SNTAN_MOUSE
ID SNTAN_MOUSE Reviewed; 147 AA.
AC Q8C9X1; B7FF66;
DT 01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Sentan;
DE AltName: Full=Protein S100-A1-like;
DE AltName: Full=S100 calcium-binding protein A1-like;
GN Name=Sntn; Synonyms=S100a1l;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND
RP DEVELOPMENTAL STAGE.
RX PubMed=18829862; DOI=10.1091/mbc.e08-07-0691;
RA Kubo A., Yuba-Kubo A., Tsukita S., Tsukita S., Amagai M.;
RT "Sentan: a novel specific component of the apical structure of vertebrate
RT motile cilia.";
RL Mol. Biol. Cell 19:5338-5346(2008).
CC -!- FUNCTION: May be a component of the linker structure that bridges the
CC ciliary membrane and peripheral singlet microtubules.
CC {ECO:0000269|PubMed:18829862}.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium
CC {ECO:0000269|PubMed:18829862}. Note=Expressed exclusively at the cilium
CC tip where it localizes between the cell membrane and peripheral A-
CC subfibers.
CC -!- TISSUE SPECIFICITY: Expressed exclusively in ciliated epithelial cells.
CC Detected in ciliated epithelium of trachea and oviduct (at protein
CC level). {ECO:0000269|PubMed:18829862}.
CC -!- DEVELOPMENTAL STAGE: Expression gradually increases during in vitro
CC ciliogenesis. {ECO:0000269|PubMed:18829862}.
CC -!- MISCELLANEOUS: 'Sentan' means 'tip' in Japanese.
CC -!- SIMILARITY: Belongs to the S-100 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK040281; BAC30559.1; -; mRNA.
DR EMBL; BC126945; AAI26946.1; -; mRNA.
DR EMBL; BR000724; FAA00430.1; -; mRNA.
DR CCDS; CCDS26822.1; -.
DR RefSeq; NP_808292.1; NM_177624.3.
DR AlphaFoldDB; Q8C9X1; -.
DR SMR; Q8C9X1; -.
DR STRING; 10090.ENSMUSP00000062092; -.
DR PhosphoSitePlus; Q8C9X1; -.
DR MaxQB; Q8C9X1; -.
DR PaxDb; Q8C9X1; -.
DR PRIDE; Q8C9X1; -.
DR ProteomicsDB; 261535; -.
DR Antibodypedia; 50719; 15 antibodies from 5 providers.
DR DNASU; 218739; -.
DR Ensembl; ENSMUST00000061045; ENSMUSP00000062092; ENSMUSG00000044772.
DR GeneID; 218739; -.
DR KEGG; mmu:218739; -.
DR UCSC; uc007sgc.1; mouse.
DR CTD; 132203; -.
DR MGI; MGI:3045373; Sntn.
DR VEuPathDB; HostDB:ENSMUSG00000044772; -.
DR eggNOG; ENOG502S6AH; Eukaryota.
DR GeneTree; ENSGT00390000003322; -.
DR HOGENOM; CLU_148109_0_0_1; -.
DR InParanoid; Q8C9X1; -.
DR OMA; CTHSTQD; -.
DR OrthoDB; 1529608at2759; -.
DR PhylomeDB; Q8C9X1; -.
DR TreeFam; TF335855; -.
DR BioGRID-ORCS; 218739; 2 hits in 74 CRISPR screens.
DR PRO; PR:Q8C9X1; -.
DR Proteomes; UP000000589; Chromosome 14.
DR RNAct; Q8C9X1; protein.
DR Bgee; ENSMUSG00000044772; Expressed in lung epithelium and 9 other tissues.
DR GO; GO:0005929; C:cilium; IDA:MGI.
DR GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR GO; GO:0048306; F:calcium-dependent protein binding; IBA:GO_Central.
DR GO; GO:0046914; F:transition metal ion binding; IEA:InterPro.
DR CDD; cd00213; S-100; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR034325; S-100_dom.
DR InterPro; IPR013787; S100_Ca-bd_sub.
DR InterPro; IPR026790; Sentan.
DR PANTHER; PTHR11639:SF134; PTHR11639:SF134; 1.
DR Pfam; PF01023; S_100; 1.
DR SMART; SM01394; S_100; 1.
DR SUPFAM; SSF47473; SSF47473; 1.
PE 1: Evidence at protein level;
KW Cell projection; Cilium; Reference proteome.
FT CHAIN 1..147
FT /note="Sentan"
FT /id="PRO_0000342517"
FT REGION 1..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 147 AA; 16415 MW; F1CE14DBFE826D59 CRC64;
MGGCMHSTWD HALHSRGEPR PSEAPASISA PSKMPKSVSI SKQLASIKAL KKGSDLEKAI
ATIALVFRNA SDPDGKLGKA TAKKLLQTQF KKFTEREETK PKYQDILSEL DEHTENKLDF
EDFVILLLSL AIMSDLLRNM WNENTMK
