ID   SNU23_YEAST             Reviewed;         194 AA.
AC   Q12368; D6VRQ2;
DT   18-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 153.
DE   RecName: Full=23 kDa U4/U6.U5 small nuclear ribonucleoprotein component;
GN   Name=SNU23; OrderedLocusNames=YDL098C; ORFNames=D2378;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 96604 / S288c / FY1679;
RX   PubMed=8923743;
RX   DOI=10.1002/(sici)1097-0061(199610)12:13%3c1377::aid-yea35%3e3.0.co;2-r;
RA   Boskovic J., Soler-Mira A., Garcia-Cantalejo J.M., Ballesta J.P.G.,
RA   Jimenez A., Remacha M.A.;
RT   "The sequence of a 16,691 bp segment of Saccharomyces cerevisiae chromosome
RT   IV identifies the DUN1, PMT1, PMT5, SRP14 and DPR1 genes, and five new open
RT   reading frames.";
RL   Yeast 12:1377-1384(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=9169867;
RA   Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G.,
RA   Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C.,
RA   Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F.,
RA   Delaveau T., del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M.,
RA   Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T.,
RA   Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C.,
RA   Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S.,
RA   Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L.,
RA   Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H.,
RA   Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M.,
RA   Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M.,
RA   Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A.,
RA   Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G.,
RA   Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E.,
RA   Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S.,
RA   Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D.,
RA   Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V.,
RA   Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E.,
RA   Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M.,
RA   Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D.,
RA   Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X.,
RA   Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A.,
RA   Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R.,
RA   Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T.,
RA   Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L.,
RA   Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E.,
RA   Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L.,
RA   Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M.,
RA   Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K.,
RA   Mewes H.-W., Zollner A., Zaccaria P.;
RT   "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.";
RL   Nature 387:75-78(1997).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [4]
RP   SUBUNIT, IDENTIFICATION IN THE U4/U5/U6 TRI-SNRNP COMPLEX, AND
RP   IDENTIFICATION BY MASS SPECTROMETRY.
RX   PubMed=10449419; DOI=10.1093/emboj/18.16.4535;
RA   Gottschalk A., Neubauer G., Banroques J., Mann M., Luehrmann R.,
RA   Fabrizio P.;
RT   "Identification by mass spectrometry and functional analysis of novel
RT   proteins of the yeast [U4/U6.U5] tri-snRNP.";
RL   EMBO J. 18:4535-4548(1999).
RN   [5]
RP   IDENTIFICATION IN U4/U6.U5 TRI-SNRNP COMPLEX, AND IDENTIFICATION BY MASS
RP   SPECTROMETRY.
RX   PubMed=10377396; DOI=10.1073/pnas.96.13.7226;
RA   Stevens S.W., Abelson J.;
RT   "Purification of the yeast U4/U6.U5 small nuclear ribonucleoprotein
RT   particle and identification of its proteins.";
RL   Proc. Natl. Acad. Sci. U.S.A. 96:7226-7231(1999).
RN   [6]
RP   IDENTIFICATION IN U1.U2.U4/U6.U5 PENTA-SNRNP COMPLEX, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY.
RX   PubMed=11804584; DOI=10.1016/s1097-2765(02)00436-7;
RA   Stevens S.W., Ryan D.E., Ge H.Y., Moore R.E., Young M.K., Lee T.D.,
RA   Abelson J.;
RT   "Composition and functional characterization of the yeast spliceosomal
RT   penta-snRNP.";
RL   Mol. Cell 9:31-44(2002).
RN   [7]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=14562095; DOI=10.1038/nature02026;
RA   Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA   Weissman J.S., O'Shea E.K.;
RT   "Global analysis of protein localization in budding yeast.";
RL   Nature 425:686-691(2003).
RN   [8]
RP   LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX   PubMed=14562106; DOI=10.1038/nature02046;
RA   Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA   O'Shea E.K., Weissman J.S.;
RT   "Global analysis of protein expression in yeast.";
RL   Nature 425:737-741(2003).
CC   -!- FUNCTION: Participates in pre-mRNA splicing. Part of the U4/U5/U6 tri-
CC       snRNP complex, one of the building blocks of the spliceosome.
