ID   SNU71_KLULA             Reviewed;         568 AA.
AC   Q6CST6;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=U1 small nuclear ribonucleoprotein component SNU71;
GN   Name=SNU71; OrderedLocusNames=KLLA0C18007g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Component of the U1 snRNP particle, which recognizes and
CC       binds the 5'-splice site of pre-mRNA. Together with other non-snRNP
CC       factors, U1 snRNP forms the spliceosomal commitment complex, that
CC       targets pre-mRNA to the splicing pathway (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Component of the U1 snRNP particle, a subcomplex of the
CC       spliceosome. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SNU71 family. {ECO:0000305}.
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DR   EMBL; CR382123; CAH01854.1; -; Genomic_DNA.
DR   RefSeq; XP_453003.1; XM_453003.1.
DR   AlphaFoldDB; Q6CST6; -.
DR   SMR; Q6CST6; -.
DR   STRING; 28985.XP_453003.1; -.
DR   PRIDE; Q6CST6; -.
DR   EnsemblFungi; CAH01854; CAH01854; KLLA0_C18007g.
DR   GeneID; 2892608; -.
DR   KEGG; kla:KLLA0_C18007g; -.
DR   eggNOG; KOG2253; Eukaryota.
DR   HOGENOM; CLU_031562_0_0_1; -.
DR   InParanoid; Q6CST6; -.
DR   OMA; YDHHRSF; -.
DR   Proteomes; UP000000598; Chromosome C.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005685; C:U1 snRNP; IEA:EnsemblFungi.
DR   GO; GO:0071004; C:U2-type prespliceosome; IEA:EnsemblFungi.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; IEA:EnsemblFungi.
DR   InterPro; IPR002483; PWI_dom.
DR   SMART; SM00311; PWI; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Cytoplasm; mRNA processing; mRNA splicing; Nucleus;
KW   Reference proteome; Ribonucleoprotein; RNA-binding; Spliceosome.
FT   CHAIN           1..568
FT                   /note="U1 small nuclear ribonucleoprotein component SNU71"
FT                   /id="PRO_0000333458"
FT   REGION          43..71
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          299..335
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          407..464
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          260..359
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        45..71
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        316..334
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        407..442
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   568 AA;  64928 MW;  CF8AFA7057B681BC CRC64;
     MDTVLFVSPT LYCCGDTKNW QSQVPKPGYV PILKSDIPKF EQSLKQANSH RDHDKGNSVA
     SKTNETDNSD EFKTSTSRYV DLKSFLPISL EQQLHTVCLA HFPLGLGSKG IDKVMDRLDN
     LIRKKLQVED NETKFIKQWS YVDCVNTLTV YISFQESIVE EYGKAIQLLE KLFDNGSDGI
     GLHMDENTRR FVCDLTEGSP AKELDETAKD EFSALITMLR SEPGSISQEK GLAGNSAVEY
     NVDISTLSDL PSSSLDQLCK DIVEFRTRVI TLEKEKRNKE LAEEEKRRKQ NLKHIFDRIK
     VTNGGSEKGS APEAESDSED SDDEVEGYDD EDADDYEAEK KRVQAERDAQ EAQYESMVHS
     FQDSLLVQYS SLRQEYQRLQ NYETHLQKNK GPMLKELLHL AMDPYHDHHR PYKESESKAD
     EEDRKRESEE VPKKKATETE PETELELELE PETETETKLV SDADATTAAP KIKLALKKSI
     GKTKNEIEEE ETPETDAFQQ KLNLLRESGV VEELVKEYLG VYEPDLVSYI FENIEEHQSK
     QALETELTET FDEDSPVLVS RIWEAMEQ