SNURF_HUMAN
ID SNURF_HUMAN Reviewed; 71 AA.
AC Q9Y675; A6NCW2;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=SNRPN upstream reading frame protein;
GN Name=SNURF;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=10318933; DOI=10.1073/pnas.96.10.5616;
RA Gray T.A., Saitoh S., Nicholls R.D.;
RT "An imprinted, mammalian bicistronic transcript encodes two independent
RT proteins.";
RL Proc. Natl. Acad. Sci. U.S.A. 96:5616-5621(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16572171; DOI=10.1038/nature04601;
RA Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J.,
RA Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E.,
RA Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B.,
RA Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R.,
RA O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B.,
RA Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S.,
RA Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.;
RT "Analysis of the DNA sequence and duplication history of human chromosome
RT 15.";
RL Nature 440:671-675(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10318933}.
CC -!- TISSUE SPECIFICITY: Expressed in heart, skeletal muscle and
CC lymphoblasts (at protein level). Expressed in brain, pancreas, heart,
CC liver, lung, kidney and skeletal muscle. {ECO:0000269|PubMed:10318933}.
CC -!- MISCELLANEOUS: Encoded on a bicistronic transcript that code for two
CC proteins, SNRPN and SNURF. In addition to the primary 1.6-kb
CC bicistronic SNURF-SNRPN transcript, SNURF-only transcript is also
CC detected.
CC -!- SIMILARITY: Belongs to the SNURF family. {ECO:0000305}.
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DR EMBL; AF101044; AAD31391.1; -; mRNA.
DR EMBL; AC124312; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471151; EAW57625.1; -; Genomic_DNA.
DR CCDS; CCDS10016.1; -.
DR RefSeq; NP_005669.2; NM_005678.4.
DR RefSeq; NP_073715.1; NM_022804.2.
DR AlphaFoldDB; Q9Y675; -.
DR BioGRID; 114440; 6.
DR IntAct; Q9Y675; 10.
DR MINT; Q9Y675; -.
DR STRING; 9606.ENSP00000463201; -.
DR iPTMnet; Q9Y675; -.
DR PhosphoSitePlus; Q9Y675; -.
DR BioMuta; SNURF; -.
DR DMDM; 74721518; -.
DR EPD; Q9Y675; -.
DR MassIVE; Q9Y675; -.
DR PaxDb; Q9Y675; -.
DR PeptideAtlas; Q9Y675; -.
DR PRIDE; Q9Y675; -.
DR ProteomicsDB; 86613; -.
DR Antibodypedia; 70474; 20 antibodies from 9 providers.
DR DNASU; 8926; -.
DR Ensembl; ENST00000338327.4; ENSP00000342152.4; ENSG00000273173.5.
DR Ensembl; ENST00000577949.5; ENSP00000463201.1; ENSG00000273173.5.
DR Ensembl; ENST00000580062.5; ENSP00000463396.1; ENSG00000273173.5.
DR GeneID; 8926; -.
DR KEGG; hsa:8926; -.
DR MANE-Select; ENST00000577949.6; ENSP00000463201.1; NM_001394334.1; NP_001381263.1.
DR UCSC; uc001ywu.4; human.
DR CTD; 8926; -.
DR DisGeNET; 8926; -.
DR GeneCards; SNURF; -.
DR HGNC; HGNC:11171; SNURF.
DR HPA; ENSG00000273173; Tissue enhanced (skeletal).
DR neXtProt; NX_Q9Y675; -.
DR OpenTargets; ENSG00000273173; -.
DR PharmGKB; PA36010; -.
DR VEuPathDB; HostDB:ENSG00000273173; -.
DR eggNOG; ENOG502T5G1; Eukaryota.
DR GeneTree; ENSGT00390000009320; -.
DR HOGENOM; CLU_165583_0_0_1; -.
DR InParanoid; Q9Y675; -.
DR OMA; QVKHRIA; -.
DR OrthoDB; 1630470at2759; -.
DR PhylomeDB; Q9Y675; -.
DR TreeFam; TF338383; -.
DR PathwayCommons; Q9Y675; -.
DR SignaLink; Q9Y675; -.
DR BioGRID-ORCS; 8926; 5 hits in 1049 CRISPR screens.
DR GeneWiki; SNRPN_upstream_reading_frame_protein; -.
DR GenomeRNAi; 8926; -.
DR Pharos; Q9Y675; Tdark.
DR PRO; PR:Q9Y675; -.
DR Proteomes; UP000005640; Chromosome 15.
DR RNAct; Q9Y675; protein.
DR Bgee; ENSG00000273173; Expressed in cortical plate and 105 other tissues.
DR ExpressionAtlas; Q9Y675; baseline and differential.
DR Genevisible; Q9Y675; HS.
DR GO; GO:0016607; C:nuclear speck; IDA:HPA.
DR GO; GO:0005634; C:nucleus; NAS:UniProtKB.
DR GO; GO:0051117; F:ATPase binding; IEA:Ensembl.
DR InterPro; IPR009847; SNURF.
DR PANTHER; PTHR14508; PTHR14508; 1.
DR Pfam; PF07192; SNURF; 1.
PE 1: Evidence at protein level;
KW Nucleus; Reference proteome.
FT CHAIN 1..71
FT /note="SNRPN upstream reading frame protein"
FT /id="PRO_0000312993"
SQ SEQUENCE 71 AA; 8412 MW; 71FC8B9F247302C9 CRC64;
MERARDRLHL RRTTEQHVPE VEVQVKRRRT ASLSNQECQL YPRRSQQQQV PVVDFQAELR
QAFLAETPRG G