CC   -!- SUBUNIT: Component of the U4/U6-U5 tri-snRNP complex composed of the
CC       U4, U6 and U5 snRNAs and at least PRP3, PRP4, PRP6, PRP8, PRP18, PRP31,
CC       PRP38, SNU13, SNU23, SNU66, SNU114, SPP381, SMB1, SMD1, SMD2, SMD3,
CC       SMX2, SMX3, LSM2, LSM3, LSM4, LSM5, LSM6, LSM7, LSM8, BRR2 and DIB1.
CC       {ECO:0000269|PubMed:10377396, ECO:0000269|PubMed:10449419,
CC       ECO:0000269|PubMed:11804584}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14562095}.
CC   -!- MISCELLANEOUS: Present with 907 molecules/cell in log phase SD medium.
CC       {ECO:0000269|PubMed:14562106}.
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DR   EMBL; X95644; CAA64915.1; -; Genomic_DNA.
DR   EMBL; Z74146; CAA98665.1; -; Genomic_DNA.
DR   EMBL; BK006938; DAA11762.1; -; Genomic_DNA.
DR   PIR; S67640; S67640.
DR   RefSeq; NP_010185.1; NM_001180157.1.
DR   PDB; 5NRL; EM; 7.20 A; L=1-194.
DR   PDB; 5ZWO; EM; 3.90 A; W=1-194.
DR   PDBsum; 5NRL; -.
DR   PDBsum; 5ZWO; -.
DR   AlphaFoldDB; Q12368; -.
DR   SMR; Q12368; -.
DR   BioGRID; 31964; 224.
DR   ComplexPortal; CPX-25; U4/U6.U5 tri-small nuclear ribonucleoprotein complex.
DR   DIP; DIP-1647N; -.
DR   IntAct; Q12368; 14.
DR   MINT; Q12368; -.
DR   STRING; 4932.YDL098C; -.
DR   MaxQB; Q12368; -.
DR   PaxDb; Q12368; -.
DR   PRIDE; Q12368; -.
DR   EnsemblFungi; YDL098C_mRNA; YDL098C; YDL098C.
DR   GeneID; 851460; -.
DR   KEGG; sce:YDL098C; -.
DR   SGD; S000002256; SNU23.
DR   VEuPathDB; FungiDB:YDL098C; -.
DR   eggNOG; KOG4727; Eukaryota.
DR   HOGENOM; CLU_067237_2_1_1; -.
DR   InParanoid; Q12368; -.
DR   OMA; HKIHQIK; -.
DR   BioCyc; YEAST:G3O-29501-MON; -.
DR   PRO; PR:Q12368; -.
DR   Proteomes; UP000002311; Chromosome IV.
DR   RNAct; Q12368; protein.
DR   GO; GO:0005634; C:nucleus; IC:ComplexPortal.
DR   GO; GO:0005681; C:spliceosomal complex; IC:ComplexPortal.
DR   GO; GO:0046540; C:U4/U6 x U5 tri-snRNP complex; IDA:SGD.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; IMP:SGD.
DR   InterPro; IPR040107; Snu23.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   PANTHER; PTHR45986; PTHR45986; 1.
DR   SUPFAM; SSF57667; SSF57667; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Metal-binding; mRNA processing; mRNA splicing; Nucleus;
KW   Reference proteome; Repeat; Ribonucleoprotein; Spliceosome; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..194
FT                   /note="23 kDa U4/U6.U5 small nuclear ribonucleoprotein
FT                   component"
FT                   /id="PRO_0000232633"
FT   ZN_FING         80..104
FT                   /note="C2H2-type"
SQ   SEQUENCE   194 AA;  22679 MW;  4F1C0288149B91FB CRC64;
     MSNFGRRTWD REEYAEQARS GYDDRSLKAT LTPIELQALK SKYTNYDHLI KGSLKDLNKR
     KLTANTESLS SFKRGKKFGF YCDICNLTFK DTLQYIDHLN HKVHAIKFEN LFDEPLIIDI
     RDNDDVPQEE FELCYHNLIK DFVEVRSMET QSKRKRLLDT DVEKAKKVAT KPSIESESKV
     SQMMGFSNFA TSKK