ID   SNTG2_MOUSE             Reviewed;         539 AA.
AC   Q925E0; B2RSQ0;
DT   10-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 135.
DE   RecName: Full=Gamma-2-syntrophin;
DE            Short=G2SYN;
DE   AltName: Full=Syntrophin-5;
DE            Short=SYN5;
GN   Name=Sntg2;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=C57BL/6J;
RA   Alessi A., Adams M.E., Froehner S.C.;
RT   "Cloning and characterization of mouse gamma syntrophins.";
RL   Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Adapter protein that binds to and probably organizes the
CC       subcellular localization of a variety of proteins. May link various
CC       receptors to the actin cytoskeleton and the dystrophin glycoprotein
CC       complex (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with the dystrophin protein DMD and related proteins
CC       DTNA and DTNB. {ECO:0000250}.
CC   -!- INTERACTION:
CC       Q925E0; P25100: ADRA1D; Xeno; NbExp=2; IntAct=EBI-8521556, EBI-489993;
CC   -!- SUBCELLULAR LOCATION: Cell membrane, sarcolemma; Peripheral membrane
CC       protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Note=In skeletal
CC       muscle, it localizes at the cytoplasmic side of the sarcolemmal
CC       membrane.
CC   -!- DOMAIN: The association with dystrophin or related proteins probably
CC       leaves the PDZ domain available to recruit proteins to the membrane.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the syntrophin family. {ECO:0000305}.
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DR   EMBL; AF367760; AAK53400.1; -; mRNA.
DR   EMBL; BC138956; AAI38957.1; -; mRNA.
DR   CCDS; CCDS25858.1; -.
DR   RefSeq; NP_766539.2; NM_172951.3.
DR   AlphaFoldDB; Q925E0; -.
DR   SMR; Q925E0; -.
DR   BioGRID; 234517; 5.
DR   IntAct; Q925E0; 3.
DR   MINT; Q925E0; -.
DR   STRING; 10090.ENSMUSP00000021004; -.
DR   iPTMnet; Q925E0; -.
DR   PhosphoSitePlus; Q925E0; -.
DR   MaxQB; Q925E0; -.
DR   PaxDb; Q925E0; -.
DR   PRIDE; Q925E0; -.
DR   ProteomicsDB; 261537; -.
DR   Antibodypedia; 26199; 80 antibodies from 21 providers.
DR   DNASU; 268534; -.
DR   Ensembl; ENSMUST00000021004; ENSMUSP00000021004; ENSMUSG00000020672.
DR   GeneID; 268534; -.
DR   KEGG; mmu:268534; -.
DR   UCSC; uc007ngr.2; mouse.
DR   CTD; 54221; -.
DR   MGI; MGI:1919541; Sntg2.
DR   VEuPathDB; HostDB:ENSMUSG00000020672; -.
DR   eggNOG; KOG3549; Eukaryota.
DR   GeneTree; ENSGT00950000182863; -.
DR   HOGENOM; CLU_039445_0_0_1; -.
DR   InParanoid; Q925E0; -.
DR   OMA; NKYCSSD; -.
DR   OrthoDB; 1103724at2759; -.
DR   PhylomeDB; Q925E0; -.
DR   TreeFam; TF317932; -.
DR   BioGRID-ORCS; 268534; 1 hit in 71 CRISPR screens.
DR   ChiTaRS; Sntg2; mouse.
DR   PRO; PR:Q925E0; -.
DR   Proteomes; UP000000589; Chromosome 12.
DR   RNAct; Q925E0; protein.
DR   Bgee; ENSMUSG00000020672; Expressed in retinal neural layer and 109 other tissues.
DR   ExpressionAtlas; Q925E0; baseline and differential.
DR   Genevisible; Q925E0; MM.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0016010; C:dystrophin-associated glycoprotein complex; IBA:GO_Central.
DR   GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR   GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR   GO; GO:0042383; C:sarcolemma; IEA:UniProtKB-SubCell.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   GO; GO:0097109; F:neuroligin family protein binding; ISO:MGI.
DR   GO; GO:0030165; F:PDZ domain binding; ISO:MGI.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   Gene3D; 2.30.29.30; -; 1.
DR   Gene3D; 2.30.42.10; -; 1.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR015482; Syntrophin.
DR   PANTHER; PTHR10554; PTHR10554; 1.
DR   Pfam; PF00595; PDZ; 1.
DR   SMART; SM00228; PDZ; 1.
DR   SUPFAM; SSF50156; SSF50156; 1.
DR   PROSITE; PS50106; PDZ; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   1: Evidence at protein level;
KW   Actin-binding; Cell membrane; Cytoplasm; Cytoskeleton; Membrane;
KW   Reference proteome.
FT   CHAIN           1..539
FT                   /note="Gamma-2-syntrophin"
FT                   /id="PRO_0000184016"
FT   DOMAIN          73..156
FT                   /note="PDZ"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00143"
FT   DOMAIN          296..421
FT                   /note="PH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
SQ   SEQUENCE   539 AA;  59598 MW;  4DB2A0916336D379 CRC64;
     MSAEGSQSLA APRGRPSHLL VPARTKTALA LLYDEGLENA YDVRLKLTKE VLTIQKQDVV
     CIGGAPPGAN HRTVTLRRQP VGGLGLSIKG GAEHGVPVVI SKIFKDQAAD QTEMLFIGDA
     VLQVNGINVE NATHEEVVHL LRNAGDDVTI TVEYLREAPS FLKLPLGSPG PSSDHSSRAS
     SPLFDSGLHL NGHCSHTAPS SPSSPIANEP KYEKRWLDTL SVPLSMARIS RYKAGTEKLR
     SSALEVLALD GASTGVLQFS TAQDCADWLR SISTNISDLT LQHMKMANKC CSPCDQVVHM
     GWVNERLQGA DNSQNFRPKF LALRGSSFYI FGAPPVSTLD WGRAERAYNL CEVLFKVHKF
     WLSDNYWLQA NLYLGLQDFD CEDPRSYCFS VLANHGKSHI FSVELGSELA VWEKAFQRAT
     FMEVQRTGSK TYLCSWQGET LCFTVDFALG FTCFDGKTKN VLWRFKFSQL KGSSDDGKTR
     VKLLFQNLDT KQIETKELEF QDLTAVLHCI HSFIAAKVAS LDPVFMDSQS MARRYLCSS