 132203; -.
DR Ensembl; ENST00000343837.8; ENSP00000341442.3; ENSG00000188817.8.
DR GeneID; 132203; -.
DR KEGG; hsa:132203; -.
DR MANE-Select; ENST00000343837.8; ENSP00000341442.3; NM_001080537.2; NP_001074006.1.
DR UCSC; uc003dlr.4; human.
DR CTD; 132203; -.
DR DisGeNET; 132203; -.
DR GeneCards; SNTN; -.
DR HGNC; HGNC:33706; SNTN.
DR HPA; ENSG00000188817; Tissue enriched (fallopian).
DR MIM; 617832; gene.
DR neXtProt; NX_A6NMZ2; -.
DR OpenTargets; ENSG00000188817; -.
DR PharmGKB; PA164726205; -.
DR VEuPathDB; HostDB:ENSG00000188817; -.
DR eggNOG; ENOG502S6AH; Eukaryota.
DR GeneTree; ENSGT00390000003322; -.
DR InParanoid; A6NMZ2; -.
DR OMA; CTHSTQD; -.
DR OrthoDB; 1529608at2759; -.
DR PhylomeDB; A6NMZ2; -.
DR TreeFam; TF335855; -.
DR PathwayCommons; A6NMZ2; -.
DR BioGRID-ORCS; 132203; 16 hits in 1062 CRISPR screens.
DR ChiTaRS; SNTN; human.
DR GenomeRNAi; 132203; -.
DR Pharos; A6NMZ2; Tdark.
DR PRO; PR:A6NMZ2; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; A6NMZ2; protein.
DR Bgee; ENSG00000188817; Expressed in bronchial epithelial cell and 95 other tissues.
DR ExpressionAtlas; A6NMZ2; baseline and differential.
DR Genevisible; A6NMZ2; HS.
DR GO; GO:0005929; C:cilium; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR GO; GO:0048306; F:calcium-dependent protein binding; IBA:GO_Central.
DR GO; GO:0046914; F:transition metal ion binding; IEA:InterPro.
DR CDD; cd00213; S-100; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR034325; S-100_dom.
DR InterPro; IPR013787; S100_Ca-bd_sub.
DR InterPro; IPR026790; Sentan.
DR PANTHER; PTHR11639:SF134; PTHR11639:SF134; 1.
DR SMART; SM01394; S_100; 1.
DR SUPFAM; SSF47473; SSF47473; 1.
PE 2: Evidence at transcript level;
KW Cell projection; Cilium; Reference proteome.
FT CHAIN 1..147
FT /note="Sentan"
FT /id="PRO_0000342516"
FT REGION 1..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 147 AA; 16468 MW; F1813E10E7BA5D13 CRC64;
MGGCMHSTQD KSLHLEGDPN PSAAPTSTCA PRKMPKRISI SKQLASVKAL RKCSDLEKAI
ATTALIFRNS SDSDGKLEKA IAKDLLQTQF RNFAEGQETK PKYREILSEL DEHTENKLDF
EDFMILLLSI TVMSDLLQNI RNVKIMK
